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Abdel-Wahab, Yasser Dr

Senior Lecturer

Academic and Professional Qualifications

1985: MB, BCh Medicine, Cairo University, Egypt.

1993: DPhil Diabetes, University of Ulster, Coleraine.

Career History

2004 present: Senior Research Fellow, University of Ulster, Coleraine.

2002 - 2004: Research Fellow, University of Ulster, Coleraine.

1995 - 2002: Research Officer, University of Ulster, Coleraine.

1993 - 1995: Research Fellow, Creighton University School of Medicine, Omaha, USA.

1990 - 1993: PhD studies, University of Ulster, Coleraine.

1989 - 1990: Clinical attachment, Cuckfield Hospital, West Sussex.

1987 - 1989: Senior House Officer, Ain Shams University Cairo, Egypt.

Teaching & Learning Activities

Human Anatomy; Diabetes and Endocrinology.

School of Biomedical Sciences University of Ulster Coleraine campus Cromore Road Coleraine Co. Londonderry BT52 1SA

Tel :+44 (0)28 7032 4354 Fax:+44 (0)28 7032 4965 Email: y.abdel-wahab@ulster.ac.uk Brief profile

MB. BCh. (1985), Faculty of Medicine, Cairo University, Egypt and PhD (1993) from University of Ulster, Coleraine. Postdoctoral Research Fellow at Creighton University, School of Medicine, USA (1994-95), Postdoctoral Researcher at the University of Ulster at Coleraine (1995-2007) before taking up current appointment as Senior Lecturer in Biomedical Sciences at the University of Ulster in 2007. Dr Abdel-Wahab has over 60 peer-reviewed publications, invited speaker at many national and international conferences and is a Patent holder. Research interests

- Discovery, targets and action of antidiabetic drugs from natural resources
- Antidiabetic actions of structurally modified peptides
- Glycation of pancreatic islet peptides and proteins
- Stem cell and gene therapy in diabetes Teaching interests

Human Anatomy and Physiology, Diabetes and Natural Antidiabetic drug discovery.

Abdel-Wahab, Yasser Dr

space

Dr Yasser Abdel-Wahab
Reader
Biomedical Sciences Research Institute

space

Room Y125
School of Biomedical Sciences
University of Ulster
Coleraine campus
Cromore Road
Coleraine
Co. Londonderry
BT52 1SA

phone: +44 28 70124354
Email: y.abdel-wahab@ulster.ac.uk

Abdel-Wahab, Yasser Dr - Publications

Number of items: 94.

Moran, BM, Abdel-Wahab, Yasser, Flatt, Peter and Mckillop, Aine (2014) Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreatic β-cells.. Diabetes Obesity and Metabolism, 16 (11). pp. 1128-1139.

Mckillop, Aine, Ng, MT, Abdel-Wahab, Yasser and Flatt, Peter (2014) Evidence for inhibitory autocrine effects of proinsulin C-peptide on pancreatic β-cell function and insulin secretion.. Diabetes Obesity and Metabolsim, 16 (10). pp. 937-946.

Moran, BM, Abdel-Wahab, Yasser, Flatt, Peter and Mckillop, Aine (2014) Activation of GPR119 by fatty acid agonists augments insulin release from clonal β-cells and isolated pancreatic islets and improves glucose tolerance in mice. Biological Chemistry, 395 (4). pp. 453-464.

Srinivasan , D, Ojo, Opeolu, Abdel-Wahab, Yasser, Flatt, Peter, Guilhaudis , L and Conlon, JM (2014) Insulin-releasing and cytotoxic properties of the frog skin peptide, tigerinin-1R: a structure-activity study. Peptides, 55. pp. 23-31.

Mckillop, Aine, Moran, BM, Abdel-Wahab, Yasser and Flatt, Peter (2013) Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice.. British Journal of Pharmacology, 170 (5). pp. 978-990.

Ojo, OO, Abdel-Wahab, Yasser, Flatt, Peter and Conlon, JM (2013) Insulinotropic Actions of the Frog Skin Host-Defense Peptide Alyteserin-2a: A Structure-Activity Study. Chemical Biology & Drug Design , 82 (2). pp. 196-204.

Srinivasan , D, Mechkarska , M, Abdel-Wahab, Yasser, Flatt, Peter and Conlon, JM (2013) Caerulein precursor fragment (CPF) peptides from the skin secretions of Xenopus laevis and Silurana epitropicalis are potent insulin-releasing agents.. Biochimie, 95 (2). pp. 429-435.

Ojo, OO, Conlon, JM, Flatt, Peter and Abdel-Wahab, Yasser (2013) Frog skin peptides (tigerinin-1R, magainin-AM1, -AM2, CPF-AM1, and PGla-AM1) stimulate secretion of glucagon-like peptide 1 (GLP-1) by GLUTag cells.. Biochemical and Biophysical Research Communications, 431. pp. 14-18.

Ojo, OO, Flatt, Peter, Abdel-Wahab, Yasser and Conlon, JM (2013) Insulin-Releasing Peptides. In: Handbook of Biologically Active Peptides (2nd Edition). Elsevier, pp. 364-370. ISBN 978-0-12-385095-9

Hannan, J. M. A., Ali, Liaquat, Khaleque, Junaida, Akhter, Masfida, Flatt, Peter and Abdel-Wahab, Yasser (2012) Antihyperglycaemic activity of Asparagus racemosus roots is partly mediated by inhibition of carbohydrate digestion and absorption, and enhancement of cellular insulin action. BRITISH JOURNAL OF NUTRITION, 107 (9). pp. 1316-1323.

Ojo, O. O., Abdel-Wahab, Yasser, Flatt, Peter, Mechkarska, M. and Conlon, J. M. (2011) Tigerinin-1R: a potent, non-toxic insulin-releasing peptide isolated from the skin of the Asian frog, Hoplobatrachus rugulosus. DIABETES OBESITY and METABOLISM, 13 (12). pp. 1114-1122.

Zahid, Osama K., Mechkarska, Milena, Ojo, Opeolu O., Abdel-Wahab, Yasser, Flatt, Peter, Meetani, Mohammed A. and Conlon, J. Michael (2011) Caerulein-and xenopsin-related peptides with insulin-releasing activities from skin secretions of the clawed frogs, Xenopus borealis and Xenopus amieti (Pipidae). GENERAL AND COMPARATIVE ENDOCRINOLOGY, 172 (2). pp. 314-320.

Mechkarska, Milena, Ojo, Opeolu O., Meetani, Mohammed A., Coquet, Laurent, Jouenne, Thierry, Abdel-Wahab, Yasser, Flatt, Peter, King, Jay D. and Conlon, J. Michael (2011) Peptidomic analysis of skin secretions from the bullfrog Lithobates catesbeianus (Ranidae) identifies multiple peptides with potent insulin-releasing activity. PEPTIDES, 32 (2). pp. 203-208.

Mckillop, Aine, Ng, MT, Flatt, Peter and Abdel-Wahab, Yasser (2011) Autocrine inhibitory effects of proinsulin C-peptide and insulin on insulin secretion and pancreatic beta cell function . Diabetologia, 54. pp. S258.

Hunter, Kerry, O'Harte, FPM, Abdel-Wahab, YHA and Flatt, PR (2010) Evaluation of the inhibitory action of islet amyloid polypeptide on insulin secretion from clonal rat pancreatic beta-cells. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 44.

Abdel-Wahab, Yasser, Flatt, Peter, Patterson, S. and Conlon, J. M. (2010) Insulin-releasing properties of the frog skin peptide B2RP (brevinin-2 related peptide) and its analogues both in vitro and in vivo. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 51.

Ojo, O. O., Flatt, Peter, Conlon, M. J. and Abdel-Wahab, Yasser (2010) Isolation and structural characterization of novel insulinotropic peptides from skin secretions of Xenopus amieti. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 36-37.

McKillop, Aine, Ng, MT, Flatt, Peter and Abdel-Wahab, Yasser (2010) Involvement of proinsulin C-peptide in the regulation of pancreatic beta cell function and glucose homeostasis. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 43.

Kasabri, Violet, Flatt, Peter and Abdel-Wahab, Yasser (2010) Emblica officinalis stimulates the secretion and action of insulin and inhibits starch digestion and protein glycation. ENDOCRINE JOURNAL, 57 (Suppl. 2). pp. S367.

Kasabri, V, Flatt, Peter and Abdel-Wahab, Yasser (2010) Terminalia bellirica stimulates the secretion and action of insulin and inhibits starch digestion and protein glycation in vitro.. British Journal of Nutrition , 103 (2). pp. 212-217.

Abdel-Wahab, Yasser, Patterson, Steven, Flatt, Peter and Conlon, M (2010) Brevinin-2-related peptide and its [D4K] analogue stimulate insulin release in vitro and improve glucose tolerance in mice fed a high fat diet.. Hormone and Metabolic Research, 42(9). pp. 652-656.

Mckillop, Aine, Ng, MT, Flatt, Peter and Abdel-Wahab, Yasser (2010) Regulatory role for proinsulin C-peptide in pancreatic beta cell function and glucose homeostasis. . Irish Journal of Medical Science, 179. pp. 83.

Mckillop, Aine, Ng, MT, Flatt, Peter and Abdel-Wahab, Yasser (2009) Evidence for inhibitory autocrine effects of proinsulin C-peptide on pancreatic beta cell function and insulin secretion . DIABETOLOGIA , 52. pp. S167-S167.

Mckillop, Aine, Ng, MT, Flatt, Peter and Abdel-Wahab, Yasser (2009) Evidence for inhibitory autocrine effects of proinsulin C-peptide on pancreatic beta cell function and insulin secretion. DIABETOLOGIA, 52 (Suppl. 1). pp. 406.

Conlon, J. Michael, Abdel-Wahab, Yasser, Flatt, Peter, Leprince, Jerome, Vaudry, Hubert, Jouenne, Thierry and Condamine, Eric (2009) A glycine-leucine-rich peptide structurally related to the plasticins from skin secretions of the frog Leptodactylus laticeps (Leptodactylidae). PEPTIDES, 30 (5). pp. 888-892.

Ng, MT, Abdel-Wahab, Yasser, Flatt, Peter and Mckillop, Aine (2009) Autocrine effects of C-peptide on pancreatic beta cell function and insulin secretion in BRIN-BD11 cells and isolated islets . Irish Journal of Medical Science, 178. pp. S391.

Abdel-Wahab, Yasser, Power, Gavin J., Flatt, Peter, Woodhams, Douglas C., Rollins-Smith, Louise A. and Conlon, J. Michael (2008) A peptide of the phylloseptin family from the skin of the frog Hylomantis lemur (Phyllomedusinae) with potent in vitro and in vivo insulin-releasing activity. PEPTIDES, 29 (12). pp. 2136-2143.

Conlon, J. Michael, Power, Gavin J., Abdel-Wahab, Yasser, Flatt, Peter, Jiansheng, Hu, Coquet, Laurent, Leprince, Jerome, Jouenne, Thierry and Vaudry, Hubert (2008) A potent, non-toxic insulin-releasing peptide isolated from an extract of the skin of the Asian frog, Hylarana guntheri (Anura:Ranidae). REGULATORY PEPTIDES, 151 (1-3). pp. 153-159.

Abdel-Wahab, Yasser, Power, Gavin J., Ng, Ming T., Flatt, Peter and Conlon, J. Michael (2008) Insulin-releasing properties of the frog skin peptide pseudin-2 and its [Lys(18)]-substituted analogue. BIOLOGICAL CHEMISTRY, 389 (2). pp. 143-148.

Abdel-Wahab, Yasser, Clarke, G. C. and Flatt, Peter (2007) Acacia catechu aqueous bark extract stimulates insulin secretion and insulin action and inhibits starch digestion. DIABETOLOGIA, 50 (Suppl. 1). pp. 0915.

Hannan, J. M. A., Ali, L., Rokeya, B., Khaleque, J., Akhter, M., Flatt, Peter and Abdel-Wahab, Yasser (2007) Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action. BRITISH JOURNAL OF NUTRITION, 97 (3). pp. 514-521.

Abdel-Wahab, Yasser, Mathews, J. N. and Flatt, Peter (2007) Momordica charantia (karela) aqueous seed extract stimulates insulin secretion and insulin action in vitro. DIABETIC MEDICINE, 24 (Suppl. 1). pp. 33.

Hannan, J. M. A., Ali, Lamin Marenah Liaquat, Rokeya, Begurn, Flatt, Peter and Abdel-Wahab, Yasser (2007) Insulin secretory actions of extracts of Asparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic beta-cells. JOURNAL OF ENDOCRINOLOGY, 192 (1). pp. 159-168.

Abdel-Wahab, Yasser, Marenah, Lamin, Flatt, Peter and Conlon, J. Michael (2007) Insulin releasing properties of the temporin family of antimicrobial peptides. PROTEIN AND PEPTIDE LETTERS, 14 (7). pp. 702-707.

Doherty, Margaret, Patterson, Steven, Abdel-Wahab, Yasser and Mckillop, Aine (2007) Characterisation and detection of the insulinotropic hormones, GIP and GLP-1 in type 2 diabetes.. Irish Journal of Medical Science, 171. pp. 37.

Marenah, Lamin, McCluskey, Janie, Abdel-Wahab, Yasser, O'Harte, Finbarr, McClenaghan, Neville and Flatt, Peter (2006) A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL(16)), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones. BIOLOGICAL CHEMISTRY, 387 (7). pp. 941-947.

Hannan, J. M. A., Ali, L., Khaleque, J., Akhter, M., Flatt, Peter and Abdel-Wahab, Yasser (2006) Aqueous extracts of husks of Plantago ovata reduce hyperglycaemia in type 1 and type 2 diabetes by inhibition of intestinal glucose absorption. BRITISH JOURNAL OF NUTRITION, 96 (1). pp. 131-137.

Hannan, JMA, Marenah, L, Ali, L, Rokeya, B, Flatt, Peter and Abdel-Wahab, Yasser (2006) Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic beta-cells. JOURNAL OF ENDOCRINOLOGY, 189 (1). pp. 127-136.

Mathews, JN, Flatt, Peter and Abdel-Wahab, Yasser (2006) Asparagus adscendens (Shweta musali) stimulates insulin secretion, insulin action and inhibits starch digestion. BRITISH JOURNAL OF NUTRITION, 95 (3). pp. 576-581.

Marenah, L, Flatt, Peter, Orr, DF, Shaw, C and Abdel-Wahab, Yasser (2006) Skin secretions of Rana saharica frogs reveal antimicrobial peptides esculentins-1 and-1B and brevinins-1E and-2EC with novel insulin releasing activity. JOURNAL OF ENDOCRINOLOGY, 188 (1). pp. 1-9.

Marenah, L, Flatt, Peter, Orr, DF, Shaw, C and Abdel-Wahab, Yasser (2005) Isolation and structural characterization of novel Rugosin A-like insulinotropic peptide from the skin secretions of Rana saharica frog. PEPTIDES, 26 (11). pp. 2117-2123.

Marenah, L, Flatt, Peter, Orr, DF, Shaw, C and Abdel-Wahab, Yasser (2005) Characterization of naturally occurring peptides in the skin secretion of Rana pipiens frog reveal pipinin-1 as the novel insulin-releasing agent. JOURNAL OF PEPTIDE RESEARCH, 66 (4). pp. 204-210.

Abdel-Wahab, Yasser, Marenah, L, Orr, DF, Shaw, C and Flatt, Peter (2005) Isolation and structural characterisation of a novel 13-amino acid insulin-releasing peptide from the skin secretion of Agalychnis calcarifer. BIOLOGICAL CHEMISTRY, 386 (6). pp. 581-587.

Hannan, JMA, Abdel-Wahab, Yasser, Marenah, L, Khaleque, J, Akhter, M, Ali, L and Flatt, Peter (2005) Mechanism of insulin secretory effects of traditional antidiabetic plant extract PE027. DIABETOLOGIA, 48 (Suppl. 1). pp. 762.

Marenah, L, McClean, Stephen, Flatt, Peter, Orr, DF, Shaw, C and Abdel-Wahab, Yasser (2004) Novel insulin-releasing peptides in the skin of Phyllomedusa trinitatis frog include 28 amino acid peptide from dermaseptin BIV precursor. PANCREAS, 29 (2). pp. 110-115.

Marenah, L, Shaw, C, Orr, DF, McClean, Stephen, Flatt, Peter and Abdel-Wahab, Yasser (2004) Isolation and characterisation of an unexpected class of insulinotropic peptides in the skin of the frog Agalychnis litodryas. REGULATORY PEPTIDES, 120 (1-3). pp. 33-38.

Abdel-Wahab, Yasser, Marenah, L, Orr, DF, Shaw, C and Flatt, Peter (2004) Isolation and structural characterisation of a novel 13 amino acid insulin-releasing peptide from the skin secretion of Agalychnis calcarifer. DIABETOLOGIA, 47 (Suppl. 1). pp. 12.

Miguel, JC, Patterson, Steven, Abdel-Wahab, Yasser, Mathias, PCF and Flatt, Peter (2004) Time-correlation between membrane depolarization and intracellular calcium in insulin secreting BRIN-BD11 cells: studies using FLIPR. CELL CALCIUM, 36 (1). pp. 43-50.

Marenah, L., Flatt, Peter, Orr, D. F., McClean, Stephen, Shaw, C. and Abdel-Wahab, Yasser (2004) Brevinin-1 and multiple insulin-releasing peptides in the skin of the frog Rana palustris. Journal of Endocrinology, 181 (2). pp. 347-354.

Marenah, L, Flatt, Peter, Orr, DF, McClean, Stephen, Shaw, C and Abdel-Wahab, Yasser (2004) Skin secretion of the toad Bombina variegata contains multiple insulin-releasing peptides including bombesin and entirely novel insulinotropic structures. BIOLOGICAL CHEMISTRY, 385 (3-4). pp. 315-321.

Gallagher, Alison, Flatt, Peter, Duffy, G and Abdel-Wahab, Yasser (2003) The effects of traditional antidiabetic plants on in vitro glucose diffusion. NUTRITION RESEARCH, 23 (3). pp. 413-424.

Miguel, JC, Abdel-Wahab, Yasser, Green, BD, Mathias, PCF and Flatt, Peter (2003) Cooperative enhancement of insulinotropic action of GLP-1 by acetylcholine uncovers paradoxical inhibitory effect of beta cell muscarinic receptor activation on adenylate cyclase activity. BIOCHEMICAL PHARMACOLOGY, 65 (2). pp. 283-292.

McKillop, Aine, Abdel-Wahab, Yasser, Mooney, MH, O'Harte, Finbarr and Flatt, Peter (2002) Secretion of glycated insulin from pancreatic beta-cells in diabetes represents a novel aspect of beta-cell dysfunction and glucose toxicity. DIABETES AND METABOLISM, 28 (6, Part 2). pp. S61-S69.

Abdel-Wahab, Yasser, Marenah, L, Shaw, C and Flatt, Peter (2002) Isolation and structural characterisation of novel insulinotropic peptides from the skin secretion of Rana Pipiens. DIABETOLOGIA, 45 (Suppl. 2). pp. 549.

Abdel-Wahab, Yasser, O'Harte, Finbarr, Mooney, MH, Barnett, CR and Flatt, Peter (2002) Vitamin C supplementation decreases insulin glycation and improves glucose homeostasis in obese hyperglycemic (ob/ob) mice. METABOLISM-CLINICAL AND EXPERIMENTAL, 51 (4). pp. 514-517.

Conroy, SJ, Green, I, Dixon, G, Byrne, PM, Nolan, J, Abdel-Wahab, Yasser, McClenaghan, Neville, Flatt, Peter and Newsholme, P (2002) Evidence for a sustained increase in clonal beta-cell basal intracellular Ca2+ levels after incubation in the presence of newly diagnosed type-1 diabetic patient sera. Possible role in serum-induced inhibition of insulin secretion. JOURNAL OF ENDOCRINOLOGY, 173 (1). pp. 53-62.

Mooney, MH, Abdel-Wahab, Yasser, McKillop, Aine, O'Harte, Finbarr and Flatt, Peter (2002) Evaluation of glycated glucagon-like peptide-1(7-36)amide in intestinal tissue of normal and diabetic animal models. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1569 (1-3). pp. 75-80.

Miguel, JC, Abdel-Wahab, Yasser, Mathias, PCF and Flatt, Peter (2002) Muscarinic receptor subtypes mediate stimulatory and paradoxical inhibitory effects on an insulin-secreting beta cell line. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1569 (1-3). pp. 45-50.

Mooney, MH, Abdel-Wahab, Yasser, Morgan, LM, O'Harte, Finbarr and Flatt, Peter (2001) Detection of glycated gastric inhibitory polypeptide within the intestines of diabetic obese (ob/ob) mice. ENDOCRINE, 16 (3). pp. 167-171.

Mooney, MH, Gault, Victor, Abdel-Wahab, Yasser, Flatt, Peter and O'Harte, Finbarr (2001) Identification of Tyr(1)-glucitol GIP in intestines of diabetic mice with enhanced insulin-releasing activity. DIABETOLOGIA, 44 (Suppl. 1). pp. 1223.

Abdel-Wahab, Yasser, Marenah, L, Shaw, C and Flatt, Peter (2001) Isolation and structural characterisation of insulinotropic peptides from Bombina variegata. DIABETOLOGIA, 44 (Suppl. 1). pp. 516.

Murphy, LO, Abdel-Wahab, YHA, Wang, QJ, Knezetic, JA, Permnert, J, Larsson, J, Hollingsworth, AM and Adrian, TE (2001) Receptors and ligands for autocrine growth pathways are up-regulated when pancreatic cancer cells are adapted to serum-free culture.. Pancreas, 22 (3). pp. 293-298.

O'Harte, Finbarr, Boyd, AC, McKillop, Aine, Abdel-Wahab, Yasser, McNulty, Helene, Barnett, CR, Conlon, JM, Hojrup, P and Flatt, Peter (2000) Structure, antihyperglycemic activity and cellular actions of a novel diglycated human insulin. PEPTIDES, 21 (10). pp. 1519-1526.

Boyd, AC, Abdel-Wahab, Yasser, McKillop, Aine, McNulty, Helene, Barnett, CR, O'Harte, Finbarr and Flatt, Peter (2000) Impaired ability of glycated insulin to regulate plasma glucose and stimulate glucose transport and metabolism in mouse abdominal muscle. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1523 (1). pp. 128-134.

Ahmad, M, Abdel-Wahab, Yasser, Tate, R, Flatt, Peter, Pyne, NJ and Furman, BL (2000) Effect of type-selective inhibitors on cyclic nucleotide phosphodiesterase activity and insulin secretion in the clonal insulin secreting cell Line BRIN-BD11. BRITISH JOURNAL OF PHARMACOLOGY, 129 (6). pp. 1228-1234.

Conroy, SJ, Abdel-Wahab, Yasser, Caraher, EM, Byrne, PM, Murphy, E, Nolan, J, Flatt, Peter and Newsholme, P (2000) Evidence for complement-dependent and -independent inhibition of insulin secretion from clonal beta-cells incubated in the presence of sera of newly diagnosed IDDM patients. JOURNAL OF ENDOCRINOLOGY, 164 (2). pp. 139-147.

McKillop, Aine, Abdel-Wahab, Yasser and Flatt, Peter (2000) The traditional plant treatment, Sambucus nigra (elder), exhibits insulin-like and insulin-releasing actions in vitro. JOURNAL OF NUTRITION, 130 (1). pp. 15-20.

Gray, Alison, Abdel-Wahab, Yasser and Flatt, Peter (2000) Insulin-like and insulin-releasing actions of the traditional antidiabetic plant Sambucus nigra (elder).. Journal of Nutrition, 130 (1). pp. 15-20.

Abdel-Wahab, Yasser, O'Harte, Finbarr, Mooney, MH, Conlon, JM and Flatt, Peter (1999) N-terminal glycation of cholecystokinin-8 abolishes its insulinotropic action on clonal pancreatic B-cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1452 (1). pp. 60-67.

Abdel-Wahab, Yasser, Mooney, MH, O'Harte, Finbarr and Flatt, Peter (1999) N-terminal glycation of CCK-8 abolishes its insulinotropic action on clonal B-cells. DIABETOLOGIA, 42 (Suppl. 1). pp. 545.

Barnes, PD, O'Brien, RE, Abdel-Wahab, Yasser, Cosgrove, KE, Flatt, Peter and Dunne, MJ (1999) Hydrochlorothiazide: An hyperglycaemia-inducing agent and K-ATP channel agonist in human beta-cells and clonal insulin-secreting cells.. DIABETOLOGIA, 42 (Suppl. 1). pp. 482.

O'Harte, Finbarr, Abdel-Wahab, Yasser, Conlon, JM and Flatt, Peter (1998) Glycation of glucagon-like peptide-1(7-36)amide: characterization and impaired action on rat insulin secreting cells. DIABETOLOGIA, 41 (10). pp. 1187-1193.

O'Harte, Finbarr, Abdel-Wahab, Yasser, Conlon, JM and Flatt, Peter (1998) Amino terminal glycation of gastric inhibitory polypeptide enhances its insulinotropic action on clonal pancreatic B-cells. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1425 (2). pp. 319-327.

Flatt, Peter, Abdel-Wahab, Yasser, Ahmad, M, Pyne, NJ and Furman, BL (1998) Characterisation and functional role of cyclic AMP phosphodiesterases in clonal beta-cells. DIABETOLOGIA, 41 (Suppl. 1). pp. 521.

Conlon, JM, Abdel-Wahab, Yasser, O'Harte, FPM, Nielsen, PF and Whittaker, J (1998) Purification and characterization of insulin, glucagon, and two glucagon-like peptides with insulin-releasing activity from the pancreas of the toad, Bufo marinus. ENDOCRINOLOGY, 139 (8). pp. 3442-3448.

Abdel-Wahab, Yasser, Davies, EL, Bailey, CJ and Flatt, Peter (1998) Enhanced function of electrofusion-derived surrogate B-cells implanted in diabetic nude mice. DIABETOLOGIA, 41 (Suppl. 1). pp. 511.

Ahmad, M, Abdel-Wahab, Yasser, Pyne, NJ, Flatt, Peter and Furman, BL (1998) Effects of type selective inhibitors can cAMP phosphodiesterase activity and insulin secretion in the clonal beta cell BRIN BD11. BRITISH JOURNAL OF PHARMACOLOGY, 123 (Suppl. S). pp. 156P.

O'Harte, Finbarr, Abdel-Wahab, Yasser, Conlon, JM and Flatt, Peter (1998) Glycated IAPP shows a reduced inhibitory action on insulin secretion.. BIOCHEMICAL SOCIETY TRANSACTIONS, 26 (1). pp. S6.

Flatt, Peter, Abdel-Wahab, Yasser, Boyd, AC, Barnett, CR and Flatt, Peter (1997) Pancreatic B-cell dysfunction and glucose toxicity in non-insulin-dependent diabetes. PROCEEDINGS OF THE NUTRITION SOCIETY, 56 (1B). pp. 243-262.

Abdel-Wahab, Yasser, O'Harte, Finbarr, Barnett, CR and Flatt, Peter (1997) Characterization of insulin glycation in insulin-secreting cells maintained in tissue culture. JOURNAL OF ENDOCRINOLOGY, 152 (1). pp. 59-67.

O'Harte, Finbarr, Gallagher, Alison, Abdel-Wahab, Yasser and Flatt, Peter (1997) Effects of non-glycated and glycated glucagon-like peptide-1(7-36) amide on glucose metabolism in isolated mouse abdominal muscle. PEPTIDES, 18 (9). pp. 1327-1333.

O'Harte, FPM, Gray, Alison, Abdel-Wahab, Yasser and Flatt, Peter (1997) Effects of glycated and non-glycated gastric inhibitory polypeptide on glucose transport and metabolism in isolated mouse abdominal muscle.. Proceedings of the Nutrition Society, 56 (1A). pp. 42A.

Boyd, AC, O'Harte, FPM, Gray, Alison, Abdel-Wahab, Yasser, Barnett, CR and Flatt, Peter (1997) Mono- and di-glycated insulin exhibit reduced cellular glucose uptake and glucose lowering activity in mice.. Proceedings of the Nutrition Society, 56 (1A). pp. 43A.

Abdel-Wahab, Yasser, O'Harte, Finbarr, Boyd, AC, Barnett, CR and Flatt, Peter (1997) Glycation of insulin results in reduced biological activity in mice. ACTA DIABETOLOGICA, 34 (4). pp. 265-270.

Abdel-Wahab, Yasser, O'Harte, Finbarr, Ratcliff, H, McClenaghan, Neville, Barnett, CR and Flatt, Peter (1996) Glycation of insulin in the islets of Langerhans of normal and diabetic animals. DIABETES, 45 (11). pp. 1489-1496.

Abdel-Wahab, Yasser, O'Harte, Finbarr, Gallagher, Alison and Flatt, Peter (1996) Glycation of GLP-1[7-36]amide but not GIP reduces its insulinotropic action in vitro. DIABETOLOGIA, 39 (Suppl. 1). pp. 84.

McClenaghan, Neville, Barnett, CR, AhSing, E, Abdel-Wahab, Yasser, O'Harte, Finbarr, Yoon, TW, SwanstonFlatt, SK and Flatt, Peter (1996) Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion. DIABETES, 45 (8). pp. 1132-1140.

Boyd, AC, O'Harte, Finbarr, Gallagher, Alison, Abdel-Wahab, Yasser, McNulty, Helene, Barnett, CR and Flatt, Peter (1996) Reduced biological potency of mono-glycated insulin in vitro and in vivo in mice. DIABETOLOGIA, 39 (Suppl. 1). pp. 83.

O'Harte, Finbarr, Gallagher, Alison, Abdel-Wahab, Yasser and Flatt, Peter (1996) Effects of glycated and non-glycated GLP-1[7-36]amide on glucose metabolism in muscle. DIABETOLOGIA, 39 (Suppl. 1). pp. 82.

Flatt, Peter, O'Harte, Finbarr, Abdel-Wahab, Yasser, McClenaghan, Neville and Barrnett, CR (1995) GLYCATION OF INSULIN AND PROINSULIN OCCURS IN THE ISLETS OF LANGERHANS OF DIABETIC ANIMALS. DIABETOLOGIA, 38 (Suppl. 1). pp. A92.

McClenaghan, Neville, Yoon, TW, Barnett, CR, Wilson, AM, Abdel-Wahab, Yasser, Swanstonflatt, S, Ahsing, E and Flatt, Peter (1994) EFFECT OF GLUCOSE AND AMINO-ACIDS ON INSULIN-SECRETION FROM A NOVEL PANCREATIC B-CELL LINE PRODUCED BY ELECTROFUSION. BIOCHEMICAL SOCIETY TRANSACTIONS, 22 (2). pp. S237.

Abdel-Wahab, Yasser, O'Harte, Finbarr, Barnett, CR and Flatt, Peter (1994) STUDIES OF THE EFFECT OF GLYCATION OF INSULIN ON GLUCOSE-METABOLISM IN ISOLATED MOUSE DIAPHRAGM MUSCLE. BIOCHEMICAL SOCIETY TRANSACTIONS, 22 (2). pp. S238.

O'Harte, Finbarr, Boyd, AC, Abdel-Wahab, Yasser, Barnett, CR and Flatt, Peter (1994) CHARACTERIZATION OF THE GLYCATION OF HUMAN INSULIN BY REVERSED-PHASE HPLC. BIOCHEMICAL SOCIETY TRANSACTIONS, 22 (2). pp. S239.

Flatt, Peter, Yoon, TW, Barnett, CR, McClenaghan, Neville, Wilson, AM, Abdel-Wahab, Yasser, Ahsing, E and Swanstonflatt, SK (1993) PRODUCTION OF A NOVEL GLUCOSE-RESPONSIVE INSULIN-SECRETING PANCREATIC B-CELL LINE BY ELECTROFUSION. DIABETOLOGIA, 36 (Suppl. 1). pp. A31.

This list was generated on Thu Oct 23 06:52:57 2014 BST.