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Bjourson, Tony Professor

Director - Biomedical Sciences Research Institute

Academic and Professional Qualifications

  • 1996: PhD Molecular Signalling, Queen’s University of Belfast.
  • 1992: MSc Biological Sciences, University of Ulster, Coleraine.
  • 1982: HNC in Biomedical Sciences, Ulster Polytechnic College.

Career History

  • 2007 - present: Director, Biomedical Sciences Research Institute
  • 2005 - present: Professor of Genomics, University of Ulster, Coleraine.
  • 2001 - 2005: Senior Lecturer in Genomics, University of Ulster, Coleraine.
  • 1996 - 2001: Senior Scientific Officer, DARDNI/ QUB.
  • 1990 - 1996: Senior Scientific Officer, DANI Science.
  • 1986 - 1990: Higher Scientific Officer, DANI Science.
  • 1982 - 1990: Scientific Officer, DANI Science.
  • 1977 - 1982: Assistant Scientific Officer, DANI Science.

Biography Tony Bjourson was born in Strabane, Co Tyrone in Northern Ireland. He was appointed Director of the Biomedical Sciences Research Institute (BMSRI) at the University of Ulster in late 2007 and currently manages the 240 Researchers within the BMSRI. He obtained his MSc in Biological Sciences from the University of Ulster and his PhD from Queen’s University Belfast. He has over 28 years of research experience in a diverse range of molecular biological/genomic projects and he has published extensively in peer-reviewed molecular biology journals. Prior to joining Ulster in 2001, he established and managed genomic programmes for the DARDNI and Queens University Belfast and participated in the first ever international eukaryotic genome project (EU Yeast Genome sequencing program 1994-1996). In the early 1990’s he developed novel subtraction hybridisation technologies that were subsequently used for the identification of specific nucleic acid sequences in a diverse range of cell types. After joining Ulster he led the Pharmaceutical Biotechnology Research Group and subsequently established and led the Biomedical Genomics Research Group. He also managed the Core Genomics Unit within the Centre for Molecular Biosciences (CMB). He has considerable experience of managing both large research infrastructure projects, focused basic research projects, and overseeing delivery of associated objectives. Professor Bjourson currently serves as a Director on the boards of two companies; the Clinical Translation Research & Innovation Centre (C-TRIC) based in L/Derry aimed at translating biomedical research outputs from laboratory bench to patient bedside. He also serves on the Board of Directors of the Ulster venture company Innovation Ulster Ltd. His current research is focused on genomics based personalised medicine in the area of cancer and autoimmune disease and pharmacogenomic. He also is a Steering Committee member of the Northern Ireland Biobank, a Council Member of the Irish Society for Clinical genetics. He is also highly committed to economic regeneration in Ireland and the North West region in particular; he was a founding member of the North West Science & Technology Partnership (NWSTP) and the Clinical Translational Research & innovation Centre (C-TRIC).

Teaching & Learning Activities

Subject Areas: Genomics/ Bioinformatics; GM Plants; recombinant protein production.

Research Interests: Current research includes:

The isolation of biomarkers for personalised medicine relating to degenerative diseases including breast cancer (invasion and metastasis associated biomarkers).

An in vitro model of the pathway leading to breast cancer invasion has been generated and the genomic, transcriptomic (microRNA/mRNA), methylation status & proteomic signatures associated with invasion are investigated using laboratory technologies integrated with a systems biology approach

Rheumatoid arthritis (responsiveness to anti TNF alpha. -DEL Cast Studentship in colaboration with Belfast City Hospital / Musgrave Park Hospital).

Other research involves determining the potential for lateral transfer of genetic information from maternal breast milk to the neonate (Invest NI-Centre for Functional Genomics funded project).

Collaborative research on the genomics & proteomics of snake and amphibian venomics is also undertaken aimed at the isolation of new clinically relevant pharmaceutical drugs.

Bjourson, Tony Professor

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Professor Tony Bjourson
Director of the Biomedical Sciences Research Institute
Biomedical Sciences Research Institute

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Room W0095
School of Biomedical Sciences
University of Ulster
Coleraine campus
Cromore Road
Coleraine
Co. Londonderry
BT52 1SA

phone: +44 28 70124885
Email: aj.bjourson@ulster.ac.uk

Bjourson, Tony Professor - Publications

Number of items: 46.

Guo, Chun-teng, McClean, Stephen, Shaw, Chris, Rao, Ping-fan, Ye, Ming-yu and Bjourson, AJ (2013) Purification, characterization and molecular cloning of chymotrypsin inhibitor peptides from the venom of Burmese Daboia russelli siamensis. Peptides, 43. pp. 126- 132.

Guo, Chun-teng, McClean, Stephen, Shaw, Chris, Rao, Ping-fan, Ye, Ming-yu and Bjourson, AJ (2013) Trypsin and chymotrypsin inhibitor peptides from the venom of Chinese Daboia russellii siamensis. Toxicon, 63. pp. 154-164.

McGeough, Cathy and Bjourson, AJ (2012) Diagnostic, Prognostic and Theranostic Genetic Biomarkers forRheumatoid Arthritis. Journal of Clinical and Cellular Immunology, S6.

McGeough, Cathy, Berrar, Daniel, Wright, Gary, Mathews, Clare, Gilmore, Paula, Cunningham, Rodat T. and Bjourson, AJ (2012) Killer immunoglobulin-like receptor and human leukocyte antigen-C genotypes in rheumatoid arthritis primary responders and non-responders to anti-TNF-α therapy. Rheumatology International, 32 (6). pp. 1647-1653.

McGeough, Cathy and Bjourson, AJ (2012) Diagnostic, Prognostic and Theranostic Genetic Biomarkers for Rheumatoid Arthritis. Journal of Clinical & Cellular Immunology, N/A.

Drain, Stephen, Catherwood, Mark A., Bjourson, AJ, Drake, Mary B., Kettle, Paul J. and Alexander, H. Denis (2012) Neither P-gp SNP variants, P-gp expression nor functional P-gp activity predicts MDR in a preliminary study of plasma cell myeloma. Cytometry Part B: Clinical Cytometry, TBC. pp. n/a.

Drain, Stephen, Flannely, Louise, Drake, Mary B., Kettle, Paul, Orr, Nick, Bjourson, AJ, Catherwood, Mark A. and Alexander, H. Denis (2011) Multidrug resistance gene expression and ABCB1 SNPs in plasma cell myeloma. Leukemia Research, 35 (11). pp. 1457-1463.

McGeough, Cathy, Berrar, Daniel, Wright, Gary, Mathews, Clare, Gilmore, Paula, Cunningham, Rodat T. and Bjourson, AJ (2011) Killer immunoglobulin-like receptor and human leukocyte antigen-C genotypes in rheumatoid arthritis primary responders and non-responders to anti-TNF-α therapy. Rheumatology International, 32 (6). pp. 1647.

Bjourson, AJ, Berrar, Daniel and McErlean, Seona (2010) METHOD OF STRATIFYING BREAST CANCER PATIENTS BASED ON GENE EXPRESSION.Professor Anthony Bjourson (2010) METHOD OF STRATIFYING BREAST CANCER PATIENTS BASED ON GENE EXPRESSION.

Bjourson, AJ, Berrar, Daniel and McGeough, Cathy (2009) USE OF KIR GENES FOR PREDICTING RESPONSE TO THERAPY.Professor Anthony Bjourson (2009) USE OF KIR GENES FOR PREDICTING RESPONSE TO THERAPY.

Thompson, Alan Hunter, Bjourson, AJ, Orr, David Francis, Shaw, Chris and McClean, Stephen (2007) Amphibian skin secretomics: Application of parallel quadrupole time-of-flight mass spectrometry and peptide precursor cDNA cloning to rapidly characterize the skin secretory peptidome of Phyllomedusa hypochondrialis azurea: Discovery of a novel peptide family, the hyposins. JOURNAL OF PROTEOME RESEARCH, 6 (9). pp. 3604-3613.

Thompson, Alan Hunter, Bjourson, AJ, Orr, David Francis, Shaw, Chris and McClean, Stephen (2007) A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea. PEPTIDES, 28 (7). pp. 1331-1343.

Boukli, N. M., Sunderasan, E., Bartsev, A., Hochstrasser, D., Perret, X., Bjourson, AJ, Krause, A. and Broughton, W. J. (2007) Early legume responses to inoculation with Rhizobium sp NGR234. JOURNAL OF PLANT PHYSIOLOGY, 164 (6). pp. 794-806.

Zhou, J. W., Bjourson, AJ, Coulter, Danny, Chen, T. B., Shaw, C., O'Rourke, M., Hirst, D. G., Zhang, Y. N., Rao, P. F. and McClean, Stephen (2007) Bradykinin-related peptides, including a novel structural variant, (Val(1))-bradykinin, from the skin secretion of Guenther's frog, Hylarana guentheri and their molecular precursors. Peptides, 28 (4). pp. 781-789.

Zhou, Jianwu, Mcclean, Stephen, Thompson, Alan, Zhang, Yang, Shaw, Chris, Rao, Pingfan and Bjourson, AJ (2006) Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri. PEPTIDES, 27 (12). pp. 3077-3084.

Thompson, Alan Hunter, Bjourson, AJ, Shaw, Chris and McClean, Stephen (2006) Bradykinin-related peptides from Phyllomedusa hypochondrialis azurea: mass spectrometric structural characterisation and cloning of precursor cDNAs. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 20 (24). pp. 3780-3788.

Falchi, A, Scott, N, Hayes, VEA, Barnett, YA, Garstin, I, Logan, P, Morrison, PJ and Bjourson, AJ (2005) Analysis of BRCA2 point mutations and exon deletions/amplifications in breast and breast/ovarian cancer families . In: Meeting of the International-Society-for-Cellular-Oncology . Cellular Oncology. Vol 27 (2), 100-101

Chen, TB, Orr, DF, O'Rourke, M, McLynn, C, Bjourson, AJ, McClean, Stephen, Hirst, D, Rao, PF and Shaw, C (2004) Pachymedusa dacnicolor tryptophyllin-1: structural characterization, pharmacological activity and cloning of precursor cDNA. REGULATORY PEPTIDES, 117 (1). pp. 25-32.

Chen, TB, Folan, R, Kwok, HF, O'Kane, EJ, Bjourson, AJ and Shaw, C (2003) Isolation of scorpion (Androctonus amoreuxi) putative alpha neurotoxins and parallel cloning of their respective cDNAs from a single sample of venom. REGULATORY PEPTIDES, 115 (2). pp. 115-121.

Li, L, Bjourson, AJ, He, JY, Cai, GX, Rao, PF and Shaw, C (2003) Bradykinins and their cDNA from piebald odorous frog, Odorrana schmackeri, skin. PEPTIDES, 24 (6). pp. 863-872.

Chen, TB, Bjourson, AJ, McClean, Stephen, Orr, DF, O'Kane, EJ, Rao, PF and Shaw, C (2003) Cloning of maximakinin precursor cDNAs from Chinese toad, Bombina maxima, venom. PEPTIDES, 24 (6). pp. 853-861.

Chen, TB, Farragher, S, Bjourson, AJ, Orr, DF, Rao, P and Shaw, C (2003) Granular gland transcriptomes in stimulated amphibian skin secretions. BIOCHEMICAL JOURNAL, 371 (Part 1). pp. 125-130.

Chen, TB, Bjourson, AJ, Orr, DF, Kwok, H, Rao, PF, Ivanyi, C and Shaw, C (2002) Unmasking venom gland transcriptomes in reptile venoms. ANALYTICAL BIOCHEMISTRY, 311 (2). pp. 152-156.

Crockard, MA, Bjourson, AJ, Dazzo, FB and Cooper, JE (2002) A white clover nodulin gene, dd23b, encoding a cysteine cluster protein, is expressed in roots during the very early stages of interaction with Rhizobium leguminosarum biovar trifolii and after treatment with chitolipooligosaccharide Nod factors. JOURNAL OF PLANT RESEARCH, 115 (1122). pp. 439-447.

Chen, TB, Orr, DF, Bjourson, AJ, McClean, Stephen, O'Rourke, M, Hirst, DG, Rao, PF and Shaw, C (2002) Novel bradykinins and their precursor cDNAs from European yellow-bellied toad (Bombina variegata) skin. EUROPEAN JOURNAL OF BIOCHEMISTRY, 269 (18). pp. 4693-4700.

Chen, TB, Orr, DF, Bjourson, AJ, McClean, Stephen, O'Rourke, M, Hirst, DG, Rao, PF and Shaw, C (2002) Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad (Bombina orientalis). PEPTIDES, 23 (9). pp. 1547-1555.

Kimber, MJ, Fleming, CC, Bjourson, AJ, Halton, DW and Maule, AG (2002) FMRFamide-related peptides in potato cyst nematodes (vol 116, pg 199, 2001). MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 120 (2). pp. 327-328.

Crockard, MA, Bjourson, AJ, Pulvirenti, MG and Cooper, JE (2001) Temporal and spatial expression analyses of TrEhod40, TrEnod5 and a novel early nodulin in white clover roots and nodules. PLANT SCIENCE, 161 (6). pp. 1161-1170.

Kimber, MJ, Fleming, CC, Bjourson, AJ, Halton, DW and Maule, AG (2001) FMRFamide-related peptides in potato cyst nematodes. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 116 (2). pp. 199-208.

Meehan, C, Bjourson, AJ and McMullan, Geoffrey (2001) Paenibacillus azoreducens sp nov., a synthetic azo dye decolorizing bacterium from industrial wastewater. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 51 (Part 5). pp. 1681-1685.

Crockard, MA, Bjourson, AJ and Cooper, JE (1999) A new peroxidase cDNA from white clover: Its characterization and expression in root tissue challenged with homologous rhizobia, heterologous rhizobia, or Pseudomonas syringae. MOLECULAR PLANT-MICROBE INTERACTIONS, 12 (9). pp. 825-828.

Creelan, JL, Bjourson, AJ, Meehan, BM and McCullough, SJ (1999) Characterisation of strain-specific sequences from an abortifacient strain of ovine Chlamydia psittaci using subtraction hybridisation. FEMS MICROBIOLOGY LETTERS, 171 (1). pp. 17-25.

McKay, GJ, Brown, AE, Bjourson, AJ and Mercer, PC (1999) Molecular characterisation of Alternaria linicola and its detection in linseed. EUROPEAN JOURNAL OF PLANT PATHOLOGY, 105 (2). pp. 157-166.

McGrattan, PD, Wylie, ARG and Bjourson, AJ (1998) A partial cDNA sequence of the ovine insulin receptor gene: evidence for alternative splicing of an exon 11 region and for tissue-specific regulation of receptor isoform expression in sheep muscle, adipose tissue and liver. JOURNAL OF ENDOCRINOLOGY, 159 (3). pp. 381-387.

Crockard, MA, Fulton, CE, Bjourson, AJ and Brown, AE (1998) Intron polymorphism in small subunit rDNA of Nectria galligena. MICROBIOLOGY-UK, 144 (Part 8). pp. 2367-2372.

Cooper, JE, Bjourson, AJ, Streit, W and Werner, D (1998) Isolation of unique nucleic acid sequences from rhizobia by genomic subtraction: Applications in microbial ecology and symbiotic gene analysis. PLANT AND SOIL, 204 (1). pp. 47-55.

Bjourson, AJ (1997) The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. NATURE, 387 (6632, Suppl. S). pp. 81-84.

Wilson, IG, Gilmour, K, Cooper, JE, Bjourson, AJ and Harvey, J (1994) A NONISOTOPIC DNA HYBRIDIZATION ASSAY FOR THE IDENTIFICATION OF STAPHYLOCOCCUS-AUREUS ISOLATED FROM FOODS. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 22 (1). pp. 43-54.

Perret, X, Fellay, R, Bjourson, AJ, Cooper, JE, Brenner, S and Broughton, WJ (1994) SUBTRACTION HYBRIDIZATION AND SHOT-GUN SEQUENCING - A NEW APPROACH TO IDENTIFY SYMBIOTIC LOCI. NUCLEIC ACIDS RESEARCH, 22 (8). pp. 1335-1341.

Streit, W, Bjourson, AJ, Cooper, JE and Werner, D (1993) APPLICATION OF SUBTRACTION HYBRIDIZATION FOR THE DEVELOPMENT OF A RHIZOBIUM-LEGUMINOSARUM BIOVAR PHASEOLI AND RHIZOBIUM-TROPICI GROUP-SPECIFIC DNA-PROBE. FEMS MICROBIOLOGY ECOLOGY, 13 (1). pp. 59-67.

Bjourson, AJ and Cooper, JE (1992) BAND-STAB PCR - A SIMPLE TECHNIQUE FOR THE PURIFICATION OF INDIVIDUAL PCR PRODUCTS. NUCLEIC ACIDS RESEARCH, 20 (17). pp. 4675.

Bjourson, AJ, Stone, CE and Cooper, JE (1992) COMBINED SUBTRACTION HYBRIDIZATION AND POLYMERASE CHAIN-REACTION AMPLIFICATION PROCEDURE FOR ISOLATION OF STRAIN-SPECIFIC RHIZOBIUM DNA-SEQUENCES. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 58 (7). pp. 2296-2301.

Bjourson, AJ and Cooper, JE (1988) ISOLATION OF RHIZOBIUM-LOTI STRAIN-SPECIFIC DNA-SEQUENCES BY SUBTRACTION HYBRIDIZATION. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 54 (11). pp. 2852-2855.

Wood, M, Cooper, JE and Bjourson, AJ (1988) RESPONSE OF LOTUS RHIZOBIA TO ACIDITY AND ALUMINUM IN LIQUID CULTURE AND IN SOIL. PLANT AND SOIL, 107 (2). pp. 227-231.

Cooper, JE, Bjourson, AJ and Thompson, JK (1987) Identification of Lotus Rhizobia by Direct DNA Hybridization of Crushed Root-nodules. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 53 (7). pp. 1705-1707.

Cooper, JE, Wood, M and Bjourson, AJ (1985) NODULATION OF LOTUS-PEDUNCULATUS IN ACID ROOTING SOLUTION BY FAST-GROWING AND SLOW-GROWING RHIZOBIA. SOIL BIOLOGY & BIOCHEMISTRY, 17 (4). pp. 487-492.

This list was generated on Tue Sep 2 17:41:04 2014 BST.