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Flatt, Peter Professor

Professor of Biological & Biomedical Sciences

Academic and Professional Qualifications
- 1974: BSc (First Class Honours) Biology / Chemistry, Aston University
- 1977: PhD in Diabetes Research, Aston University

Career History
- 1989 - present: Professor of Biomedical Sciences, University of Ulster
- 1980 - 1984: Lecturer / Senior Lecturer, University of Surrey
- 1978 - 1979: Research Fellow, University of Uppsala

Teaching & Learning Activities
- Physiology

Research interests
- Insulin secretion
- pancreatic islet cell function and demise
- antidiabetic drugs
- gene therapy
- brain and gut peptides
- glucose homeostasis
- insulinoma and obesity

Brief profile BSc Hons and PhD from Aston University. Research Fellow at the University of Uppsala, Sweden (1978-80) before taking up an academic appointment at Surrey University in 1980 and current position as Professor of Biomedical Sciences in 1989. Professor Flatt is Head of the Diabetes Research Group, having served as Director of Biomedical Sciences Research Centre (1992-94) and Head of the School of Biomedical Sciences (1994-97).

Professor Flatt is author of over 400 full scientific peer-reviewed papers on various aspects of diabetes and editor of 4 major diabetes research texts including New Antidiabetic Drugs (Smith-Gordon, 1990) and Nutrient Regulation of Insulin Secretion (Portland Press, 1992).

He is founding Chairman (1991-) of the Islet Study Group of the European Association for the Study of Diabetes (EASD), Member of the EASD Council (1997-01), Scientific Secretary and Committee Member of Diabetes UK (1991-97; 2001-04) and member of the Grants Review Board of the Juvenile Diabetes Federation International (1996-99).

Recipient: Mary Jane Kugal Award (1999) of Juvenile Diabetes Federation International, Biochemical Society Medal (2005), elected to membership of Royal Irish Academy (2006), University of Ulster Distinguished Senior Research Fellowship (2006) and Diabetes UK Dorothy Hodgkin Award Lecturer (2008). Patent holder, academic co-founder and Chief Scientific Officer/Director of Diabetica Ltd.

Flatt, Peter Professor

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Professor Peter Flatt
Professor of Biological & Biomedical Sciences
Biomedical Sciences Research Institute

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Room Y128
School of Biomedical Sciences
University of Ulster
Coleraine campus
Cromore Road
Coleraine
Co. Londonderry
BT52 1SA

phone: +44 28 70124419
Email: pr.flatt@ulster.ac.uk

Flatt, Peter Professor - Publications

Number of items: 471.

Moran, BM, Abdel-Wahab, Yasser, Flatt, Peter and Mckillop, Aine (2014) Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreatic β-cells.. Diabetes Obesity and Metabolism, 16 (11). pp. 1128-1139.

Ojo, Opeolu, Srinivasan, DK, Owolabi, BO, Conlon, JM, Flatt, Peter and Abdel-Wahab, Yasser (2014) Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice.. Biochim Biophys Acta, 1850 (1). pp. 80-87.

Mckillop, Aine, Ng, MT, Abdel-Wahab, Yasser and Flatt, Peter (2014) Evidence for inhibitory autocrine effects of proinsulin C-peptide on pancreatic β-cell function and insulin secretion.. Diabetes Obesity and Metabolsim, 16 (10). pp. 937-946.

Lynch, AM, Patahk, P, Flatt, YE, Gault, Victor, O'Harte, Finbarr, Irwin, Nigel and Flatt, Peter (2014) Comparison of stability, cellular, glucose-lowering and appetite supressing effects of oxyntomodulin analogues modified at the N-terminus. European Journal of Pharmacology, 743. pp. 69-78.

Lennox, R, Porter, DW, Flatt, Peter, Holscher, C, Irwin, Nigel and Gault, Victor (2014) Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice.. Neuropharmacology, 86C. pp. 22-30.

Vasu, Srividya, Moffett, RC, Thorens, B and Flatt, Peter (2014) Role of Endogenous GLP-1 and GIP in Beta Cell Compensatory Responses to Insulin Resistance and Cellular Stress.. PLoS One, 9. pp. e101005.

Lynch, AM, Pathak, N, Pathak, V, O'Harte, Finbarr, Flatt, Peter, Irwin, Nigel and Gault, Victor (2014) A novel DPP IV-resistant C-terminally extended glucagon analogue exhibits weight-lowering and diabetes-protective effects in high-fat-fed mice mediated through glucagon and GLP-1 receptor activation.. Diabetologia, 57 (9). pp. 1927-1936.

Moffett, RC, Vasu, Srividya, Thorens, B, Drucker, DJ and Flatt, Peter (2014) Incretin Receptor Null Mice Reveal Key Role of GLP-1 but Not GIP in Pancreatic Beta Cell Adaptation to Pregnancy.. PLoS ONE, 9. pp. e96863.

Conlon, JM, Mechkarska, M, Lukic, ML and Flatt, Peter (2014) Potential therapeutic applications of multifunctional host-defense peptides from frog skin as anti-cancer, anti-viral, immunomodulatory, and anti-diabetic agents. Peptides, 57. pp. 67-77.

Martin, CA, Parthsarathy, V, Pathak, V, Gault, Victor, Flatt, Peter and Irwin, Nigel (2014) Characterisation of the biological activity of xenin-25 degradation fragment peptides. Journal of Endocrinology, 221 (2). pp. 193-200.

Pathak, V, Vasu, S, Flatt, Peter and Irwin, Nigel (2014) Effects of chronic exposure of clonal beta-cells to elevated glucose and free fatty acids on incretin receptor gene expression and secretory responses to GIP and GLP-1.. Diabetes Obesity and Metabolism, 16 (4). pp. 357-365.

Moran, BM, Abdel-Wahab, Yasser, Flatt, Peter and Mckillop, Aine (2014) Activation of GPR119 by fatty acid agonists augments insulin release from clonal β-cells and isolated pancreatic islets and improves glucose tolerance in mice. Biological Chemistry, 395 (4). pp. 453-464.

Mabilleau, G, Mieczkowska , A, Irwin, Nigel, Simon Y, Y, Audran , M, Flatt, Peter and Chappard D, D (2014) Beneficial effects of a N-terminally modified GIP agonist on tissue-level bone material properties.. Bone, 63. pp. 61-68.

Srinivasan , D, Ojo, Opeolu, Abdel-Wahab, Yasser, Flatt, Peter, Guilhaudis , L and Conlon, JM (2014) Insulin-releasing and cytotoxic properties of the frog skin peptide, tigerinin-1R: a structure-activity study. Peptides, 55. pp. 23-31.

Gault, Victor, Bhat, VK, Irwin, Nigel and Flatt, Peter (2013) A novel GLP-1/glucagon hybrid peptide with triple-acting agonist activity at GIP, GLP-1 and glucagon receptors and therapeutic potential in high-fat fed mice.. Journal of Biological Chemistry, 288 (49). pp. 35581-35591.

Irwin, Nigel and Flatt, Peter (2013) Enteroendocrine hormone mimetics for the treatment of obesity and diabetes.. Current Opinion in Pharmacology, 13 (6). pp. 989-995.

Moffett, RC, Irwin, Nigel, Francis, JME and Flatt, Peter (2013) Alterations of Glucose-Dependent Insulinotropic Polypeptide and Expression of Genes Involved in Mammary Gland and Adipose Tissue Lipid Metabolism during Pregnancy and Lactation . PLoS ONE, 8 (11). pp. 78560-78560.

Vasu, S, Moffett, RC, McCluskey, Janie, Hamid, MH, Irwin, Nigel and Flatt, Peter (2013) Beneficial effects of parenteral GLP-1 delivery by cell therapy in insulin-deficient streptozotocin diabetic mice. Gene Therapy, 20 (11). pp. 1077-1084.

Vasu, Srividya, McClenaghan, Neville, McCluskey, Janie and Flatt, Peter (2013) Mechanisms of toxicity by proinflammatory cytokines in a novel human pancreatic beta cell line, 1.1B4.. Biochimica et Biophysica Acta , 1840 (1). pp. 136-145.

Vasu, S, McClenaghan, Neville, McCluskey, Janie and Flatt, Peter (2013) Cellular responses of novel human pancreatic β-cell line, 1.1B4 to hyperglycemia.. Islets, 5 (4). pp. 0-0.

Mckillop, Aine, Moran, BM, Abdel-Wahab, Yasser and Flatt, Peter (2013) Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice.. British Journal of Pharmacology, 170 (5). pp. 978-990.

Mabilleau, G, Mieczkowska, A, Irwin, Nigel, Flatt, Peter and Chappard, D (2013) Optimal bone mechanical and material properties require a functional GLP-1 receptor. Journal of Endocrinology, 219 (1). pp. 59-68.

Martin, CM, Irwin, Nigel, Flatt, Peter and Gault, Victor (2013) A novel acylated form of (d-Ala2)GIP with improved antidiabetic potential, lacking effect on body fat stores. Biochimica et Biophysica Acta, 1830 (6). pp. 3407-3413.

Mieczkowska, A, Irwin, Nigel, Flatt, Peter, Chappard , D and Mabilleau, G (2013) Glucose-dependent insulinotropic polypeptide (GIP) receptor deletion leads to reduced bone strength and quality. Bone, 56 (2). pp. 337-342.

Ojo, OO, Abdel-Wahab, Yasser, Flatt, Peter and Conlon, JM (2013) Insulinotropic Actions of the Frog Skin Host-Defense Peptide Alyteserin-2a: A Structure-Activity Study. Chemical Biology & Drug Design , 82 (2). pp. 196-204.

Porter, DW, Flatt, Peter, Holscher, Christian and Gault, Victor (2013) Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice.. International Journal of Obesity, 37 (5). pp. 678-684.

Irwin, Nigel, Frizelle, P, O'Harte, Finbarr and Flatt, Peter (2013) (pGlu-Gln)-CCK-8[mPEG]: A novel, long-acting, mini-PEGylated cholecystokinin (CCK) agonist that improves metabolic status in dietary-induced diabetes. Biochimica et Biophysica Acta - General Subjects, 1830 (8). pp. 4009-4016.

Bhat, VK, Kerr, BD, Flatt, Peter and Gault, Victor (2013) A novel GIP-Oxyntomodulin hybrid peptide acting through GIP, glucagon and GLP-1 receptors exhibits weight reducing and anti-diabetic properties.. Biochemical Pharmacology, 85 (11). pp. 1655-1662.

Bhat, VK, Kerr, BD, Vasu, S, Flatt, Peter and Gault, Victor (2013) A DPP-IV-resistant triple-acting agonist of GIP, GLP-1 and glucagon receptors with potent glucose-lowering and insulinotropic actions in high-fat-fed mice.. Diabetologia, 56 (6). pp. 1417-1424.

Irwin, Nigel, Montgomery, IA and Flatt, Peter (2013) Comparison of the metabolic effects of sustained CCK1 receptor activation alone and in combination with upregulated leptin signalling in high-fat-fed mice. Diabetologia, 56 (6). pp. 1425-1435.

Vasu, S, McClenaghan, Neville, McCluskey, Janie and Flatt, Peter (2013) Effects of lipotoxicity on novel insulin secreting human pancreatic β-cell line, 1.1B4.. Biological Chemistry, 394 (7). pp. 909-918.

Lennox, R, Porter, DW, Flatt, Peter and Gault, Victor (2013) (Val(8) )GLP-1-Glu-PAL: a GLP-1 Agonist That Improves Hippocampal Neurogenesis, Glucose Homeostasis, and β-Cell Function in High-Fat-Fed Mice.. ChemMedChem, 8 (4). pp. 595-602.

Gaudin-Audrain, C, Irwin, Nigel, Mansur, S, Flatt, Peter, Thorens, B, Basle, M, Chappard, D and Mabilleau, G (2013) Glucose-dependent insulinotropic polypeptide receptor deficiency leads to modifications of trabecular bone volume and quality in mice. Bone, 53 (1). pp. 221-230.

Srinivasan , D, Mechkarska , M, Abdel-Wahab, Yasser, Flatt, Peter and Conlon, JM (2013) Caerulein precursor fragment (CPF) peptides from the skin secretions of Xenopus laevis and Silurana epitropicalis are potent insulin-releasing agents.. Biochimie, 95 (2). pp. 429-435.

Montgomery, IA, Irwin, Nigel and Flatt, Peter (2013) Beneficial Effects of (pGlu-Gln)-CCK-8 on Energy Intake and Metabolism in High Fat Fed Mice are Associated with Alterations of Hypothalamic Gene Expression.. Hormone and Metabolic Research, 45 (6). pp. 471-473.

Irwin, Nigel, Hunter, K, Montgomery, IA and Flatt, Peter (2013) Comparison of independent and combined metabolic effects of chronic treatment with (pGlu-Gln)-CCK-8 and long-acting GLP-1 and GIP mimetics in high fat fed mice.. Diabetes Obesity and Matabolism, 15 (7). pp. 650-659.

Ojo, OO, Conlon, JM, Flatt, Peter and Abdel-Wahab, Yasser (2013) Frog skin peptides (tigerinin-1R, magainin-AM1, -AM2, CPF-AM1, and PGla-AM1) stimulate secretion of glucagon-like peptide 1 (GLP-1) by GLUTag cells.. Biochemical and Biophysical Research Communications, 431. pp. 14-18.

Irwin, Nigel, Frizzelle, P, O'Harte, Finbarr and Flatt, Peter (2013) Metabolic effects of activation of CCK receptor signaling pathways by twice daily administration of the enzyme resistant CCK-8 analogue, (pGlu-Gln)-CCK-8, in normal mice.. Journal of Endocrinology, 216 (1). pp. 53-59.

Irwin, Nigel and Flatt, Peter (2013) GIP. In: Handbook of Biologically Active Peptides (2nd Edition). Elsevier, pp. 1227-1235. ISBN 978-0-12-385095-9

Ojo, OO, Flatt, Peter, Abdel-Wahab, Yasser and Conlon, JM (2013) Insulin-Releasing Peptides. In: Handbook of Biologically Active Peptides (2nd Edition). Elsevier, pp. 364-370. ISBN 978-0-12-385095-9

Hsu, YS, Kuo, YH, Cheng, HL, Flatt, Peter and Liu, HK (2012) Schizandra arisanensis extract attenuates cytokine-mediated cytotoxicity in insulin-secreting cells.. World Journal of Gastroenterolog , 18 (46). pp. 6809-6818.

Irwin, Nigel, Montgomery, IA, O'Harte, Finbarr, Frizelle, P and Flatt, Peter (2012) Comparison of the independent and combined metabolic effects of subchronic modulation of CCK and GIP receptor action in obesity-related diabetes. International Journal of Obesity, 37 (8). pp. 1058-1063.

Irwin, Nigel, Montgomery, IA, Moffett, RC and Flatt, Peter (2012) Chemical cholecystokinin receptor activation protects against obesity-diabetes in high fat fed mice and has sustainable beneficial effects in genetic ob/ob mice.. Biochemical Pharmacology, 85. pp. 81-91.

Martin, Christine M.A., Gault, Victor, McClean, Stephen, Flatt, Peter and Irwin, Nigel (2012) Degradation, insulin secretion, glucose-lowering and GIP additive actions of a palmitate-derivatised analogue of xenin-25. Biochemical Pharmacology, 84 (3). pp. 312- 319.

Scullion, S. M. J., Gurgul-Convey, E., Elsner, M., Lenzen, S., Flatt, Peter and McClenaghan, Neville (2012) Enhancement of homocysteine toxicity to insulin-secreting BRIN-BD11 cells in combination with alloxan. JOURNAL OF ENDOCRINOLOGY, 214 (2). pp. 233-238.

Irwin, Nigel, Frizelle, P, Montgomery, IA, Moffett, RC, O'Harte, Finbarr and Flatt, Peter (2012) Beneficial effects of the novel cholecystokinin agonist (pGlu-Gln)-CCK-8 in mouse models of obesity/diabetes. Diabetologia, 55 (10). pp. 2747-2758.

da Silva Krause , M, Bittencourt , A, Homem de Bittencourt , PI jr, McClenaghan, Neville, Flatt, Peter, Murphy , C and Newsholme , P (2012) Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic β-cell line and mouse islets.. Journal of Endocrinology, 214 (3). pp. 301-311.

Irwin, Nigel, Montgomery, Ian A. and Flatt, Peter (2012) Evaluation of the long-term effects of gastric inhibitory polypeptide-ovalbumin conjugates on insulin resistance, metabolic dysfunction, energy balance and cognition in high-fat-fed mice. BRITISH JOURNAL OF NUTRITION, 108 (1). pp. 46-56.

Guo-Parke, H, McCluskey, Janie, Kelly , C, Hamid , M, McClenaghan, Neville and Flatt, Peter (2012) Configuration of electrofusion-derived human insulin-secreting cell line as pseudoislets enhances functionality and therapeutic utility.. Journal of Endocrinology , 214 (3). pp. 257-265.

Porter, David, Faivre, Emilie, Flatt, Peter, Holscher, Christian and Gault, Victor (2012) Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice. PEPTIDES, 35 (1). pp. 1-8.

Hannan, J. M. A., Ali, Liaquat, Khaleque, Junaida, Akhter, Masfida, Flatt, Peter and Abdel-Wahab, Yasser (2012) Antihyperglycaemic activity of Asparagus racemosus roots is partly mediated by inhibition of carbohydrate digestion and absorption, and enhancement of cellular insulin action. BRITISH JOURNAL OF NUTRITION, 107 (9). pp. 1316-1323.

Guo-Parke, H., McCluskey, Janie, Kelly, Catriona, Hamid, M., McClenaghan, Neville and Flatt, Peter (2012) Configuration of electrofusion-derived human insulin-secreting cell line as pseudoislets enhances functionality and therapeutic utility. Journal of Endocrinology, 214 (3). pp. 257.

Abed, Arif, Critchlow, Charlotte, Flatt, Peter, McClenaghan, Neville and Kelly, Catriona (2012) Directed differentiation of progenitor cells towards an islet-cell phenotype.. Am J Stem Cells., 1(3). pp. 196-204.

McClenaghan, Neville, Flatt, Peter, Harper, AGS and Kelly, Catriona (2012) Establishment of an F508del pseudoislet model for the study of CF-related diabetes. Journal of Cystic Fibrosis, 11. pp. S117.

Ojo, O. O., Abdel-Wahab, Yasser, Flatt, Peter, Mechkarska, M. and Conlon, J. M. (2011) Tigerinin-1R: a potent, non-toxic insulin-releasing peptide isolated from the skin of the Asian frog, Hoplobatrachus rugulosus. DIABETES OBESITY and METABOLISM, 13 (12). pp. 1114-1122.

Mckillop, Aine and Flatt, Peter (2011) Emerging Applications of Metabolomic and Genomic Profiling in Diabetic Clinical Medicine. DIABETES CARE, 34 (12). pp. 2624-2630.

Irwin, Nigel, Francis, Jacqueline M. E. and Flatt, Peter (2011) Insulin modulates glucose-dependent insulinotropic polypeptide (GIP) secretion from enteroendocrine K cells in rats. BIOLOGICAL CHEMISTRY, 392 (10). pp. 909-918.

Krause, MS, McClenaghan, Neville, Flatt, Peter, de Bittencourt, PIH, Murphy, C and Newsholme, P (2011) L-Arginine is essential for pancreatic beta-cell functional integrity, metabolism and defense from inflammatory challenge. JOURNAL OF ENDOCRINOLOGY, 211 (1). pp. 87-97.

Franklin, Z. J., McDonnell, B., Montgomery, I. A., Flatt, Peter and Irwin, Nigel (2011) Dual modulation of GIP and glucagon action by the low molecular weight compound 4-hydroxybenzoic acid 2-bromobenzylidene hydrazide. DIABETES OBESITY & METABOLISM, 13 (8). pp. 742-749.

Gault, Victor, Kerr, Barry D., Harriott, Patrick and Flatt, Peter (2011) Administration of an acylated GLP-I and GIP preparation provides added beneficial glucose-lowering and insulinotropic actions over single incretins in mice with Type 2 diabetes and obesity. CLINICAL SCIENCE, 121 (3-4). pp. 107-117.

Paget, M. B., Murray, H. E., Bailey, C. J., Flatt, Peter and Downing, R. (2011) Rotational co-culture of clonal beta-cells with endothelial cells: effect of PPAR-gamma agonism in vitro on insulin and VEGF secretion. DIABETES OBESITY & METABOLISM, 13 (7). pp. 662-668.

Zahid, Osama K., Mechkarska, Milena, Ojo, Opeolu O., Abdel-Wahab, Yasser, Flatt, Peter, Meetani, Mohammed A. and Conlon, J. Michael (2011) Caerulein-and xenopsin-related peptides with insulin-releasing activities from skin secretions of the clawed frogs, Xenopus borealis and Xenopus amieti (Pipidae). GENERAL AND COMPARATIVE ENDOCRINOLOGY, 172 (2). pp. 314-320.

McCluskey, Janie, Hamid, Muhajir, Guo-Parke, Hong, McClenaghan, Neville, Gomis, Ramon and Flatt, Peter (2011) Development and Functional Characterization of Insulin-releasing Human Pancreatic Beta Cell Lines Produced by Electrofusion. JOURNAL OF BIOLOGICAL CHEMISTRY, 286 (25). pp. 21982-21992.

Irwin, Nigel, McKinney, J. M., Bailey, C. J., McClenaghan, Neville and Flatt, Peter (2011) Acute and Long-term Effects of Peroxisome Proliferator-activated Receptor-gamma Activation on the Function and Insulin Secretory Responsiveness of Clonal Beta-Cells. HORMONE AND METABOLIC RESEARCH, 43 (4). pp. 244-249.

Gault, Victor, Porter, David W., Irwin, Nigel and Flatt, Peter (2011) Comparison of sub-chronic metabolic effects of stable forms of naturally occurring GIP(1-30) and GIP(1-42) in high-fat fed mice. JOURNAL OF ENDOCRINOLOGY, 208 (3). pp. 265-271.

Kelly, Catriona, McClenaghan, Neville H. and Flatt, Peter (2011) Role of islet structure and cellular interactions in the control of insulin secretion. ISLETS, 3 (2). pp. 41-47.

Irwin, Nigel, Francis, J. M. E. and Flatt, Peter (2011) Alterations of glucose-dependent insulinotropic polypeptide (GIP) during cold acclimation. REGULATORY PEPTIDES, 167 (1). pp. 91-96.

Mechkarska, Milena, Ojo, Opeolu O., Meetani, Mohammed A., Coquet, Laurent, Jouenne, Thierry, Abdel-Wahab, Yasser, Flatt, Peter, King, Jay D. and Conlon, J. Michael (2011) Peptidomic analysis of skin secretions from the bullfrog Lithobates catesbeianus (Ranidae) identifies multiple peptides with potent insulin-releasing activity. PEPTIDES, 32 (2). pp. 203-208.

Kerr, Barry D., Flatt, Anneliese J. S., Flatt, Peter and Gault, Victor (2011) Characterization and biological actions of N-terminal truncated forms of glucose-dependent insulinotropic polypeptide. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 404 (3). pp. 870-876.

Mckillop, Aine, Ng, MT, Flatt, Peter and Abdel-Wahab, Yasser (2011) Autocrine inhibitory effects of proinsulin C-peptide and insulin on insulin secretion and pancreatic beta cell function . Diabetologia, 54. pp. S258.

Kelly, Catriona, McClenaghan, Neville and Flatt, Peter (2011) Role of islet structure and cellular interactions in the control of insulin secretion.. Islets. , 3(2). pp. 41-47.

Irwin, Nigel, McKinney, J. M., Bailey, C. J., Flatt, Peter and McClenaghan, Neville (2010) Effects of metformin on BRIN-BD11 beta-cell insulin secretory desensitization induced by prolonged exposure to sulphonylureas. DIABETES OBESITY & METABOLISM, 12 (12). pp. 1066-1071.

Kerr, Barry D., Flatt, Peter and Gault, Victor (2010) (D-Ser(2))Oxm[mPEG-PAL]: A novel chemically modified analogue of oxyntomodulin with antihyperglycaemic, insulinotropic and anorexigenic actions. BIOCHEMICAL PHARMACOLOGY, 80 (11). pp. 1727-1735.

McKiney, Joan M., Irwin, Nigel, Flatt, Peter, Bailey, Clifford J. and McClenaghan, Neville (2010) Acute and long-term effects of metformin on the function and insulin secretory responsiveness of clonal beta-cells. BIOLOGICAL CHEMISTRY, 391 (12). pp. 1451-1459.

McCluskey, Janie, Vasu, S., Hamid, M. H., Irwin, Nigel and Flatt, Peter (2010) Functional analysis of the GLP-1 secreting GLUTag cell line in vitro and in normal and diabetic SCID mice. IRISH JOURNAL OF MEDICAL SCIENCE, 179 (Suppl. 13). pp. 537.

Porter, D. W., Kerr, B. D., Flatt, Peter, Holscher, Christian and Gault, Victor (2010) Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance. DIABETES OBESITY & METABOLISM, 12 (10). pp. 891-899.

Kelly, Catriona, Guo, Hong, McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2010) Comparison of Insulin Release From MIN6 Pseudoislets and Pancreatic Islets of Langerhans Reveals Importance of Homotypic Cell Interactions. PANCREAS, 39 (7). pp. 1016-1023.

Taylor, Ashley, Irwin, Nigel, McKillop, Aine, Patterson, Steven, Flatt, Peter and Gault, Victor (2010) Evaluation of the degradation and metabolic effects of the gut peptide xenin on insulin secretion, glycaemic control and satiety. JOURNAL OF ENDOCRINOLOGY, 207 (1). pp. 87-93.

Kelly, Catriona, Parke, Hong Guo, McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2010) The role of glucagon- and somatostatin-secreting cells in the regulation of insulin release and beta-cell function in heterotypic pseudoislets. DIABETES-METABOLISM RESEARCH AND REVIEWS, 26 (7). pp. 525-533.

Montgomery, I. A., Irwin, Nigel and Flatt, Peter (2010) Active immunization against (Pro3)GIP improves metabolic status in high-fat-fed mice. DIABETES OBESITY AND METABOLISM, 12 (9). pp. 744-751.

Hunter, Kerry, O'Harte, FPM, Abdel-Wahab, YHA and Flatt, PR (2010) Evaluation of the inhibitory action of islet amyloid polypeptide on insulin secretion from clonal rat pancreatic beta-cells. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 44.

Subasinghage, Anusha P., Green, Brian D., Flatt, Peter, Irwin, Nigel and Hewage, Chandralal M. (2010) Metabolic and structural properties of human obestatin {1-23} and two fragment peptides. PEPTIDES, 31 (9). pp. 1697-1705.

Abdel-Wahab, Yasser, Flatt, Peter, Patterson, S. and Conlon, J. M. (2010) Insulin-releasing properties of the frog skin peptide B2RP (brevinin-2 related peptide) and its analogues both in vitro and in vivo. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 51.

Gault, Victor, Kerr, B. D. and Flatt, Peter (2010) Investigating the role of the glutamyl linker on the biological efficacy of Liraglutide. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 44-45.

Irwin, Nigel, Porter, W. D., Flatt, Peter, Holscher, Christian and Gault, Victor (2010) Prolonged GIP receptor activation improves glucose homeostasis and cognitive function in high-fat fed mice. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 44.

McKillop, Aine, Ng, MT, Flatt, Peter and Abdel-Wahab, Yasser (2010) Involvement of proinsulin C-peptide in the regulation of pancreatic beta cell function and glucose homeostasis. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 43.

Moffett, R. C., Patterson, S. and Flatt, Peter (2010) Effects of Liraglutide on glycaemic control and pancreatic islet morphology in C57BL/KsJ db/db mice with degenerative diabetes. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 43.

Montgomery, I. A., Irwin, Nigel and Flatt, Peter (2010) The metabolic effects of induction of GIP neutralising antibodies in high-fat fed mice. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 42.

Taylor, Ashley, Irwin, Nigel, McKillop, Aine, Flatt, Peter and Gault, Victor (2010) Xenin: An anorectic peptide involved in insulin secretion and glucose homeostasis. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 41.

Porter, W. D., Kerr, B. D., Flatt, Peter, Holscher, Christian and Gault, Victor (2010) The glucagon-like peptide-1 agonist Liraglutide improves memory and learning in obese-diabetic mice. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 40.

Ojo, O. O., Flatt, Peter, Conlon, M. J. and Abdel-Wahab, Yasser (2010) Isolation and structural characterization of novel insulinotropic peptides from skin secretions of Xenopus amieti. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 36-37.

Kerr, B. D., Flatt, Peter and Gault, Victor (2010) A novel analogue of oxyntomodulin with improved glucose-lowering, insulinotropic and anorexigenic actions. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 33.

Kelly, C., Parke, H. Guo, McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2010) Evaluation of role of islet cell paracrine interactions in regulation of insulin secretion using a new heterotypic pseudoislet model. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 33.

Vasu, S., Hamid, M. H., McCluskey, Janie, Irwin, Nigel and Flatt, Peter (2010) Implantation of GLP-1 secreting cells fails to recapitulate effects of exogenous GLP-1 mimetics in mice. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 32.

Irwin, Nigel, Taylor, Ashley, Flatt, Peter and Gault, Victor (2010) Assessment of the metabolic effects of the gut peptide xenin on insulin secretion, glycaemic control and satiety. DIABETOLOGIA, 53 (Suppl. 1). pp. 22.

Gault, Victor, Kerr, B. D. and Flatt, Peter (2010) Improved glucose-lowering, insulin-releasing and anorexigenic actions of a novel chemically modified analogue of oxyntomodulin, (D-Ser(2))Oxm[mPEG-PAL]. DIABETOLOGIA, 53 (Suppl. 1). pp. 20.

Irwin, Nigel, Gault, Victor and Flatt, Peter (2010) Therapeutic potential of the original incretin hormone glucose-dependent insulinotropic polypeptide: diabetes, obesity, osteoporosis and Alzheimer's disease?. EXPERT OPINION ON INVESTIGATIONAL DRUGS, 19 (9). pp. 1039-1048.

Kerr, Barry D., Flatt, Peter and Gault, Victor (2010) Effects of gamma-glutamyl linker on DPP-IV resistance, duration of action and biological efficacy of acylated glucagon-like peptide-1. BIOCHEMICAL PHARMACOLOGY, 80 (3). pp. 396-401.

Gault, Victor, Porter, W. D., Flatt, Peter and Holscher, Christian (2010) Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet. INTERNATIONAL JOURNAL OF OBESITY, 34 (8). pp. 1341-1344.

Kelly, Catriona, Flatt, Peter and McClenaghan, Neville (2010) Cell-to-cell communication and cellular environment alter the somatostatin status of delta cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 399 (2). pp. 162-166.

Kasabri, Violet, Flatt, Peter and Abdel-Wahab, Yasser (2010) Emblica officinalis stimulates the secretion and action of insulin and inhibits starch digestion and protein glycation. ENDOCRINE JOURNAL, 57 (Suppl. 2). pp. S367.

Irwin, Nigel, Flatt, Peter, Patterson, Steven and Green, BD (2010) Insulin-releasing and metabolic effects of small molecule GLP-1 receptor agonist 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline.. European Journal of Pharmacology , 628 (1-3). pp. 268-273.

Porter, David, Irwin, Nigel, Flatt, Peter, Holscher, Christian and Gault, Victor (2010) Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high fat fed mice. Eur J Pharmacol, 650. pp. 688-693.

Kasabri, V, Flatt, Peter and Abdel-Wahab, Yasser (2010) Terminalia bellirica stimulates the secretion and action of insulin and inhibits starch digestion and protein glycation in vitro.. British Journal of Nutrition , 103 (2). pp. 212-217.

Abdel-Wahab, Yasser, Patterson, Steven, Flatt, Peter and Conlon, M (2010) Brevinin-2-related peptide and its [D4K] analogue stimulate insulin release in vitro and improve glucose tolerance in mice fed a high fat diet.. Hormone and Metabolic Research, 42(9). pp. 652-656.

Bailey, CJ, Green, BD and Flatt, Peter (2010) Fixed-dose combination therapy for type 2 diabetes: sitagliptin plus pioglitazone. Expert Opinion on Investigational Drugs, 19(8). pp. 1017-1025.

Mckillop, Aine, Ng, MT, Flatt, Peter and Abdel-Wahab, Yasser (2010) Regulatory role for proinsulin C-peptide in pancreatic beta cell function and glucose homeostasis. . Irish Journal of Medical Science, 179. pp. 83.

Kelly, Catriona, Guo, Hong, McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2010) Comparison of Insulin Release From MIN6 Pseudoislets and Pancreatic Islets of Langerhans Reveals Importance of Homotypic Cell Interactions. Pancreas, 39 (7). pp. 1016.

Kelly, Catriona, Flatt, Peter and McClenaghan, Neville (2010) Cell-to-cell communication and cellular environment alter the somatostatin status of delta cells. Biochemical and Biophysical Research Communications, 399 (2). pp. 162.

Kelly, Catriona, Parke, Hong Guo, McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2010) The role of glucagon- and somatostatin-secreting cells in the regulation of insulin release and beta-cell function in heterotypic pseudoislets. Diabetes/Metabolism Research and Reviews, 26 (7). pp. 525.

Bender, Katrin, Maechler, Pierre, McClenaghan, Neville H., Flatt, Peter and Newsholme, Philip (2009) Overexpression of the malate-aspartate NADH shuttle member Aralar 1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism. CLINICAL SCIENCE, 117 (9-10). pp. 321-330.

Kerr, Barry D, Irwin, Nigel, O'Harte, Finbarr, Bailey, Clifford J, Flatt, Peter and Gault, Victor (2009) Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. BIOCHEMICAL PHARMACOLOGY, 78 (8). pp. 1008-1016.

Mckillop, Aine, Ng, MT, Flatt, Peter and Abdel-Wahab, Yasser (2009) Evidence for inhibitory autocrine effects of proinsulin C-peptide on pancreatic beta cell function and insulin secretion . DIABETOLOGIA , 52. pp. S167-S167.

McKillop, Aine, Duffy, NA, Lindsay, JR, Green, BD, Patterson, Steven, O'Harte, Finbarr, Bell, PM and Flatt, Peter (2009) Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation.. European Journal of Endocrinology, 16 (6). pp. 877-885.

Irwin, Nigel and Flatt, Peter (2009) Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications. DIABETOLOGIA, 52 (9). pp. 1724-1731.

Patterson, Steven, Irwin, Nigel, Green, B. D. and Flatt, Peter (2009) Insulinotropic and glucose lowering effects of small molecule GLP-1-receptor agonist 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline. DIABETOLOGIA, 52 (Suppl. 1). pp. 787.

Gault, Victor, Kerr, BD, Irwin, Nigel, O'Harte, Finbarr and Flatt, Peter (2009) Fatty acid derivatised forms of glucose-dependent insulinotropic polypeptide with improved glucose-lowering and insulin-releasing properties. DIABETOLOGIA, 52 (Suppl. 1). pp. 786.

Mckillop, Aine, Ng, MT, Flatt, Peter and Abdel-Wahab, Yasser (2009) Evidence for inhibitory autocrine effects of proinsulin C-peptide on pancreatic beta cell function and insulin secretion. DIABETOLOGIA, 52 (Suppl. 1). pp. 406.

Taylor, AI, Frizzell, N, McKillop, Aine, Flatt, Peter and Gault, Victor (2009) Effect of RU486 on hepatic and adipocyte gene expression improves diabetes control in obesity-type 2 diabetes.. Hormone Metabolic Research , 41 (12). pp. 899-904.

Irwin, Nigel and Flatt, Peter (2009) Therapeutic potential for GIP receptor agonists and antagonists. BEST PRACTICE AND RESEARCH CLINICAL ENDOCRINOLOGY AND METABOLISM, 23 (4). pp. 499-512.

Green, Brian D., Irwin, Nigel and Flatt, Peter (2009) Metabolic responses of obestatin peptides in normal and high-fat fed mice. AMINO ACIDS, 37 (Suppl. 1). pp. 9.

Kiely A, A, Robinson A, A, McClenaghan, Neville H., Flatt, Peter and Newsholme P, P (2009) Toll-like receptor agonist induced changes in clonal rat BRIN-BD11 beta-cell insulin secretion and signal transduction.. Journal of Endocrinology, 202 (3). pp. 365-373.

Irwin, Nigel, McClean, Paula, Hunter, Kerry and Flatt, Peter (2009) Metabolic effects of sustained activation of the GLP-1 receptor alone and in combination with background GIP receptor antagonism in high fat-fed mice. DIABETES OBESITY AND METABOLISM, 11 (6). pp. 603-610.

Conlon, J. Michael, Abdel-Wahab, Yasser, Flatt, Peter, Leprince, Jerome, Vaudry, Hubert, Jouenne, Thierry and Condamine, Eric (2009) A glycine-leucine-rich peptide structurally related to the plasticins from skin secretions of the frog Leptodactylus laticeps (Leptodactylidae). PEPTIDES, 30 (5). pp. 888-892.

Kerr, Barry D., Irwin, Nigel, Flatt, Peter and Gault, Victor (2009) Prolonged GIP receptor activation using stable mini-PEGylated GIP improves glucose homeostasis and beta-cell function in age-related glucose intolerance. PEPTIDES, 30 (2). pp. 219-225.

McClenaghan, Neville, Scullion, Siobhan M., Mion, Brian, Hewage, Chandralal, Malthouse, J. Paul G., Flatt, Peter, Newsholme, Philip and Brennan, Lorraine (2009) Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic beta-cells. CLINICAL SCIENCE, 116 (3-4). pp. 341-351.

Flatt, Peter, Bailey, C. J. and Green, B. D. (2009) Recent Advances in Antidiabetic Drug Therapies Targeting the Enteroinsular Axis. CURRENT DRUG METABOLISM, 10 (2). pp. 125-137.

Irwin, Nigel, Hunter, Kerry, Frizzell, Norma and Flatt, Peter (2009) Antidiabetic effects of sub-chronic activation of the GIP receptor alone and in combination with background exendin-4 therapy in high fat fed mice. REGULATORY PEPTIDES, 153 (1-3). pp. 70-76.

Irwin, Nigel, McClean, Paula, Patterson, Steven, Hunter, Kerry and Flatt, Peter (2009) Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes. BIOLOGICAL CHEMISTRY, 390 (1). pp. 75-80.

O'Harte, Finbarr, Kerr, BD, Irwin, Nigel, Gault, Victor and Flatt, Peter (2009) GIP(Lys37MYR), a novel acylated analogue of glucose-dependent insulinotropic polypeptide (GIP) has enhanced stability, glucose lowering and insulin releasing properties in obese diabetic (ob/ob) mice. Irish Journal of Medical Science, 178 (S10). pp. 389-389.

Ng, MT, Abdel-Wahab, Yasser, Flatt, Peter and Mckillop, Aine (2009) Autocrine effects of C-peptide on pancreatic beta cell function and insulin secretion in BRIN-BD11 cells and isolated islets . Irish Journal of Medical Science, 178. pp. S391.

Abdel-Wahab, Yasser, Power, Gavin J., Flatt, Peter, Woodhams, Douglas C., Rollins-Smith, Louise A. and Conlon, J. Michael (2008) A peptide of the phylloseptin family from the skin of the frog Hylomantis lemur (Phyllomedusinae) with potent in vitro and in vivo insulin-releasing activity. PEPTIDES, 29 (12). pp. 2136-2143.

Conlon, J. Michael, Power, Gavin J., Abdel-Wahab, Yasser, Flatt, Peter, Jiansheng, Hu, Coquet, Laurent, Leprince, Jerome, Jouenne, Thierry and Vaudry, Hubert (2008) A potent, non-toxic insulin-releasing peptide isolated from an extract of the skin of the Asian frog, Hylarana guntheri (Anura:Ranidae). REGULATORY PEPTIDES, 151 (1-3). pp. 153-159.

McClean, Paula, Irwin, Nigel, Hunter, Kerry, Gault, Victor and Flatt, Peter (2008) (Pro(3)) GIP[mPEG]: novel, long-acting, mPEGylated antagonist of gastric inhibitory polypeptide for obesity-diabetes (diabesity) therapy. BRITISH JOURNAL OF PHARMACOLOGY, 155 (5). pp. 690-701.

O'Harte, Finbarr, Frizelle, PA and Flatt, Peter (2008) Peripheral N-acetylated cholecystokinin-8 administration has more potent effect in reducing short term food intake than peptide YY in mice. DIABETOLOGIA, 51 (Suppl. 1). pp. 124.

Flatt, Peter (2008) Dorothy Hodgkin Lecture 2008 Gastric inhibitory polypeptide (GIP) revisited: a new therapeutic target for obesity-diabetes?. DIABETIC MEDICINE, 25 (7). pp. 759-764.

Gault, Victor, Kerr, Barry D., Irwin, Nigel and Flatt, Peter (2008) C-terminal mini-PEGylation of glucose-dependent insulinotropic polypeptide exhibits metabolic stability and improved glucose homeostasis in dietary-induced diabetes. BIOCHEMICAL PHARMACOLOGY, 75 (12). pp. 2325-2333.

Irwin, Nigel, Hunter, Kerry and Flatt, Peter (2008) Comparison of independent and combined chronic metabolic effects of GIP and CB1 receptor blockade in high-fat fed mice. PEPTIDES, 29 (6). pp. 1036-1041.

Flatt, Peter, Bailey, Clifford J. and Green, Brian D. (2008) Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes. FRONTIERS IN BIOSCIENCE, 13. pp. 3648-3660.

McClean, Paula, Gault, Victor, Irwin, Nigel, McCluskey, Janie and Flatt, Peter (2008) Daily administration of the GIP-R antagonist (Pro(3))GIP in streptozotocin-induced diabetes suggests that insulin-dependent mechanisms are critical to anti-obesity-diabetes actions of (Pro(3))GIP. DIABETES OBESITY AND METABOLISM, 10 (4). pp. 336-342.

Liu, Hui-Kang, McCluskey, Janie, McClenaghan, Neville and Flatt, Peter (2008) Iterative exposure of clonal BRIN-BD11 cells to ninhydrin enables selection of robust toxin-resistant cells but with decreased gene expression of insulin secretory function. PANCREAS, 36 (3). pp. 294-301.

Taylor, Ashley, Irwin, Nigel, McKillop, Aine, Flatt, Peter and Gault, Victor (2008) Sub-chronic administration of the 11 beta-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity. BIOLOGICAL CHEMISTRY, 389 (4). pp. 441-445.

Cassidy, Roslyn S., Irwin, Nigel and Flatt, Peter (2008) Effects of gastric inhibitory polypeptide (GIP) and related analogues on glucagon release at normo- and hyperglycaemia in Wistar rats and isolated islets. BIOLOGICAL CHEMISTRY, 389 (2). pp. 189-193.

Abdel-Wahab, Yasser, Power, Gavin J., Ng, Ming T., Flatt, Peter and Conlon, J. Michael (2008) Insulin-releasing properties of the frog skin peptide pseudin-2 and its [Lys(18)]-substituted analogue. BIOLOGICAL CHEMISTRY, 389 (2). pp. 143-148.

Irwin, Nigel, Hunter, Kerry, Frizzell, Nonna and Flatt, Peter (2008) Antidiabetic effects of sub-chronic administration of the cannabinoid receptor (CB1) antagonist, AM251, in obese diabetic (ob/ob) mice. EUROPEAN JOURNAL OF PHARMACOLOGY, 581 (1-2). pp. 226-233.

McKillop, Aine, Duffy, Nicola A, Lindsay, John R, O'Harte, Finbarr, Bell, Patrick M and Flatt, Peter (2008) Decreased dipeptidyl peptidase-IV activity and glucagon-like peptide-1(7-36)amide degradation in type 2 diabetic subjects. DIABETES RESEARCH AND CLINICAL PRACTICE, 79 (1). pp. 79-85.

McKillop, Aine and Flatt, Peter (2008) Recent developments in the search for biomarkers for the diagnosis and monitoring of diabetes. Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, 2 (3). pp. 172-177.

Irwin, Nigel, Flatt, Peter and Gault, Victor (2008) GIP-based therapeutics for diabetes and obesity. Current Chemical Biology , 2. pp. 61-68.

Gault, Victor, Kerr, BD, Irwin, Nigel and Flatt, Peter (2008) Effects of C-terminal mini-PEGylation on metabolic stability and biological activity. Diabetic Medicine , 25 (S1). pp. 12-12.

Green, Brian D. and Flatt, Peter (2007) Incretin hormone mimetics and analogues in diabetes therapeutics. BEST PRACTICE AND RESEARCH CLINICAL ENDOCRINOLOGY AND METABOLISM, 21 (4). pp. 497-516.

McClean, Paula, Irwin, Nigel, Cassidy, Roslyn S., Holst, Jens J., Gault, Victor and Flatt, Peter (2007) GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 293 (6). pp. E1746-E1755.

Irwin, Nigel, Hunter, Kerry and Flatt, Peter (2007) Comparison of the metabolic effects of GIP receptor antagonism and PYY(3-36) receptor activation in high fat fed mice. PEPTIDES, 28 (11). pp. 2192-2198.

Kiely, Aoife, McClenaghan, Neville, Flatt, Peter and Newsholme, Philip (2007) Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic beta-cell line. JOURNAL OF ENDOCRINOLOGY, 195 (1). pp. 113-123.

Irwin, Nigel, McClean, Paula, Cassidy, Roslyn S, O'Harte, Finbarr, Green, Brian D, Gault, Victor, Harriott, Patrick and Flatt, Peter (2007) Comparison of the anti-diabetic effects of GIP- and GLP-1-receptor activation in obese diabetic (ob/ob) mice: studies with DPP IV resistant N-AcGIP and exendin(1-39)amide. DIABETES-METABOLISM RESEARCH AND REVIEWS, 23 (7). pp. 572-579.

Abdel-Wahab, Yasser, Clarke, G. C. and Flatt, Peter (2007) Acacia catechu aqueous bark extract stimulates insulin secretion and insulin action and inhibits starch digestion. DIABETOLOGIA, 50 (Suppl. 1). pp. 0915.

Gault, Victor, Taylor, AI, Irwin, Nigel, McKillop, Aine and Flatt, Peter (2007) Effects of 11 beta-hydroxysteroid dehydrogenase inhibition on body weight and glucose homeostasis in mice with diet-induced obesity. DIABETOLOGIA, 50 (Suppl. 1). pp. 0659.

Kiely, A. M., Flatt, Peter and Newsholme, P. (2007) Pro-inflammatory cytokines inhibit insulin secretion but increase glucose consumption, lactate production, triacylglycerol utilisation and AMPK activiation in a clonal pancreatic beta cell line. DIABETOLOGIA, 50 (Suppl. 1). pp. 0546.

O'Harte, Finbarr, Frizelle, PA and Flatt, Peter (2007) Enzyme resistant N-terminally modified cholecystokinin-8 exhibits enhanced satiety and insulinotrophism compared with exendin-4. DIABETOLOGIA, 50 (Suppl. 1). pp. 0585.

Brennan, L., Scullion, S. M., Mion, B., Hewage, C., Malthouse, J. P. G., Flatt, Peter, Newsholme, P. and McClenaghan, Neville H. (2007) Prolonged alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic beta cells. DIABETOLOGIA, 50 (Suppl. 1). pp. 0509.

McKillop, Aine, Duffy, NA, Green, BD, Irwin, Nigel, Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2007) Antidiabetic action of nateglinide includes augmentation of glucagon-like peptide-1 activity mediated partly through inhibition of DPP IV mediated degradation. DIABETOLOGIA, 50 (Suppl. 1). pp. 0882.

Liu, Hui-Kang, McCluskey, Janie, McClenaghan, Neville and Flatt, Peter (2007) Streptozotocin-resistant BRIN-BD11 cells possess wide spectrum of toxin tolerance and enhanced insulin-secretory capacity. ENDOCRINE, 32 (1). pp. 20-29.

Gault, Victor, McClean, Paula, Cassidy, R. S., Irwin, Nigel and Flatt, Peter (2007) Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets. DIABETOLOGIA, 50 (8). pp. 1752-1762.

Irwin, Nigel, McClean, Paula, O'Harte, Finbarr, Gault, Victor, Harriott, P and Flatt, Peter (2007) Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. DIABETOLOGIA, 50 (7). pp. 1532-1540.

Gault, Victor, McClean, Paula, Irwin, Nigel, Power, Gavin J., McCluskey, Janie and Flatt, Peter (2007) Effects of subchronic treatment with the long-acting glucose-dependent insulinotropic polypeptide receptor agonist, N-AcGIP, on glucose homeostasis in Streptozotocin-induced diabetes. PANCREAS, 35 (1). pp. 73-79.

Duffy, Nicola A, Green, Brian D, Irwin, Nigel, Gault, Victor, McKillop, Aine, O'Harte, Finbarr and Flatt, Peter (2007) Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: Nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1. EUROPEAN JOURNAL OF PHARMACOLOGY, 568 (1-3). pp. 278-286.

O'Harte, Finbarr, Hunter, Kerry, Gault, Victor, Irwin, Nigel, Green, Brian D., Greer, Brett, Harriott, Patrick, Bailey, Clifford J. and Flatt, Peter (2007) Antagonistic effects of two novel GIP analogs, (Hyp(3))GIP and (Hyp(3)) GIPLys(16)PAL, on the biological actions of GIP and longer-term effects in diabetic ob/ob mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 292 (6). pp. E1674-E1682.

Irwin, Nigel, McClean, Paula and Flatt, Peter (2007) Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic (ob/ob) mice. JOURNAL OF PEPTIDE SCIENCE, 13 (6). pp. 400-405.

Patterson, Steven, Flatt, Peter and McClenaghan, Neville (2007) Major metabolic homocysteine-derivative, homocysteine thiolactone, exerts changes in pancreatic beta-cell glucose-sensing, cellular signal transduction and integrity. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 461 (2). pp. 287-293.

Patterson, Steven, Scullion, Siobhan M. J., McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2007) Prolonged exposure to homocysteine results in diminished but reversible pancreatic beta-cell responsiveness to insulinotropic agents. DIABETES-METABOLISM RESEARCH AND REVIEWS, 23 (4). pp. 324-334.

Green, B. D., Irwin, Nigel and Flatt, Peter (2007) Direct and indirect effects of obestatin peptides on food intake and the regulation of glucose homeostasis and insulin secretion in mice. PEPTIDES, 28 (5). pp. 981-987.

Gault, Victor, Hunter, Kerry, Irwin, Nigel, Green, Brian D, Greer, Brett, Harriott, Patrick, O'Harte, Finbarr and Flatt, Peter (2007) Characterisation and biological activity of Glu(3) amino acid substituted GIP receptor antagonists. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 461 (2). pp. 263-274.

Irwin, Nigel, McClean, Paula, Harriott, Patrick and Flatt, Peter (2007) Beneficial effects of sub-chronic activation of glucagon-like peptide-1 (GLP-1) receptors on deterioration of glucose homeostasis and insulin secretion in aging mice. EXPERIMENTAL GERONTOLOGY, 42 (4). pp. 296-300.

Irwin, Nigel, Parker, JC, Gault, Victor, Greer, B, Harriott, P, O'Harte, Finbarr and Flatt, Peter (2007) N-terminally truncated metabolite of glucose-dependent insulinotropic polypeptide (GIP) but not glucagon-like peptide-1 (GLP-1) improves glucose homeostasis in ob/ob mice through alleviation of insulin resistance. DIABETIC MEDICINE, 24 (Suppl. 1). pp. 22.

O'Harte, Finbarr, Irwin, Nigel, Gault, Victor, McClean, Paula, Cassidy, RS, Harriott, P and Flatt, Peter (2007) Antidiabetic effects of sub-chronic administration of stable incretin mimetics N-AcGIP and exendin-4 (1-39) amide in obese-diabetic mice. DIABETIC MEDICINE, 24 (Suppl. 1). pp. 22.

Abdel-Wahab, Yasser, Mathews, J. N. and Flatt, Peter (2007) Momordica charantia (karela) aqueous seed extract stimulates insulin secretion and insulin action in vitro. DIABETIC MEDICINE, 24 (Suppl. 1). pp. 33.

Green, B. D., Irwin, Nigel and Flatt, Peter (2007) Direct and indirect effects of the anorectic hormone obestatin on glucose regulation and insulin secretion in mice. DIABETIC MEDICINE, 24 (Suppl. 1). pp. 41.

Paget, M. B., Murray, H. E., Bailey, C. J., Flatt, Peter and Downing, R. (2007) Insulin secretion from BRIN-BD11 cells in response to co-culture with endothelial cells and a thiazolidinedione. DIABETIC MEDICINE, 24 (Suppl. 1). pp. 32-33.

Hannan, J. M. A., Ali, L., Rokeya, B., Khaleque, J., Akhter, M., Flatt, Peter and Abdel-Wahab, Yasser (2007) Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action. BRITISH JOURNAL OF NUTRITION, 97 (3). pp. 514-521.

Gault, Victor, McClean, Paula, Irwin, Nigel, McCluskey, Janie and Flatt, Peter (2007) Effects of GIP-receptor antagonism in a streptozotocin-induced model of insulin deficiency. DIABETIC MEDICINE, 24 (Suppl. 1). pp. 40.

McClean, Paula, Gault, Victor, Irwin, Nigel, Power, G. J., McCluskey, Janie and Flatt, Peter (2007) Effects of daily administration of the glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, N-Acetyl-GIP, in streptozotocin-incluced diabetic mice. DIABETIC MEDICINE, 24 (Suppl. 1). pp. 40-41.

Parker, Jeremy C, Irwin, Nigel, Lavery, Kerry S, Green, Brian D, O'Harte, Finbarr, Gault, Victor and Flatt, Peter (2007) Metabolic effects of sub-chronic ablation of the incretin receptors by daily administration of (Pro(3))GIP and exendin(9-39)amide in obese diabetic (ob/ob) mice. BIOLOGICAL CHEMISTRY, 388 (2). pp. 221-226.

Gault, Victor, Hunter, Kerry, Irwin, Nigel, Greer, Brett, Green, Brian D, Harriott, Patrick, O'Harte, Finbarr and Flatt, Peter (2007) Characterisation and glucoregulatory actions of a novel acylated form of the (Pro(3))GIP receptor antagonist in type 2 diabetes. BIOLOGICAL CHEMISTRY, 388 (2). pp. 173-179.

Patterson, Steven, Flatt, Peter and McClenaghan, Neville (2007) Homocysteine-induced impairment of insulin secretion from clonal pancreatic BRIN-BD11 beta-cells is not prevented by catalase. PANCREAS, 34 (1). pp. 144-151.

Hannan, J. M. A., Ali, Lamin Marenah Liaquat, Rokeya, Begurn, Flatt, Peter and Abdel-Wahab, Yasser (2007) Insulin secretory actions of extracts of Asparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic beta-cells. JOURNAL OF ENDOCRINOLOGY, 192 (1). pp. 159-168.

Abdel-Wahab, Yasser, Marenah, Lamin, Flatt, Peter and Conlon, J. Michael (2007) Insulin releasing properties of the temporin family of antimicrobial peptides. PROTEIN AND PEPTIDE LETTERS, 14 (7). pp. 702-707.

Gault, Victor, Taylor, AI, Irwin, Nigel, McKillop, Aine and Flatt, Peter (2007) Metabolic effects of 11beta-hydroxysteroid dehydrogenase inhibition in an animal model of diet-induced obesity. Irish Journal of Medical Science , 176 (S9). pp. 382-382.

Mckillop, Aine, Duffy, Nicola, Lindsay, John, Green, Brian, O'Harte, Finbarr, Bell, Patrick and Flatt, Peter (2007) Effects of nateglinide on DPP-IV activity and incretin hormone degradation in type 2 diabetic patients. Irish Journal of Medical Science, 176. pp. S367.

Flatt, Peter and Green, B. D. (2006) Nutrient regulation of pancreatic beta-cell function in diabetes: problems and potential solutions. BIOCHEMICAL SOCIETY TRANSACTIONS, 34 (Part 5). pp. 774-778.

Brennan, Lorraine, Hewage, Chandralal, Malthouse, J. P. G., McClenaghan, Neville, Flatt, Peter and Newsholme, Philip (2006) Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism. FEBS JOURNAL, 273 (22). pp. 5160-5168.

Green, Brian D, Irwin, Nigel, Duffy, Nicola A, Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2006) Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1. EUROPEAN JOURNAL OF PHARMACOLOGY, 547 (1-3). pp. 192-199.

Parker, JC, Lavery, KS, Irwin, Nigel, Green, BD, Greer, B, Harriott, P, O'Harte, Finbarr, Gault, Victor and Flatt, Peter (2006) Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3-42) and GLP-1 (9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice. JOURNAL OF ENDOCRINOLOGY, 191 (1). pp. 93-100.

Conlon, J. Michael, Patterson, Steven and Flatt, Peter (2006) Major contributions of comparative endocrinology to the development and exploitation of the incretin concept. JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-COMPARATIVE EXPERIMENTAL BIOLOGY, 305A (9). pp. 781-786.

McClenaghan, Neville, Flatt, Peter and Ball, Andrew J. (2006) Actions of glucagon-like peptide-1 on K-ATP channel-dependent and -independent effects of glucose, sulphonylureas and nateglinide. JOURNAL OF ENDOCRINOLOGY, 190 (3). pp. 889-896.

Corless, Mary, Kiely, Aoife, McClenaghan, Neville, Flatt, Peter and Newsholme, Philip (2006) Glutamine regulates expression of key transcription factor, signal transduction, metabolic gene, and protein expression in a clonal pancreatic beta-cell line. JOURNAL OF ENDOCRINOLOGY, 190 (3). pp. 719-727.

Irwin, Nigel, Clarke, GC, Gault, Victor, Green, BD, Harriott, P, O'Harte, Finbarr and Flatt, Peter (2006) Long-acting analogues of GIP with significantly improved antihyperglycaemic and insulinotropic properties: N-terminal modification versus mid-chain acylation. DIABETOLOGIA, 49 (Suppl. 1). pp. 0172.

Green, Brian D., Irwin, Nigel, Cassidy, Roslyn S., Gault, Victor and Flatt, Peter (2006) Long-term administration of PACAP receptor antagonist, PACAP(6-27), impairs glucose tolerance and insulin sensitivity in obese diabetic ob/ob mice. PEPTIDES, 27 (9). pp. 2343-2349.

Irwin, Nigel, Clarke, Gillian C, Green, Brian D, Greer, Brett, Harriott, Patrick, Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2006) Evaluation of the antidiabetic activity of DPP IV resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide. BIOCHEMICAL PHARMACOLOGY, 72 (6). pp. 719-728.

Gault, Victor, Hunter, Kerry, Irwin, Nigel, Green, BD, O'Harte, Finbarr and Flatt, Peter (2006) Characterisation of novel glucose-dependent insulinotropic polypeptide (GIP) antagonists generated through amino acid substitution at position Glu(3). DIABETOLOGIA, 49 (Suppl. 1). pp. 0672.

McKillop, Aine, Duffy, NA, Lindsay, JR, Green, BD, O'Harte, Finbarr, Bell, PM and Flatt, Peter (2006) Insulinotropic actions of nateglinide are accompanied by inhibition of dipeptidyl peptidase-IV activity. DIABETOLOGIA, 49 (Suppl. 1). pp. 0796.

O'Harte, Finbarr, Hunter, K., Gault, Victor, Irwin, Nigel, Harriott, P. and Flatt, Peter (2006) Cellular and metabolic evaluation of (hydroxyproline(3))-GIP as new stable GIP receptor antagonist with antidiabetic potential. DIABETOLOGIA, 49 (Suppl. 1). pp. 0661.

Flatt, Peter, Irwin, Nigel, McClean, Paula, Green, BD, Gault, Victor, Bailey, CJ and O'Harte, Finbarr (2006) Early administration of the GIP receptor antagonist (Pro(3))GIP counters development of hyperglycaemia, glucose intolerance and insulin resistance in genetic obesity. DIABETOLOGIA, 49 (Suppl. 1). pp. 0171.

Green, Brian D, Lavery, Kerry S, Irwin, Nigel, O'Harte, Finbarr, Harriott, Patrick, Greer, Brett, Bailey, Clifford J and Flatt, Peter (2006) Novel glucagon-like peptide-1 (GLP-1) analog (Val(8))GLP-1 results in significant improvements of glucose tolerance and pancreatic beta-cell function after 3-week daily administration in obese diabetic (ob/ob) mice. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 318 (2). pp. 914-921.

Irwin, Nigel, Green, Brian D, Parker, Jeremy C, Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2006) Biological activity and antidiabetic potential of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide, GIP(1-16) and (Pro(3))GIP(1-16). REGULATORY PEPTIDES, 135 (1-2). pp. 45-53.

Patterson, Steven, Flatt, Peter and McClenaghan, Neville (2006) Homocysteine and other structurally-diverse amino thiols can alter pancreatic beta cell function without evoking cellular damage. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1760 (7). pp. 1109-1114.

Hannan, J. M. A., Ali, L., Khaleque, J., Akhter, M., Flatt, Peter and Abdel-Wahab, Yasser (2006) Aqueous extracts of husks of Plantago ovata reduce hyperglycaemia in type 1 and type 2 diabetes by inhibition of intestinal glucose absorption. BRITISH JOURNAL OF NUTRITION, 96 (1). pp. 131-137.

Marenah, Lamin, McCluskey, Janie, Abdel-Wahab, Yasser, O'Harte, Finbarr, McClenaghan, Neville and Flatt, Peter (2006) A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL(16)), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones. BIOLOGICAL CHEMISTRY, 387 (7). pp. 941-947.

Alana, I, Parker, JC, Gault, Victor, Flatt, Peter, O'Harte, Finbarr, Malthouse, JPG and Hewage, CM (2006) NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water. JOURNAL OF BIOLOGICAL CHEMISTRY, 281 (24). pp. 16370-16376.

Green, BD, Irwin, Nigel and Flatt, Peter (2006) Pituitary adenylate cyclase-activating peptide (PACAP): Assessment of dipeptidyl peptidase IV degradation, insulin-releasing activity and antidiabetic potential. PEPTIDES, 27 (6). pp. 1349-1358.

Graham, C, Richter, SC, McClean, Stephen, O'Kane, E, Flatt, Peter and Shaw, C (2006) Histamine-releasing and antimicrobial peptides from the skin secretions of the Dusky Gopher frog, Rana sevosa. PEPTIDES, 27 (6). pp. 1313-1319.

Patterson, Steven, Flatt, Peter, Brennan, L., Newsholme, P. and McClenaghan, Neville (2006) Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion. JOURNAL OF ENDOCRINOLOGY, 189 (2). pp. 301-310.

Hannan, JMA, Marenah, L, Ali, L, Rokeya, B, Flatt, Peter and Abdel-Wahab, Yasser (2006) Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic beta-cells. JOURNAL OF ENDOCRINOLOGY, 189 (1). pp. 127-136.

Irwin, Nigel, Green, BD, Gault, Victor, Cassidy, RS, O'Harte, Finbarr, Harriott, P and Flatt, Peter (2006) Effects on glucose homeostasis and insulin secretion of long term activation of the glucose-dependent insulinotropic polypeptide (GIP) receptor by N-AcGIP(LysPAL(37)) in normal mice. PEPTIDES, 27 (4). pp. 893-900.

Mathews, JN, Flatt, Peter and Abdel-Wahab, Yasser (2006) Asparagus adscendens (Shweta musali) stimulates insulin secretion, insulin action and inhibits starch digestion. BRITISH JOURNAL OF NUTRITION, 95 (3). pp. 576-581.

McKillop, Aine, Lindsay, JR, Au, S, Mahood, KI, O'Harte, Finbarr, Flatt, Peter and Bell, PM (2006) Meal-dependent regulation of circulating glycated insulin in type 2 diabetic subjects. HORMONE AND METABOLIC RESEARCH, 38 (2). pp. 94-97.

Irwin, Nigel, O'Harte, Finbarr, Gault, Victor, Green, BD, Greer, B, Harriott, P, Bailey, CJ and Flatt, Peter (2006) GIP(Lys(16)PAL) and GIP(LyS(37)PAL): Novel long-acting acylated analogues of glucose-dependent insulinotropic polypeptide with improved antidiabetic potential. JOURNAL OF MEDICINAL CHEMISTRY, 49 (3). pp. 1047-1054.

Irwin, Nigel, Green, BD, Gault, Victor, Harriot, P, O'Harte, Finbarr and Flatt, Peter (2006) Stable agonist of glucose-dependent insulinotropic polypeptide (GIP) restores pancreatic beta cell glucose responsiveness but not glucose intolerance in aging mice. EXPERIMENTAL GERONTOLOGY, 41 (2). pp. 151-156.

Liu, Hui-Kang, Green, Brian D., McClenaghan, Neville, McCluskey, Janie and Flatt, Peter (2006) Deleterious effects of supplementation with dehydroepiandrosterone sulphate or dexamethasone on rat insulin-secreting cells under in vitro culture condition. BIOSCIENCE REPORTS, 26 (1). pp. 31-38.

Marenah, L, Flatt, Peter, Orr, DF, Shaw, C and Abdel-Wahab, Yasser (2006) Skin secretions of Rana saharica frogs reveal antimicrobial peptides esculentins-1 and-1B and brevinins-1E and-2EC with novel insulin releasing activity. JOURNAL OF ENDOCRINOLOGY, 188 (1). pp. 1-9.

O'Harte, Finbarr, Irwin, Nigel, Green, BD, Gault, Victor, Cassidy, RS, Harriott, P and Flatt, Peter (2006) Administration of fatty acid linked glucose-dependent insulinotropic polypeptide receptor antagonist for two weeks improves glucose tolerance in normal mice. Diabetic Medicine , 23 (S2). pp. 22-22.

Gault, Victor, Irwin, Nigel, Green, BD, O'Harte, Finbarr and Flatt, Peter (2006) Long-acting glucose-dependent insulinotropic polypeptide (GIP) receptor agonist restores beta-cell glucose responsiveness in ageing mice. Diabetic Medicine , 23 (S2). pp. 31-31.

Irwin, Nigel, Gault, Victor, Green, BD, Greer, B, Harriott, P, Bailey, CJ, O'Harte, Finbarr and Flatt, Peter (2006) Novel long-acting acylated analogues of glucose-dependent insulinotropic polypeptide (GIP) with enhanced antihyperglycaemic and insulinotropic properties. Diabetic Medicine, 23 (S2). pp. 8-8.

Cunningham, GA, McClenaghan, Neville, Flatt, Peter and Newsholme, P (2005) L-alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic beta-cell line and protects from pro-inflammatory cytokine-induced apoptosis. CLINICAL SCIENCE, 109 (5). pp. 447-455.

Marenah, L, Flatt, Peter, Orr, DF, Shaw, C and Abdel-Wahab, Yasser (2005) Isolation and structural characterization of novel Rugosin A-like insulinotropic peptide from the skin secretions of Rana saharica frog. PEPTIDES, 26 (11). pp. 2117-2123.

Marenah, L, Flatt, Peter, Orr, DF, Shaw, C and Abdel-Wahab, Yasser (2005) Characterization of naturally occurring peptides in the skin secretion of Rana pipiens frog reveal pipinin-1 as the novel insulin-releasing agent. JOURNAL OF PEPTIDE RESEARCH, 66 (4). pp. 204-210.

Green, BD, Liu, HK, McCluskey, Janie, Duffy, NA, O'Harte, Finbarr, McClenaghan, Neville and Flatt, Peter (2005) Function of a long-term, GLP-1-treated, insulin-secreting cell line is improved by preventing DPP IV-mediated degradation of GLP-1. DIABETES OBESITY AND METABOLISM, 7 (5). pp. 563-569.

Irwin, Nigel, Green, BD, Mooney, MH, Greer, B, Harriott, P, Bailey, CJ, Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2005) A novel, long-acting agonist of glucose-dependent insulinotropic polypeptide suitable for once-daily administration in type 2 diabetes. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 314 (3). pp. 1187-1194.

Green, BD, Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2005) A comparison of the cellular and biological properties of DPP-IV-resistant N-glucitol analogues of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. DIABETES OBESITY AND METABOLISM, 7 (5). pp. 595-604.

Gault, Victor, Irwin, Nigel, Green, BD, McCluskey, Janie, Greer, B, Bailey, CJ, Harriott, P, O'Harte, Finbarr and Flatt, Peter (2005) Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro(3))GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes. DIABETES, 54 (8). pp. 2436-2446.

Irwin, Nigel, Gault, Victor, Green, BD, Greer, B, Harriott, P, Bailey, CJ, O'Harte, Finbarr and Flatt, Peter (2005) Antidiabetic potential of two novel fatty acid derivatised, N-terminally modified analogues of glucose-dependent insulinotropic polypeptide (GIP): N-AcGIP(LysPAL(16)) and N-AcGIP(LysPAL(37)). BIOLOGICAL CHEMISTRY, 386 (7). pp. 679-687.

Abdel-Wahab, Yasser, Marenah, L, Orr, DF, Shaw, C and Flatt, Peter (2005) Isolation and structural characterisation of a novel 13-amino acid insulin-releasing peptide from the skin secretion of Agalychnis calcarifer. BIOLOGICAL CHEMISTRY, 386 (6). pp. 581-587.

Graham, C, Irvine, A. E., McClean, Stephen, Richter, S. C., Flatt, Peter and Shaw, C. (2005) Peptide Tyrosine Arginine, a potent immunomodulatory peptide isolated and structurally characterized from the skin secretions of the dusky gopher frog, Rana sevosa. Peptides, 26 (5). pp. 737-743.

Green, BD, Irwin, Nigel, Gault, Victor, Bailey, CJ, O'Harte, Finbarr and Flatt, Peter (2005) Chronic treatment with exendin(9-39)amide indicates a minor role for endogenous glucagon-like peptide-1 in metabolic abnormalities of obesity-related diabetes in ob/ob mice. JOURNAL OF ENDOCRINOLOGY, 185 (2). pp. 307-317.

Lindsay, JR, Duffy, NA, McKillop, Aine, Ardill, J, O'Harte, Finbarr, Flatt, Peter and Bell, PM (2005) Inhibition of dipeptidyl peptidase IV activity by oral metformin in Type 2 diabetes. DIABETIC MEDICINE, 22 (5). pp. 654-657.

Irwin, Nigel, Green, BD, Gault, Victor, Greer, B, Harriott, P, Bailey, CJ, Flatt, Peter and O'Harte, Finbarr (2005) Degradation, insulin secretion, and antihyperglycemic actions of two palmitate-derivitized N-terminal pyroglutamyl analogues of glucose-dependent insulinotropic polypeptide. JOURNAL OF MEDICINAL CHEMISTRY, 48 (4). pp. 1244-1250.

Ball, AJ, Flatt, Peter and McClenaghan, Neville (2005) Alterations of insulin secretion following long-term manipulation of ATP-sensitive potassium channels by diazoxide and nateglinide. BIOCHEMICAL PHARMACOLOGY, 69 (1). pp. 59-63.

Brennan, L, Hewage, C, Malthouse, JG, McClenaghan, Neville, Flatt, Peter and Newsholme, P (2005) Effects of anti-diabetic drugs on beta cell glucose metabolism in a clonal cell line, BRIN-BD11. DIABETOLOGIA, 48 (Suppl. 1). pp. 439.

Hannan, JMA, Abdel-Wahab, Yasser, Marenah, L, Khaleque, J, Akhter, M, Ali, L and Flatt, Peter (2005) Mechanism of insulin secretory effects of traditional antidiabetic plant extract PE027. DIABETOLOGIA, 48 (Suppl. 1). pp. 762.

Green, Brian, Irwin, Nigel, Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2005) Development and therapeutic potential of incretin hormone analogues for type 2 diabetes. The British Journal of Diabetes and Vascular Disease , 5. pp. 134-140.

Lavery, KS, Green, BD, Parker, JC, Irwin, Nigel, Gault, Victor, Flatt, Peter and O'Harte, Finbarr (2005) The truncated peptide glucagon-like peptide-1(9-36)amide has no insulin releasing activity but retains a significant effect on glucose disposal in vitro and in vivo. Diabetic Medicine, 22 (S2). pp. 17-17.

O'Harte, Finbarr, Irwin, Nigel, Green, BD, Harriott, P, Greer, B, Gault, Victor and Flatt, Peter (2005) Once daily administration of (Pro3)GIP ameliorates glucose intolerance and improves insulin sensitivity in obese diabetic (ob/ob) mice.. Irish Journal of Medical , 174 (S2). pp. 8-8.

Furman, B, Pyne, N, Flatt, Peter and O'Harte, Finbarr (2004) Targeting beta-cell cyclic 3 ` 5 ` adenosine monophosphate for the development of novel drugs for treating type 2 diabetes mellitus. A review. JOURNAL OF PHARMACY AND PHARMACOLOGY, 56 (12). pp. 1477-1492.

Irwin, Nigel, Gault, Victor, Green, BD, Greer, B, McCluskey, Janie, Harriott, P, O'Harte, Finbarr and Flatt, Peter (2004) Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice. BIOLOGICAL CHEMISTRY, 385 (9). pp. 845-852.

Gault, Victor, Irwin, Nigel, O'Harte, Finbarr, Green, BD and Flatt, Peter (2004) Antidiabetic potential of a long-acting derivative of GIP following once daily administration in type 2 diabetes. REGULATORY PEPTIDES, 122 (1). pp. A55.

O'Harte, Finbarr, Irwin, Nigel, Gault, Victor, Green, BD and Flatt, Peter (2004) Assessment of the antidiabetic potential of two fatty acid derivatized GIP analogues. REGULATORY PEPTIDES, 122 (1). pp. A105.

Green, BD, Gault, Victor, Flatt, Peter, Harriott, P, Greer, B and O'Harte, Finbarr (2004) Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala(8)/Ala(2) with 2-aminobutyric acid. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 428 (2). pp. 136-143.

Marenah, L, McClean, Stephen, Flatt, Peter, Orr, DF, Shaw, C and Abdel-Wahab, Yasser (2004) Novel insulin-releasing peptides in the skin of Phyllomedusa trinitatis frog include 28 amino acid peptide from dermaseptin BIV precursor. PANCREAS, 29 (2). pp. 110-115.

McClenaghan, Neville, McCluskey, Janie, Flatt, Peter and Patterson, Steven (2004) Homocysteine, a metabolic syndrome risk factor, exerts detrimental effects on insulin secretion and pancreatic beta cell function. DIABETOLOGIA, 47 (Suppl. 1). pp. 466.

Abdel-Wahab, Yasser, Marenah, L, Orr, DF, Shaw, C and Flatt, Peter (2004) Isolation and structural characterisation of a novel 13 amino acid insulin-releasing peptide from the skin secretion of Agalychnis calcarifer. DIABETOLOGIA, 47 (Suppl. 1). pp. 12.

Marenah, L, Shaw, C, Orr, DF, McClean, Stephen, Flatt, Peter and Abdel-Wahab, Yasser (2004) Isolation and characterisation of an unexpected class of insulinotropic peptides in the skin of the frog Agalychnis litodryas. REGULATORY PEPTIDES, 120 (1-3). pp. 33-38.

McKillop, Aine, Duffy, N, Lindsay, JR, Flatt, Peter, Bell, PM and O'Harte, Finbarr (2004) Decreased dipeptidyl peptidase-IV activity and degradation of glucagon-like peptide-1(7-36)amide in Type 2 diabetes. DIABETOLOGIA, 47 (Suppl. 1). pp. 792.

Irwin, Nigel, Gault, Victor, Green, BD, Harriott, P, O'Harte, Finbarr and Flatt, Peter (2004) Long-acting Tyr(1)-modified analogues of GIP with significantly improved antihyperglycaemic and insulinotropic properties. DIABETOLOGIA, 47 (Suppl. 1). pp. 109.

Green, BD, Irwin, Nigel, Gault, Victor, O'Harte, Finbarr, Bailey, CJ and Flatt, Peter (2004) Chronic treatment of obese hyperglycaemic ob/ob mice with exendin(9-39)amide suggests a minor role for endogenous GLP-1 in metabolic abnormalities of obesity-diabetes. DIABETOLOGIA, 47 (Suppl. 1). pp. 659.

Miguel, JC, Patterson, Steven, Abdel-Wahab, Yasser, Mathias, PCF and Flatt, Peter (2004) Time-correlation between membrane depolarization and intracellular calcium in insulin secreting BRIN-BD11 cells: studies using FLIPR. CELL CALCIUM, 36 (1). pp. 43-50.

Ball, AJ, McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2004) Chronic exposure to tolbutamide and glibenclamide impairs insulin secretion but not transcription of K-ATP channel components. PHARMACOLOGICAL RESEARCH, 50 (1). pp. 41-46.

Ball, AJ, Flatt, Peter and McClenaghan, Neville (2004) Acute and long-term effects of nateglinide on insulin secretory pathways. BRITISH JOURNAL OF PHARMACOLOGY, 142 (2). pp. 367-373.

Marenah, L., Flatt, Peter, Orr, D. F., McClean, Stephen, Shaw, C. and Abdel-Wahab, Yasser (2004) Brevinin-1 and multiple insulin-releasing peptides in the skin of the frog Rana palustris. Journal of Endocrinology, 181 (2). pp. 347-354.

Liu, HK, Green, BD, McClenaghan, Neville, McCluskey, Janie and Flatt, Peter (2004) Long-term beneficial effects of vanadate, tungstate, and molybdate on insulin secretion and function of cultured beta cells. PANCREAS, 28 (4). pp. 364-368.

Lees Murdock, Diane, Clarke, J, Flatt, Peter, Barnett, YA and Barnett, CR (2004) Role of CYP2E1 in ketone-stimulated insulin release in pancreatic B-cells. BIOCHEMICAL PHARMACOLOGY, 67 (5). pp. 875-884.

Green, BD, Mooney, MH, Gault, Victor, Irwin, Nigel, Bailey, CJ, Harriott, P, Greer, B, O'Harte, Finbarr and Flatt, Peter (2004) N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity. JOURNAL OF ENDOCRINOLOGY, 180 (3). pp. 379-388.

Marenah, L, Flatt, Peter, Orr, DF, McClean, Stephen, Shaw, C and Abdel-Wahab, Yasser (2004) Skin secretion of the toad Bombina variegata contains multiple insulin-releasing peptides including bombesin and entirely novel insulinotropic structures. BIOLOGICAL CHEMISTRY, 385 (3-4). pp. 315-321.

Dixon, G, Nolan, J, McClenaghan, Neville, Flatt, Peter and Newsholme, P (2004) Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity. CLINICAL SCIENCE, 106 (2). pp. 191-199.

Green, BD, Mooney, MH, Gault, Victor, Irwin, Nigel, Bailey, CJ, Harriott, P, Greer, B, Flatt, Peter and O'Harte, Finbarr (2004) Lys(9) for Glu(9) substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9-36)amide and exendin (9-39). METABOLISM-CLINICAL AND EXPERIMENTAL, 53 (2). pp. 252-259.

Green, BD, Gault, Victor, Mooney, MH, Irwin, Nigel, Harriott, P, Greer, B, Bailey, CJ, O'Harte, Finbarr and Flatt, Peter (2004) Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala(8)-substituted GLP-1 analogues. BIOLOGICAL CHEMISTRY, 385 (2). pp. 169-177.

Liu, HK, Green, BD, Gault, Victor, McCluskey, Janie, McClenaghan, Neville, O'Harte, Finbarr and Flatt, Peter (2004) N-acetyl-GLP-1: a DPP IV-resistant analogue of glucagon-like peptide-1 (GLP-1) with improved effects on pancreatic beta-cell-associated gene expression. CELL BIOLOGY INTERNATIONAL, 28 (1). pp. 69-73.

Green, BD, Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2004) Structurally modified analogues of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypcptide (GIP) as future antidiabetic agents. CURRENT PHARMACEUTICAL DESIGN, 10 (29). pp. 3651-3662.

Liu, HK, Green, BD, Flatt, Peter, McClenaghan, Neville and McCluskey, Janie (2004) Effects of long-term exposure to nicotinamide and sodium butyrate on growth, viability, and the function of clonal insulin secreting cells. ENDOCRINE RESEARCH, 30 (1). pp. 61-68.

O'Harte, Finbarr, Green, BD, Gault, Victor, Irwin, Nigel, Mooney, MH, Harriott, P, Greer, B and Flatt, Peter (2004) (Lys9)GLP-1 lacks insulinotropic activity but acts as a potent novel GLP-1 receptor antagonist in vivo. Diabetic Medicine, 21 (S2). pp. 43-43.

Gault, Victor, Green, BD, Irwin, Nigel, Harriott, P, Greer, B, Flatt, Peter and O'Harte, Finbarr (2004) Development and characterisation of novel N-terminal Glu9-substituted agonists of glucagon-like peptide-1 (GLP-1). Diabetic Medicine, 21 (S2). pp. 26-26.

Flatt, Peter, Irwin, Nigel, Green, BD, Harriott, P, Gault, Victor and O'Harte, Finbarr (2004) Daily administration of GIP receptor antagonist alleviates glucose intolerance and counters insulin resistance in an animal model of obesity and type 2 diabetes. Diabetologia, 47 (S1). pp. 282-282.

McCluskey, Janie, Irwin, Nigel, Gault, Victor, Green, BD, Flatt, Peter and O'Harte, Finbarr (2004) Longer-term ablation of GIP signalling in normal mice demonstrates importance of GIP for glucose homeostasis as part of the enteroinsular axis. Proceedings of the EASD Islet Study Group, Meeting on Molecular Aspects of Pancreatic Islet Function, 1. pp. 26-26.

O'Harte, Finbarr, Irwin, Nigel, Gault, Victor, Green, BD and Flatt, Peter (2004) C-16 fatty acid derivatised GIP analogues as potential agents for diabetes therapy. Irish Journal of Medical Science, 173 (S1). pp. 10-10.

Hunter, Kerry, Irwin, Nigel, Green, BD, Flatt, Peter, O'Harte, Finbarr and Gault, Victor (2004) Novel long-acting enzyme-resistant glucose-dependent insulinotropic polypeptide receptor agonists with improved antihyperglycaemic and insulinotropic activity. Irish Journal of Medical Science, 173 (S1). pp. 35-35.

Green, BD, Gault, Victor, Mooney, MH, Irwin, Nigel, Harriott, P, Greer, B, O'Harte, Finbarr and Flatt, Peter (2004) Molecular, cellular and biological characteristics of DPP IV-resistant acetylated analogues of GLP-1. . Diabetic Medicine, 21 (S2). pp. 26-26.

Mckillop, Aine, Lindsay, John, O'Harte, Finbarr, Bell, Patrick and Flatt, Peter (2004) Meal and glucose-dependent insulinotropic polypeptide regulation of circulating glycated insulin in type 2 diabetic subjects. . Diabetic Medicine, 21. pp. 6-7.

Dixon, G, Nolan, J, McClenaghan, Neville, Flatt, Peter and Newsholme, P (2003) A comparative study of amino acid consumption by rat islet cells and the clonal beta-cell line BRIN-BD11 - the functional significance of L-alanine. JOURNAL OF ENDOCRINOLOGY, 179 (3). pp. 447-454.

Green, BD, Gault, Victor, Irwin, Nigel, Mooney, MH, Bailey, CJ, Harriott, P, Greer, B, Flatt, Peter and O'Harte, Finbarr (2003) Metabolic stability, receptor binding, cAMP generation, insulin secretion and antihyperglycaemic activity of novel N-terminal Glu(9)-substituted analogues of glucagon-like peptide-1. BIOLOGICAL CHEMISTRY, 384 (12). pp. 1543-1551.

Green, BD, Gault, Victor, Mooney, MH, Irwin, Nigel, Bailey, CJ, Harriott, P, Greer, B, Flatt, Peter and O'Harte, Finbarr (2003) Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo. JOURNAL OF MOLECULAR ENDOCRINOLOGY, 31 (3). pp. 529-540.

Brennan, L, Corless, M, Hewage, C, Malthouse, JPG, McClenaghan, Neville, Flatt, Peter and Newsholme, P (2003) C-13 NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line. DIABETOLOGIA, 46 (11). pp. 1512-1521.

Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2003) Glucose-dependent insulinotropic polypeptide (GIP): anti-diabetic and anti-obesity potential?. NEUROPEPTIDES, 37 (5). pp. 253-263.

Lindsay, JR, McKillop, Aine, Mooney, MH, O'Harte, Finbarr, Flatt, Peter and Bell, PM (2003) Effects of nateglinide on the secretion of glycated insulin and glucose tolerance in type 2 diabetes. DIABETES RESEARCH AND CLINICAL PRACTICE, 61 (3). pp. 167-173.

Gault, Victor, Flatt, Peter and O'Harte, Finbarr (2003) Glucose-dependent insulinotropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 308 (2). pp. 207-213.

Gault, Victor, O'Harte, Finbarr, Harriott, P and Flatt, Peter (2003) Degradation, cyclic adenosine monophosphate production, insulin secretion, and glycemic effects of two novel N-terminal Ala(2)-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo. METABOLISM-CLINICAL AND EXPERIMENTAL, 52 (6). pp. 679-687.

McKillop, Aine, Meade, A, Flatt, Peter and O'Harte, Finbarr (2003) Evaluation of the site(s) of glycation in human proinsulin by ion-trap LCQ electrospray ionization mass spectrometry. REGULATORY PEPTIDES, 113 (1-3). pp. 1-8.

Lindsay, JR, McKillop, Aine, Mooney, MH, Flatt, Peter, Bell, PM and O'Harte, Finbarr (2003) Meal-induced 24-hour profile of circulating glycated insulin in type 2 diabetic subjects measured by a novel radioimmunoassay. METABOLISM-CLINICAL AND EXPERIMENTAL, 52 (5). pp. 631-635.

Lindsay, JR, McKillop, Aine, Mooney, MH, O'Harte, Finbarr, Bell, PM and Flatt, Peter (2003) Demonstration of increased concentrations of circulating glycated insulin in human Type 2 diabetes using a novel and specific radioimmunoassay. DIABETOLOGIA, 46 (4). pp. 475-478.

Gallagher, Alison, Flatt, Peter, Duffy, G and Abdel-Wahab, Yasser (2003) The effects of traditional antidiabetic plants on in vitro glucose diffusion. NUTRITION RESEARCH, 23 (3). pp. 413-424.

Hunter, SJ, Boyd, AC, O'Harte, Finbarr, McKillop, Aine, Wiggam, MI, Mooney, MH, McCluskey, Janie, Lindsay, JR, Ennis, CN, Gamble, R, Sheridan, B, Barnett, CR, McNulty, Helene, Bell, PM and Flatt, Peter (2003) Demonstration of glycated insulin in human diabetic plasma and decreased biological activity assessed by euglycemic-hyperinsulinemic clamp technique in humans. DIABETES, 52 (2). pp. 492-498.

Gault, Victor, O'Harte, Finbarr, Harriott, P, Mooney, MH, Green, BD and Flatt, Peter (2003) Effects of the novel (Pro(3))GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin. DIABETOLOGIA, 46 (2). pp. 222-230.

Gault, Victor, Flatt, Peter, Harriott, P, Mooney, MH, Bailey, CJ and O'Harte, Finbarr (2003) Improved biological activity of Gly(2)- and Ser(2)-substituted analogues of glucose-dependent insulinotrophic polypeptide. JOURNAL OF ENDOCRINOLOGY, 176 (1). pp. 133-141.

Miguel, JC, Abdel-Wahab, Yasser, Green, BD, Mathias, PCF and Flatt, Peter (2003) Cooperative enhancement of insulinotropic action of GLP-1 by acetylcholine uncovers paradoxical inhibitory effect of beta cell muscarinic receptor activation on adenylate cyclase activity. BIOCHEMICAL PHARMACOLOGY, 65 (2). pp. 283-292.

Gault, Victor, Irwin, Nigel, Harriott, P, Flatt, Peter and O'Harte, Finbarr (2003) DPP IV resistance and insulin releasing activity of a novel di-substituted analogue of glucose-dependent insulinotropic polypeptide, (Ser(2)-Asp(13))GIP. CELL BIOLOGY INTERNATIONAL, 27 (1). pp. 41-46.

O'Harte, Finbarr, Gault, Victor, Harriott, P, Irwin, Nigel, Mooney, MH and Flatt, Peter (2003) Biological activity of two novel N-terminal Ala2-substituted analogues of glucose-dependent insulinotropic polypeptide. Diabetic Medicine, 20 (S2). pp. 35-35.

Irwin, Nigel, Gault, Victor, Flatt, Peter, Mooney, MH and O'Harte, Finbarr (2003) Biological activity of mono- and di-substituted analogues of gastric inhibitory polypeptide (GIP). Proceedings of BioNet Annual Conference, 1. pp. 28-28.

Green, BD, Gault, Victor, Monney, MH, Irwin, Nigel, Harriott, P, Greer, B, O'Harte, Finbarr and Flatt, Peter (2003) Dipeptidylpeptidase IV degradation, receptor binding, insulin-secreting and antihyperglycaemic characteristics of palmitate-derivitised glucagon-like peptide-1(7-36)amide analogues. Irish Journal of Medical Science, 172 (S1). pp. 41-41.

O'Harte, Finbarr, Green, BD, Mooney, MH, Gault, Victor, Irwin, Nigel, Harriott, P, Greer, B and Flatt, Peter (2003) Comparison of the activity of the novel dipeptidylpeptidase IV-resistant GLP-1 receptor antagonist (Lys9)GLP-1 with GLP-1(9-36)amide and exendin-4(9-39). Irish Journal of Medical Science, 172 (S1). pp. 10-10.

Irwin, Nigel, Green, BD, Lui, HK, McCluskey, Janie, McClenaghan, Neville, Gault, Victor, Harriott, P, Greer, B, O'Harte, Finbarr and Flatt, Peter (2003) Dipeptidylpeptidase IV-resistant glucagon-like peptide-1(7-36)amide analogue N-acetyl-GLP-1 has improved effects on pancreatic beta-cell associated gene expression. Irish Journal of Medical Science, 172 (S1). pp. 24-24.

Gault, Victor, Parker, JC, Harriott, P, Mooney, MH, Flatt, Peter and O'Harte, Finbarr (2003) Major metabolite of glucose-dependent insulinotropic polypeptide (GIP), GIP(3-42), acts as a GIP receptor antagonist in vivo. . Diabetic Medicine, 20 (S2). pp. 36-36.

Mooney, MH, Gault, Victor, Harriott, P, Flatt, Peter and O'Harte, Finbarr (2003) Fragment peptides reveal bioactive domains critical for insulin-releasing activity of glucose-dependent insulinotropic polypeptide. Diabetic Medicine, 20 (S2). pp. 35-35.

Green, BD, Gault, Victor, Harriott, P, Greer, B, Mooney, MH, Flatt, Peter and O'Harte, Finbarr (2003) Stability, cAMP production, insulin secretion and antihyperglycaemic activity of Pro3-substituted analogues of GLP-1 and GIP. Diabetic Medicine, 20 (S2). pp. 36-36.

Lindsay, John, Duffy, Nicola, Mckillop, Aine, Ardill, Joy, O'Harte, Finbarr, Flatt, Peter and Bell, Patrick (2003) Inhibition of dipeptidyl peptidase IV (DPP-IV) activity by oral metformin in type 2 diabetes. Diabetic Medicine, 20. pp. 4-5.

Mckillop, Aine, Duffy, Nicola, Lindsay, John, O'Harte, Finbarr and Flatt, Peter (2003) Decreased activity of dipeptidyl peptidase-IV potentially enhances glucagon-like peptide-1(7-36)amide and gastric inhibitory polypeptide. . Diabetic Medicine, 20. pp. 37.

Gault, Victor, Harriott, P, Flatt, Peter and O'Harte, Finbarr (2002) Cyclic AMP production and insulin releasing activity of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide. BIOSCIENCE REPORTS, 22 (5-6). pp. 523-528.

Picton, SF, McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2002) Effects of cytotoxic agents on functional integrity and antioxidant enzymes in clonal beta-cells. DIABETES AND METABOLISM, 28 (6, Part 2). pp. S70-S77.

McKillop, Aine, Abdel-Wahab, Yasser, Mooney, MH, O'Harte, Finbarr and Flatt, Peter (2002) Secretion of glycated insulin from pancreatic beta-cells in diabetes represents a novel aspect of beta-cell dysfunction and glucose toxicity. DIABETES AND METABOLISM, 28 (6, Part 2). pp. S61-S69.

Gault, Victor, Flatt, Peter, Bailey, CJ, Harriott, P, Greer, B, Mooney, MH and O'Harte, Finbarr (2002) Enhanced cAMP generation and insulin-releasing potency of two novel Tyr(1)-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes. BIOCHEMICAL JOURNAL, 367 (Part 3). pp. 913-920.

Gault, Victor, Parker, JC, Harriott, P, Flatt, Peter and O'Harte, Finbarr (2002) Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo. JOURNAL OF ENDOCRINOLOGY, 175 (2). pp. 525-533.

O'Harte, Finbarr, Gault, Victor, Parker, JC, Harriott, P, Mooney, MH, Bailey, CJ and Flatt, Peter (2002) Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP. DIABETOLOGIA, 45 (9). pp. 1281-1291.

McKillop, Aine, Lindsay, JR, Mooney, MH, O'Harte, Finbarr, Bell, PM and Flatt, Peter (2002) Electrospray ionization mass spectrometry characterisation and measurement of circulating glycated insulin and responses to fasting and feeding in Type 2 diabetic subjects. DIABETOLOGIA, 45 (Suppl. 2). pp. 1221.

Abdel-Wahab, Yasser, Marenah, L, Shaw, C and Flatt, Peter (2002) Isolation and structural characterisation of novel insulinotropic peptides from the skin secretion of Rana Pipiens. DIABETOLOGIA, 45 (Suppl. 2). pp. 549.

Mooney, MH, Gault, Victor, Flatt, Peter, Harriott, P, Greer, B, Bailey, CJ and O'Harte, Finbarr (2002) Antidiabetic potential of four novel analogues of glucose-dependent insulinotropic polypeptide demonstrated in an animal model of Type 2 diabetes. DIABETOLOGIA, 45 (Suppl. 2). pp. 547.

Gault, Victor, Green, BD, Greer, B, Harriott, P, Flatt, Peter and O'Harte, Finbarr (2002) N-terminally modified analogues of glucose-dependent insulinotropic polypeptide exhibit improved insulinotropic activity and antihyperglycaemic potential compared with glucagon-like peptide-1 counterparts. DIABETOLOGIA, 45 (Suppl. 2). pp. 545.

Green, BD, O'Harte, Finbarr, Greer, B, Harriott, P and Flatt, Peter (2002) Enhanced plasma stability, receptor binding, cyclic-amp production and insulin-releasing activity of two novel penultimate N-termnially substituted analogues of glucagon-like peptide-1. DIABETOLOGIA, 45 (Suppl. 2). pp. 486.

O'Harte, Finbarr, Gault, Victor, Harriott, P, Green, BD and Flatt, Peter (2002) Comparative studies with exendin(9-39)amide and the novel (Pro(3))GIP receptor antagonist indicates that glucose-dependent insulinotropic polypeptide is the major hormone of the enteroinsular axis. DIABETOLOGIA, 45 (Suppl. 2). pp. 548.

Flatt, Peter, Gault, Victor, Harriott, P, Greer, B, Mooney, MH, Bailey, CJ and O'Harte, Finbarr (2002) Novel N-Fmoc and N-palmitate analogues of glucose-dependent insullinotropic polypeptide exhibit DPP IV resistance, increased insulin-releasing activity and antidiabetic action.. DIABETOLOGIA, 45 (Suppl. 2). pp. 546.

Brennan, L, Shine, A, Hewage, C, Malthouse, JPG, Brindle, KM, McClenaghan, Neville, Flatt, Peter and Newsholme, P (2002) A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line - Metabolism of L-alanine is important to the regulation of insulin secretion. DIABETES, 51 (6). pp. 1714-1721.

Lindsay, JR, Au, STB, Kelly, CM, O'Harte, Finbarr, Flatt, Peter and Bell, PM (2002) A novel amino-terminally glycated analogue of glucose-dependent insulinotropic polypeptide (GIP), with prolonged insulinotropic activity in type 2 diabetes mellitus. DIABETES, 51 (Suppl. 2). pp. 1394.

Conroy, SJ, Green, I, Dixon, G, Byrne, PM, Nolan, J, Abdel-Wahab, Yasser, McClenaghan, Neville, Flatt, Peter and Newsholme, P (2002) Evidence for a sustained increase in clonal beta-cell basal intracellular Ca2+ levels after incubation in the presence of newly diagnosed type-1 diabetic patient sera. Possible role in serum-induced inhibition of insulin secretion. JOURNAL OF ENDOCRINOLOGY, 173 (1). pp. 53-62.

Abdel-Wahab, Yasser, O'Harte, Finbarr, Mooney, MH, Barnett, CR and Flatt, Peter (2002) Vitamin C supplementation decreases insulin glycation and improves glucose homeostasis in obese hyperglycemic (ob/ob) mice. METABOLISM-CLINICAL AND EXPERIMENTAL, 51 (4). pp. 514-517.

Gault, Victor, O'Harte, Finbarr, Harriott, P and Flatt, Peter (2002) Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 290 (5). pp. 1420-1426.

Van Eylen, F, Horta, OD, Barez, A, Kamagate, A, Flatt, Peter, Macianskiene, R, Mubagwa, K and Herchuelz, A (2002) Overexpression of the Na/Ca. exchanger shapes stimulus-induced cytosolic Ca2+ oscillations in insulin-producing BRIN-BD11 cells. DIABETES, 51 (2). pp. 366-375.

Miguel, JC, Abdel-Wahab, Yasser, Mathias, PCF and Flatt, Peter (2002) Muscarinic receptor subtypes mediate stimulatory and paradoxical inhibitory effects on an insulin-secreting beta cell line. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1569 (1-3). pp. 45-50.

Mooney, MH, Abdel-Wahab, Yasser, McKillop, Aine, O'Harte, Finbarr and Flatt, Peter (2002) Evaluation of glycated glucagon-like peptide-1(7-36)amide in intestinal tissue of normal and diabetic animal models. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1569 (1-3). pp. 75-80.

Hamid, M, McCluskey, Janie, McClenaghan, Neville and Flatt, Peter (2002) Comparison of the secretory properties of four insulin-secreting cell lines. ENDOCRINE RESEARCH, 28 (1-2). pp. 35-47.

Mooney, MH, Gault, Victor, Flatt, Peter, Harriott, P and O'Harte, Finbarr (2002) N-terminally modified degradation resistant analogues of glucose-dependent insulinotropic polypeptide display enhanced antidiabetic action.. Irish Journal of Medical Science, 171 (S3). pp. 9-9.

O'Harte, Finbarr, Gault, Victor, Harriott, H, Green, BD and Flatt, Peter (2002) Receptor antagonist studies indicate that GIP is a more important enteroinsular axis hormone than GLP-1 in obese diabetic (ob/ob) mice. Irish Journal of Medical Science, 171 (S3). pp. 18-18.

Lindsay, John, Duffy, Nicola, Mckillop, Aine, Ardill, Joy, O'Harte, Finbarr, Flatt, Peter and Bell, Patrick (2002) Metformin inhibits dipeptidyl peptidase IV activity in type 2 diabetes. Irish Journal of Medical Science, 171. pp. 29.

Mckillop, Aine, Lindsay, John, Mooney, Mark, Flatt, Peter, Bell, John and O'Harte, Finbarr (2002) Detection, isolation and fluctuation of glycated insulin in type 2 diabetic subjects. Irish Journal of Medical Science, 171. pp. 31.

Lindsay, John, Mckillop, Aine, Mooney, Mark, O'Harte, Finbarr, Flatt, Peter and Bell, Patrick (2002) Demonstration of diurnal variation of plasma glycated insulin in type 2 diabetes.. Endocrine Abstracts, 3. pp. 85.

Lindsay, John, Mckillop, Aine, Mooney, Mark, O'Harte, Finbarr, Bell, Patrick and Flatt, Peter (2002) Elevated plasma glycated insulin in type 2 diabetes, detected using a novel radioimmunoassay.. Diabetic Medicine, 19. pp. 182.

Mooney, MH, Abdel-Wahab, Yasser, Morgan, LM, O'Harte, Finbarr and Flatt, Peter (2001) Detection of glycated gastric inhibitory polypeptide within the intestines of diabetic obese (ob/ob) mice. ENDOCRINE, 16 (3). pp. 167-171.

McKillop, Aine, Mooney, MH, Harriott, P, Flatt, Peter and O'Harte, Finbarr (2001) Evaluation of glycated insulin in diabetic animals using immunocytochemistry and radioimmunoassay. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 286 (3). pp. 524-528.

Mooney, MH, Gault, Victor, Abdel-Wahab, Yasser, Flatt, Peter and O'Harte, Finbarr (2001) Identification of Tyr(1)-glucitol GIP in intestines of diabetic mice with enhanced insulin-releasing activity. DIABETOLOGIA, 44 (Suppl. 1). pp. 1223.

McKillop, Aine, Mooney, MH, O'Harte, Finbarr and Flatt, Peter (2001) Evaluation of glycated insulin in plasma and biological tissues of diabetic animal models. DIABETOLOGIA, 44 (Suppl. 1). pp. 1222.

McClenaghan, Neville, Ball, AJ and Flatt, Peter (2001) Nateglinide exhibits glucose-sensitive K-ATP channel-dependent and independent insulinotropic actions. DIABETOLOGIA, 44 (Suppl. 1). pp. 824.

Abdel-Wahab, Yasser, Marenah, L, Shaw, C and Flatt, Peter (2001) Isolation and structural characterisation of insulinotropic peptides from Bombina variegata. DIABETOLOGIA, 44 (Suppl. 1). pp. 516.

Gault, Victor, Harriott, P, Flatt, Peter and O'Harte, Finbarr (2001) GIP analogues substituted at Ala(2) exhibit improved plasma stability and insulin-releasing activity. DIABETOLOGIA, 44 (Suppl. 1). pp. 747.

O'Harte, Finbarr, Gault, Victor, Harriott, P, Parker, JC and Flatt, Peter (2001) DPP IV resistant N-terminally modified GIP analogues with enhanced insulinotropic activity. DIABETOLOGIA, 44 (Suppl. 1). pp. 746.

Flatt, Peter, Gault, Victor, Harriott, P and O'Harte, Finbarr (2001) Antagonist actions of novel (Pro(3))GIP analogue and GIP(3-42) on cyclic AMP production and insulin secretion. DIABETOLOGIA, 44 (Suppl. 1). pp. 748.

Brennan, L, Shine, A, Hewage, C, Brindle, KM, Malthouse, JPG, McClenaghan, Neville, Flatt, Peter and Newsholme, P (2001) A NMR study of glucose and alanine metabolism by the beta cell lines RINm5F and BRIN-BD11.. DIABETOLOGIA, 44 (Suppl. 1). pp. 472.

McClenaghan, Neville, Ball, AJ and Flatt, Peter (2001) Specific desensitization of sulfonylurea- but not imidazoline-induced insulin release after prolonged tolbutamide exposure. BIOCHEMICAL PHARMACOLOGY, 61 (5). pp. 527-536.

Hamid, M, McCluskey, Janie, McClenaghan, Neville and Flatt, Peter (2001) Comparative functional study of clonal insulin-secreting cells cultured in five commercially available tissue culture media. CELL TRANSPLANTATION, 10 (2). pp. 153-159.

O'Harte, Finbarr, Mooney, MH, Kelly, CMN, McKillop, Aine and Flatt, Peter (2001) Degradation and glycemic effects of His(7)-glucitol glucagon-like peptide-1(7-36)amide in obese diabetic ob/ob mice. REGULATORY PEPTIDES, 96 (3). pp. 95-104.

Hamid, M, McCluskey, Janie, McClenaghan, Neville and Flatt, Peter (2001) Functional examination of microencapsulated bioengineered insulin-secreting beta-cells. CELL BIOLOGY INTERNATIONAL, 25 (6). pp. 553-556.

Mooney, MH, Flatt, Peter, Gault, Victor and O'Harte, Finbarr (2001) Detection of glycated glucose dependent insulinotropic polypeptide in the intestines of diabetic mice and assessment of its biological activity in vitro. . Irish Journal of Medical Science, 170 (S2). pp. 11-11.

O'Harte, Finbarr, Gault, Victor, Harriott, P, Parker, JC and Flatt, Peter (2001) Stable amino terminally-modified analogues of glucose-dependent insulinotropic polypeptide with improved insulin-releasing activity. . Irish Journal of Medical Science, 170 (S2). pp. 10-10.

Mckillop, Aine, Meade, Angela, Flatt, Peter and O'Harte, Finbarr (2001) Structural characterisation of glycated proinsulin. Irish Journal of Medical Science . Irish Journal of Medical Science, 170. pp. 11.

Lindsay, John, Mckillop, Aine, Mooney, Mark, O'Harte, Finbarr, Flatt, Peter and Bell, Patrick (2001) Detection of glycated insulin in plasma of type 2 diabetic subjects using a novel radioimmunoassay.. Irish Journal of Medical Science, 170. pp. 10.

Ball, AJ, Flatt, Peter and McClenaghan, Neville (2000) Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14R and RX801080. PHARMACOLOGICAL RESEARCH, 42 (6). pp. 575-579.

Ball, AJ, Flatt, Peter and McClenaghan, Neville (2000) Desensitization of sulphonylurea- and nutrient-induced insulin secretion following prolonged treatment with glibenclamide. EUROPEAN JOURNAL OF PHARMACOLOGY, 408 (3). pp. 327-333.

McKillop, Aine, McCluskey, Janie, Boyd, AC, Mooney, MH, Flatt, Peter and O'Harte, Finbarr (2000) Production and characterization of specific antibodies for evaluation of glycated insulin in plasma and biological tissues. JOURNAL OF ENDOCRINOLOGY, 167 (1). pp. 153-163.

O'Harte, Finbarr, Boyd, AC, McKillop, Aine, Abdel-Wahab, Yasser, McNulty, Helene, Barnett, CR, Conlon, JM, Hojrup, P and Flatt, Peter (2000) Structure, antihyperglycemic activity and cellular actions of a novel diglycated human insulin. PEPTIDES, 21 (10). pp. 1519-1526.

Boyd, AC, Abdel-Wahab, Yasser, McKillop, Aine, McNulty, Helene, Barnett, CR, O'Harte, Finbarr and Flatt, Peter (2000) Impaired ability of glycated insulin to regulate plasma glucose and stimulate glucose transport and metabolism in mouse abdominal muscle. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1523 (1). pp. 128-134.

Ahmad, M, Flatt, Peter, Furman, BL and Pyne, NJ (2000) The role of the cyclic GMP-inhibited cyclic AMP-specific phosphodiesterase (PDE3) in regulating clonal BRIN-BD11 insulin secreting cell survival. CELLULAR SIGNALLING, 12 (8). pp. 541-548.

O'Harte, Finbarr, McKillop, Aine, Mooney, MH and Flatt, Peter (2000) Development and use of a specific radioimmunoassay for detection of glycated insulin in diabetes. DIABETOLOGIA, 43 (Suppl. 1). pp. 208.

Flatt, Peter, Ball, AJ and McClenaghan, Neville (2000) GLP-1(7-36)amide enhances K-ATP channel-dependent and -independent insulinotropic actions of sulphonylureas. DIABETOLOGIA, 43 (Suppl. 1). pp. 119.

Stickings, P, Brown, G, Flatt, Peter and Cunningham, JM (2000) Tetrahydrobiopterin synthesis and cytokine-induced NO production in BRIN BD11 cells and rat islets. DIABETOLOGIA, 43 (Suppl. 1). pp. 474.

O'Harte, Finbarr, Mooney, MH, Kelly, CMN and Flatt, Peter (2000) Improved glycaemic control in obese diabetic ob/ob mice using N-terminally modified gastric inhibitory polypeptide. JOURNAL OF ENDOCRINOLOGY, 165 (3). pp. 639-648.

Hamid, M, McCluskey, Janie, McClenaghan, Neville and Flatt, Peter (2000) Culture and function of electrofusion-derived clonal insulin-secreting cells immobilized on solid and macroporous microcarrier beads. BIOSCIENCE REPORTS, 20 (3). pp. 167-176.

Salgado, AP, Santos, RM, Fernandes, AP, Tome, AR, Flatt, Peter and Rosario, LM (2000) Glucose-mediated Ca2+ signalling in single clonal insulin-secreting cells: evidence for a mixed model of cellular activation. INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY, 32 (5). pp. 557-569.

McClenaghan, Neville, Ball, AJ and Flatt, Peter (2000) Induced desensitization of the insulinotropic effects of antidiabetic drugs, BTS 67 582 and tolbutamide. BRITISH JOURNAL OF PHARMACOLOGY, 130 (2). pp. 478-484.

Ball, AJ, McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2000) Drug-induced desensitization of insulinotropic actions of sulfonylureas. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 271 (1). pp. 234-239.

O'Harte, Finbarr, Mooney, MH, Lawlor, A and Flatt, Peter (2000) N-terminally modified glucagon-like peptide-1(7-36) amide exhibits resistance to enzymatic degradation while maintaining its antihyperglycaemic activity in vivo. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1474 (1). pp. 13-22.

Ahmad, M, Abdel-Wahab, Yasser, Tate, R, Flatt, Peter, Pyne, NJ and Furman, BL (2000) Effect of type-selective inhibitors on cyclic nucleotide phosphodiesterase activity and insulin secretion in the clonal insulin secreting cell Line BRIN-BD11. BRITISH JOURNAL OF PHARMACOLOGY, 129 (6). pp. 1228-1234.

Conroy, SJ, Abdel-Wahab, Yasser, Caraher, EM, Byrne, PM, Murphy, E, Nolan, J, Flatt, Peter and Newsholme, P (2000) Evidence for complement-dependent and -independent inhibition of insulin secretion from clonal beta-cells incubated in the presence of sera of newly diagnosed IDDM patients. JOURNAL OF ENDOCRINOLOGY, 164 (2). pp. 139-147.

McKillop, Aine, Abdel-Wahab, Yasser and Flatt, Peter (2000) The traditional plant treatment, Sambucus nigra (elder), exhibits insulin-like and insulin-releasing actions in vitro. JOURNAL OF NUTRITION, 130 (1). pp. 15-20.

Gray, Alison, Abdel-Wahab, Yasser and Flatt, Peter (2000) Insulin-like and insulin-releasing actions of the traditional antidiabetic plant Sambucus nigra (elder).. Journal of Nutrition, 130 (1). pp. 15-20.

McClenaghan, Neville and Flatt, Peter (2000) Metabolic and K-ATP channel-independent actions of keto acid initiators of insulin secretion. PANCREAS, 20 (1). pp. 38-46.

Chapman, JC, McClenaghan, Neville, Cosgrove, KE, Hashmi, MN, Shepherd, RM, Giesberts, AN, White, SJ, Ammala, C, Flatt, Peter and Dunne, MJ (1999) ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line. DIABETES, 48 (12). pp. 2349-2357.

Abdel-Wahab, Yasser, O'Harte, Finbarr, Mooney, MH, Conlon, JM and Flatt, Peter (1999) N-terminal glycation of cholecystokinin-8 abolishes its insulinotropic action on clonal pancreatic B-cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1452 (1). pp. 60-67.

Dunne, MJ, Chapman, JC, McClenaghan, Neville, Hashmi, MN, Shepherd, RM, Cosgrove, KE, Giesberts, AN, White, SJ and Flatt, Peter (1999) The imidazoline efaroxan influences SUR1 protein expression in insulin-secreting cells.. DIABETOLOGIA, 42 (Suppl. 1). pp. 483.

Ball, AJ, Flatt, Peter and McClenaghan, Neville (1999) BTS 67 582 has common and distinct beta cell actions to sulphonylurea and imidazoline drugs. DIABETOLOGIA, 42 (Suppl. 1). pp. 919.

O'Harte, Finbarr, Mooney, MH, Kelly, CMN and Flatt, Peter (1999) Improved stability and glycaemic control with His(7)-glucitol glucagon-like peptide-1 in normal and diabetic rodents. DIABETOLOGIA, 42 (Suppl. 1). pp. 745.

McClenaghan, Neville, Ball, AJ and Flatt, Peter (1999) Downregulation of K-ATP-channel-dependent and -independent insulinotropic actions of tolbutamide. DIABETOLOGIA, 42 (Suppl. 1). pp. 479.

Salgado, AP, Pereira, FC, Seica, RM, Fernandes, AP, Flatt, Peter, Santos, RM, Rosario, LM and Ramasamy, R (1999) Modulation of glucose-induced insulin secretion by cytosolic redox state in clonal beta-cells. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 154 (1-2). pp. 79-88.

Barnes, PD, O'Brien, RE, Abdel-Wahab, Yasser, Cosgrove, KE, Flatt, Peter and Dunne, MJ (1999) Hydrochlorothiazide: An hyperglycaemia-inducing agent and K-ATP channel agonist in human beta-cells and clonal insulin-secreting cells.. DIABETOLOGIA, 42 (Suppl. 1). pp. 482.

Abdel-Wahab, Yasser, Mooney, MH, O'Harte, Finbarr and Flatt, Peter (1999) N-terminal glycation of CCK-8 abolishes its insulinotropic action on clonal B-cells. DIABETOLOGIA, 42 (Suppl. 1). pp. 545.

McClenaghan, Neville and Flatt, Peter (1999) Physiological and pharmacological regulation of insulin release: insights offered through exploitation of insulin-secreting cell lines. DIABETES OBESITYAND METABOLISM, 1 (3). pp. 137-150.

O'Harte, Finbarr, Mooney, MH and Flatt, Peter (1999) NH2-terminally modified gastric inhibitory polypeptide exhibits amino-peptidase resistance and enhanced antihyperglycemic activity. DIABETES, 48 (4). pp. 758-765.

Gray, Alison and Flatt, Peter (1999) Insulin-secreting activity of the traditional antidiabetic plant Viscum album (mistletoe). JOURNAL OF ENDOCRINOLOGY, 160 (3). pp. 409-414.

Gray, Alison and Flatt, Peter (1999) Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander). BRITISH JOURNAL OF NUTRITION, 81 (3). pp. 203-209.

McClenaghan, Neville and Flatt, Peter (1999) Engineering cultured insulin-secreting pancreatic B-cell lines. JOURNAL OF MOLECULAR MEDICINE-JMM, 77 (1). pp. 235-243.

McClenaghan, Neville and Flatt, Peter (1999) Glucose and non-glucidic nutrients exert permissive effects on 2-keto acid regulation of pancreatic beta-cell function. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1426 (1). pp. 110-118.

Gault, Victor, Harriott, P, Flatt, Peter and O'Harte, Finbarr (1999) Stability of GIP and amino terminally modified GIP analogues to DPP IV and human plasma. Digestion, 60. pp. 504-504.

Gray, Alison and Flatt, Peter (1998) Antihyperglycemic actions of Eucalyptus globulus (eucalyptus) are associated with pancreatic and extra-pancreatic effects in mice. JOURNAL OF NUTRITION, 128 (12). pp. 2319-2323.

O'Harte, Finbarr, Mooney, MH, Kelly, CMN and Flatt, Peter (1998) Glycated cholecystokinin-8 has an enhanced satiating activity and is protected against enzymatic degradation. DIABETES, 47 (10). pp. 1619-1624.

O'Harte, Finbarr, Abdel-Wahab, Yasser, Conlon, JM and Flatt, Peter (1998) Glycation of glucagon-like peptide-1(7-36)amide: characterization and impaired action on rat insulin secreting cells. DIABETOLOGIA, 41 (10). pp. 1187-1193.

O'Harte, Finbarr, Abdel-Wahab, Yasser, Conlon, JM and Flatt, Peter (1998) Amino terminal glycation of gastric inhibitory polypeptide enhances its insulinotropic action on clonal pancreatic B-cells. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1425 (2). pp. 319-327.

McClenaghan, Neville, Barnett, CR and Flatt, Peter (1998) Na+ cotransport by metabolizable and nonmetabolizable amino acids stimulates a glucose-regulated insulin-secretory response. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 249 (2). pp. 299-303.

O'Harte, Finbarr, Mooney, M and Flatt, Peter (1998) Glycated gastric inhibitory polypeptide exhibits amino-peptidase resistance and enhanced insulinotropic activity.. DIABETOLOGIA, 41 (Suppl. 1). pp. 712.

Mooney, M, Kelly, CMN, Flatt, Peter and O'Harte, Finbarr (1998) Aminopeptidase resistant glycated glucagon-like peptide-1[7-36]amide shows potent insulinotropic action in vivo.. DIABETOLOGIA, 41 (Suppl. 1). pp. 713.

McClenaghan, Neville and Flatt, Peter (1998) Metabolic and K+-ATP channel-independent secretory actions of glucose and 2-keto acids in clonal beta-cells. DIABETOLOGIA, 41 (Suppl. 1). pp. 545.

Abdel-Wahab, Yasser, Davies, EL, Bailey, CJ and Flatt, Peter (1998) Enhanced function of electrofusion-derived surrogate B-cells implanted in diabetic nude mice. DIABETOLOGIA, 41 (Suppl. 1). pp. 511.

Flatt, Peter, Abdel-Wahab, Yasser, Ahmad, M, Pyne, NJ and Furman, BL (1998) Characterisation and functional role of cyclic AMP phosphodiesterases in clonal beta-cells. DIABETOLOGIA, 41 (Suppl. 1). pp. 521.

Gray, Alison and Flatt, Peter (1998) Actions of the traditional anti-diabetic plant, Agrimony eupatoria (agrimony): effects on hyperglycaemia, cellular glucose metabolism and insulin secretion. BRITISH JOURNAL OF NUTRITION, 80 (1). pp. 109-114.

Gray, Alison and Flatt, PR (1998) Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom). JOURNAL OF ENDOCRINOLOGY, 157 (2). pp. 259-266.

Ahmad, M, Abdel-Wahab, Yasser, Pyne, NJ, Flatt, Peter and Furman, BL (1998) Effects of type selective inhibitors can cAMP phosphodiesterase activity and insulin secretion in the clonal beta cell BRIN BD11. BRITISH JOURNAL OF PHARMACOLOGY, 123 (Suppl. S). pp. 156P.

O'Harte, Finbarr, Gray, Alison and Flatt, Peter (1998) Gastric inhibitory polypeptide and effects of glycation on glucose transport and metabolism in isolated mouse abdominal muscle. JOURNAL OF ENDOCRINOLOGY, 156 (2). pp. 237-243.

McClenaghan, Neville, Flatt, Peter and Bailey, CJ (1998) Insulin-releasing action of the novel antidiabetic agent BTS 67 582. BRITISH JOURNAL OF PHARMACOLOGY, 123 (3). pp. 400-404.

O'Harte, Finbarr, Abdel-Wahab, Yasser, Conlon, JM and Flatt, Peter (1998) Glycated IAPP shows a reduced inhibitory action on insulin secretion.. BIOCHEMICAL SOCIETY TRANSACTIONS, 26 (1). pp. S6.

Ding, XZ, Flatt, Peter, Permert, J and Adrian, TE (1998) Pancreatic cancer cells selectively stimulate islet beta cells to secrete amylin. GASTROENTEROLOGY, 114 (1). pp. 130-138.

Gray, Alison and Flatt, Peter (1997) Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, Medicago sativa (lucerne). BRITISH JOURNAL OF NUTRITION, 78 (2). pp. 325-334.

Chapman, JC, Cosgrove, K, McClenaghan, Neville, Ammala, C, Flatt, Peter and Dunne, MJ (1997) Properties of ion channels and the regulation of insulin secretion in the novel glucose-responsive beta-cell line, BRIN-BD11. DIABETOLOGIA, 40 (Suppl. 1). pp. 390.

Salgado, AP, Fernandes, AP, Pereira, FC, Seica, RM, Flatt, Peter, Santos, RM, Rosario, LM and Ramasamy, R (1997) Modulation of glucose-induced insulin secretion by cytosolic redox state in BRIN-BD11 cells. DIABETOLOGIA, 40 (Suppl. 1). pp. 421.

Clarke, J, Flatt, Peter and Barnett, CR (1997) Cytochrome P450 1A-like proteins expressed in the islets of Langerhans and altered pancreatic beta-cell secretory responsiveness. BRITISH JOURNAL OF PHARMACOLOGY, 121 (3). pp. 389-394.

Gray, Alison and Flatt, Peter (1997) Nature's own pharmacy: The diabetes perspective. PROCEEDINGS OF THE NUTRITION SOCIETY, 56 (1B). pp. 507-517.

Flatt, Peter, Abdel-Wahab, Yasser, Boyd, AC, Barnett, CR and Flatt, Peter (1997) Pancreatic B-cell dysfunction and glucose toxicity in non-insulin-dependent diabetes. PROCEEDINGS OF THE NUTRITION SOCIETY, 56 (1B). pp. 243-262.

Bailey, CJ, Day, C, Knapper, JME, Turner, SL and Flatt, Peter (1997) Antihyperglycaemic effect of saccharin in diabetic ob/ob mice. BRITISH JOURNAL OF PHARMACOLOGY, 120 (1). pp. 74-78.

Abdel-Wahab, Yasser, O'Harte, Finbarr, Barnett, CR and Flatt, Peter (1997) Characterization of insulin glycation in insulin-secreting cells maintained in tissue culture. JOURNAL OF ENDOCRINOLOGY, 152 (1). pp. 59-67.

O'Harte, Finbarr, Gallagher, Alison, Abdel-Wahab, Yasser and Flatt, Peter (1997) Effects of non-glycated and glycated glucagon-like peptide-1(7-36) amide on glucose metabolism in isolated mouse abdominal muscle. PEPTIDES, 18 (9). pp. 1327-1333.

O'Harte, FPM, Gray, Alison, Abdel-Wahab, Yasser and Flatt, Peter (1997) Effects of glycated and non-glycated gastric inhibitory polypeptide on glucose transport and metabolism in isolated mouse abdominal muscle.. Proceedings of the Nutrition Society, 56 (1A). pp. 42A.

Boyd, AC, O'Harte, FPM, Gray, Alison, Abdel-Wahab, Yasser, Barnett, CR and Flatt, Peter (1997) Mono- and di-glycated insulin exhibit reduced cellular glucose uptake and glucose lowering activity in mice.. Proceedings of the Nutrition Society, 56 (1A). pp. 43A.

Gray, Alison and Flatt, Peter (1997) Evaluation of the antidiabetic effects of coriander (Coriandrum sativum).. Proceedings of the Nutrition Society, 56 (1A). pp. 45A.

Gray, Alison and Flatt, Peter (1997) effects of a traditional anti-diabetic plant, Sambucus nigra (elder), on glucose metabolism and insulin secretion.. Proceedings of the Nutrition Society, 56 (3). pp. 300A.

Gray, Alison and Flatt, Peter (1997) Eucalyptus globulus, antihyperglycaemic actions and effects on cellular metabolism and insulin secretion.. Diabetic Medicine, 14 (1). pp. S34.

Abdel-Wahab, Yasser, O'Harte, Finbarr, Boyd, AC, Barnett, CR and Flatt, Peter (1997) Glycation of insulin results in reduced biological activity in mice. ACTA DIABETOLOGICA, 34 (4). pp. 265-270.

Clarke, J, Snelling, J, Ioannides, C, Flatt, Peter and Barnett, CR (1996) Effect of vitamin C supplementation on hepatic cytochrome P450 mixed-function oxidase activity in streptozotocin-diabetic rats. TOXICOLOGY LETTERS, 89 (3). pp. 249-256.

McClenaghan, Neville, Barnett, CR, O'Harte, Finbarr and Flatt, Peter (1996) Mechanisms of amino acid-induced insulin secretion from the glucose-responsive BRIN-BD11 pancreatic B-cell line. JOURNAL OF ENDOCRINOLOGY, 151 (3). pp. 349-357.

Abdel-Wahab, Yasser, O'Harte, Finbarr, Ratcliff, H, McClenaghan, Neville, Barnett, CR and Flatt, Peter (1996) Glycation of insulin in the islets of Langerhans of normal and diabetic animals. DIABETES, 45 (11). pp. 1489-1496.

Rasschaert, J, Flatt, Peter, McClenaghan, Neville and Malaisse, WJ (1996) Amino acid oxidation in BRIN-BD11 islet cells. MEDICAL SCIENCE RESEARCH, 24 (10). pp. 691-692.

McClenaghan, Neville, Barnett, CR and Flatt, Peter (1996) Na+ involvement in glucose and neutral amino acid-induced insulin secretion. DIABETOLOGIA, 39 (Suppl. 1). pp. 424.

Abdel-Wahab, Yasser, O'Harte, Finbarr, Gallagher, Alison and Flatt, Peter (1996) Glycation of GLP-1[7-36]amide but not GIP reduces its insulinotropic action in vitro. DIABETOLOGIA, 39 (Suppl. 1). pp. 84.

O'Harte, Finbarr, Gallagher, Alison, Abdel-Wahab, Yasser and Flatt, Peter (1996) Effects of glycated and non-glycated GLP-1[7-36]amide on glucose metabolism in muscle. DIABETOLOGIA, 39 (Suppl. 1). pp. 82.

Salgado, AP, Santos, RM, Tome, AR, Fernandes, AP, Flatt, Peter and Rosario, LM (1996) Glucose-mediated Ca2+ signalling in the novel insulin secreting cell line BRIN-D 11. DIABETOLOGIA, 39 (Suppl. 1). pp. 439.

Barnett, CR, Clarke, J and Flatt, Peter (1996) Cytochrome P450 CYP4A expression in pancreatic islets of Langerhans. DIABETOLOGIA, 39 (Suppl. 1). pp. 137.

McClenaghan, Neville, Barnett, CR, AhSing, E, Abdel-Wahab, Yasser, O'Harte, Finbarr, Yoon, TW, SwanstonFlatt, SK and Flatt, Peter (1996) Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion. DIABETES, 45 (8). pp. 1132-1140.

Boyd, AC, O'Harte, Finbarr, Gallagher, Alison, Abdel-Wahab, Yasser, McNulty, Helene, Barnett, CR and Flatt, Peter (1996) Reduced biological potency of mono-glycated insulin in vitro and in vivo in mice. DIABETOLOGIA, 39 (Suppl. 1). pp. 83.

McClenaghan, Neville, Gallagher, Alison, Barnett, CR and Flatt, Peter (1996) Hexose recognition by insulin-secreting BRIN-BD11 cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 223 (3). pp. 724-728.

Flatt, Peter (1996) Pancreatic B-cells as mediators of metabolic effects of regulatory peptides. BIOCHEMICAL SOCIETY TRANSACTIONS, 24 (2). pp. 570-575.

Ding, XZ, Flatt, Peter, Permert, J and Adrian, TE (1996) Pancreatic cancer cells selectively stimulate beta islet cells to secrete IAPP. GASTROENTEROLOGY, 110 (4, Suppl. S). pp. A387.

Rasschaert, J, Flatt, Peter, Barnett, CR, McClenaghan, Neville and Malaisse, WJ (1996) D-glucose metabolism in BRIN-BD11 islet cells. BIOCHEMICAL AND MOLECULAR MEDICINE, 57 (2). pp. 97-105.

McClenaghan, Neville, Barnett, CR, O'Harte, Finbarr, SwanstonFlatt, SK, AhSing, E and Flatt, Peter (1996) Characteristics of BRIN-BG5 and BRIN-BG7, two novel glucose-responsive insulin-secreting cell lines produced by electrofusion. JOURNAL OF ENDOCRINOLOGY, 148 (3). pp. 409-417.

Eliasson, L, Renstrom, E, Ammala, C, Berggren, PO, Bertorello, AM, Bokvist, K, Chibalin, A, Deeney, JT, Flatt, Peter, Gabel, J, Gromada, J, Larsson, O, Lindstrom, P, Rhodes, CJ and Rorsman, P (1996) PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells. SCIENCE, 271 (5250). pp. 813-815.

McClenaghan, Neville, Barnett, CR, AhSing, E, SwanstonFlatt, SK and Flatt, Peter (1996) Secretory properties of clonal insulin-secreting BRIN-BG5 cells, produced by electrofusion.. BIOCHEMICAL SOCIETY TRANSACTIONS, 24 (1). pp. S101.

O'Harte, Finbarr, Hojrup, P, Barnett, CR and Flatt, Peter (1996) Identification of the site of glycation of human insulin. PEPTIDES, 17 (8). pp. 1323-1330.

Gray, Alison and Flatt, Peter (1996) Investigation of the efficacy and mode of action of the traditional antidiabetic plant, Agrimony eupatoria.. Diabetic Medicine, 13 (Suppl 3). pp. S22.

Irizar, A, Barnett, CR, Flatt, Peter and Ioannides, C (1995) DEFECTIVE EXPRESSION OF CYTOCHROME-P450 PROTEINS IN THE LIVER OF THE GENETICALLY-OBESE ZUCKER RAT. EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION, 293 (4). pp. 385-393.

McDermott, BM, Strain, JJ and Flatt, Peter (1995) Effects Of Dietary Carbohydrate Intake On Antioxidant Enzyme-Activity And Copper Status In The Copper-Deficient Streptozotocin (Stz) Diabetic Rat. Journal of Nutritional Biochemistry, 6 (12). pp. 638-643.

Barnett, CR, Clarke, J, McClenaghan, Neville and Flatt, Peter (1995) CYTOCHROME-P450 CYP1A EXPRESSION IN THE PANCREATIC-ISLETS OF LANGERHANS. DIABETOLOGIA, 38 (Suppl. 1). pp. A135.

McClenaghan, Neville, Barnett, CR, Swanstonflatt, SK and Flatt, Peter (1995) COMPARISON OF THE GLUCOSE-SENSING ABILITY OF 3 NOVEL GLUCOSE-RESPONSIVE PANCREATIC B-CELL LINES. DIABETOLOGIA, 38 (Suppl. 1). pp. A108.

Clarke, J, McClenaghan, Neville, Barnett, CR, Ahsing, E, Yoon, TW, Swanstonflatt, SK and Flatt, Peter (1995) BRIN-BG7, A NOVEL GLUCOSE-RESPONSIVE INSULIN-SECRETING CELL-LINE PRODUCED BY ELECTROFUSION. DIABETOLOGIA, 38 (Suppl. 1). pp. A108.

Flatt, Peter, O'Harte, Finbarr, Abdel-Wahab, Yasser, McClenaghan, Neville and Barrnett, CR (1995) GLYCATION OF INSULIN AND PROINSULIN OCCURS IN THE ISLETS OF LANGERHANS OF DIABETIC ANIMALS. DIABETOLOGIA, 38 (Suppl. 1). pp. A92.

O'Harte, Finbarr, Hunter, SJ, Boyd, AC, Wiggan, I, Ennis, CN, Gamble, R, Sheridan, B, Barnett, CR, McNulty, Helene, BELL, PM and Flatt, Peter (1995) DETERMINATION OF THE SITE OF GLYCATION OF HUMAN INSULIN AND BIOLOGICAL POTENCY USING EUGLYCEMIC CLAMPS IN MAN. DIABETOLOGIA, 38 (Suppl. 1). pp. A161.

McDermott, BM, Flatt, Peter and Strain, JJ (1994) Effects of copper deficiency and experimental diabetes on tissue antioxidant enzyme levels in rats. Annals of Nutrition and Metabolism, 38 (5). pp. 263-269.

O'Harte, Finbarr, Boyd, AC, Abdel-Wahab, Yasser, Barnett, CR and Flatt, Peter (1994) CHARACTERIZATION OF THE GLYCATION OF HUMAN INSULIN BY REVERSED-PHASE HPLC. BIOCHEMICAL SOCIETY TRANSACTIONS, 22 (2). pp. S239.

Abdel-Wahab, Yasser, O'Harte, Finbarr, Barnett, CR and Flatt, Peter (1994) STUDIES OF THE EFFECT OF GLYCATION OF INSULIN ON GLUCOSE-METABOLISM IN ISOLATED MOUSE DIAPHRAGM MUSCLE. BIOCHEMICAL SOCIETY TRANSACTIONS, 22 (2). pp. S238.

McClenaghan, Neville, Yoon, TW, Barnett, CR, Wilson, AM, Abdel-Wahab, Yasser, Swanstonflatt, S, Ahsing, E and Flatt, Peter (1994) EFFECT OF GLUCOSE AND AMINO-ACIDS ON INSULIN-SECRETION FROM A NOVEL PANCREATIC B-CELL LINE PRODUCED BY ELECTROFUSION. BIOCHEMICAL SOCIETY TRANSACTIONS, 22 (2). pp. S237.

Barnett, CR, Flatt, Peter and Ioannides, C (1994) MODULATION OF THE RAT HEPATIC CYTOCHROME-P450 COMPOSITION BY LONG-TERM STREPTOZOTOCIN-INDUCED INSULIN-DEPENDENT DIABETES. JOURNAL OF BIOCHEMICAL TOXICOLOGY, 9 (2). pp. 63-69.

Flatt, Peter, Shibier, O, Szecowka, J and Berggren, PO (1994) NEW PERSPECTIVES ON THE ACTIONS OF SULPHONYLUREAS AND HYPERGLYCEMIC SULFONAMIDES ON THE PANCREATIC B-CELL. DIABETES AND METABOLISM, 20 (2). pp. 157-162.

Flatt, Peter, Barnett, CR and Swanstonflatt, SK (1994) MECHANISMS OF PANCREATIC B-CELL DYSFUNCTION AND GLUCOSE TOXICITY IN NON-INSULIN-DEPENDENT DIABETES. BIOCHEMICAL SOCIETY TRANSACTIONS, 22 (1). pp. 18-23.

Gray, Alison, Day, C and Flatt, Peter (1994) investigation of the antihyperglycaemic and insulin-releasing effects of Medicago sativa.. Diabetic Medicine, 11 (Suppl 2). pp. S21.

Gray, Alison and Flatt, Peter (1994) Evaluation of the antidiabetic effects of an edible mushroom (Agaricus campestris).. Proceedings of the Nutrition Society, 53 (3). pp. 125A.

Bailey, CJ and Flatt, Peter (1993) ISLET DEFECTS AND INSULIN-RESISTANCE IN MODELS OF OBESE NON-INSULIN-DEPENDENT DIABETES. DIABETES-METABOLISM REVIEWS, 9 (Suppl. 1). pp. S43-S50.

Barnett, CR, Flatt, Peter and Berggren, PO (1993) REVERSAL OF TEMPERATURE-DEPENDENT INHIBITION OF INSULIN-SECRETION IN RINM5F CELLS BY PERTUSSIS TOXIN. DIABETOLOGIA, 36 (Suppl. 1). pp. A112.

Flatt, Peter, Yoon, TW, Barnett, CR, McClenaghan, Neville, Wilson, AM, Abdel-Wahab, Yasser, Ahsing, E and Swanstonflatt, SK (1993) PRODUCTION OF A NOVEL GLUCOSE-RESPONSIVE INSULIN-SECRETING PANCREATIC B-CELL LINE BY ELECTROFUSION. DIABETOLOGIA, 36 (Suppl. 1). pp. A31.

Barnett, CR, Rudd, S, Flatt, Peter and Ioannides, C (1993) SEX-DIFFERENCES IN THE DIABETES-INDUCED MODULATION OF RAT HEPATIC CYTOCHROME-P450 PROTEINS. BIOCHEMICAL PHARMACOLOGY, 45 (2). pp. 313-319.

Barnett, CR, Petrides, L, Wilson, J, Flatt, Peter and Ioannides, C (1992) INDUCTION OF RAT HEPATIC MIXED-FUNCTION OXIDASES BY ACETONE AND OTHER PHYSIOLOGICAL KETONES - THEIR ROLE IN DIABETES-INDUCED CHANGES IN CYTOCHROME P450 PROTEINS. XENOBIOTICA, 22 (12). pp. 1441-1450.

Szecowka, J, Shibier, O, Flatt, Peter, Berggren, PO, Ostenson, CG and Efendic, S (1992) PANCREASTATIN BINDING-SITES AND ACTION IN INTACT AND PERMEABILIZED RINM5F CELLS. DIABETOLOGIA, 35 (Suppl. 1). pp. A76.

Flatt, Peter, Shibier, O, Sandberg, E, Ostenson, CG, Efendic, S and Berggren, PO (1992) INHIBITION OF INSULIN RELEASE BY DIAZEPAM-BINDING INHIBITOR (DBI) INVOLVES INTERACTIONS WITH PROTEIN-KINASE-C AND AN INHIBITORY G-PROTEIN. DIABETOLOGIA, 35 (Suppl. 1). pp. A113.

Knapper, JME and Flatt, Peter (1992) EFFECTS OF SUGARS ON THE RELEASE OF IR-GLP-1 (7-36)AMIDE AND IR-GIP BY ISOLATED RAT SMALL-INTESTINE. REGULATORY PEPTIDES, 39 (2-3). pp. 273.

Barnett, CR, Flatt, Peter and Ioannides, C (1992) THE MODULATION OF HEPATIC MIXED-FUNCTION OXIDASE ACTIVITY BY INSULINOMA. REGULATORY PEPTIDES, 39 (2-3). pp. 273.

Barnett, CR, Abbott, RA, Bailey, CJ, Flatt, Peter and Ioannides, C (1992) CYTOCHROME-P450-DEPENDENT MIXED-FUNCTION OXIDASE AND GLUTATHIONE-S-TRANSFERASE ACTIVITIES IN SPONTANEOUS OBESITY-DIABETES. BIOCHEMICAL PHARMACOLOGY, 43 (8). pp. 1868-1871.

Barnett, CR, Wilson, J, Wolf, CR, Flatt, Peter and Ioannides, C (1992) HYPERINSULINEMIA CAUSES A PREFERENTIAL INCREASE IN HEPATIC P4501A2 ACTIVITY. BIOCHEMICAL PHARMACOLOGY, 43 (6). pp. 1255-1261.

Swanstonflatt, SK, Flatt, Peter, Day, C and Bailey, CJ (1991) TRADITIONAL DIETARY ADJUNCTS FOR THE TREATMENT OF DIABETES-MELLITUS. PROCEEDINGS OF THE NUTRITION SOCIETY, 50 (3). pp. 641-651.

Flatt, Peter, Barnett, CR, Shibier, O and Swanstonflatt, SK (1991) DIRECT AND INDIRECT ACTIONS OF NUTRIENTS IN THE REGULATION OF INSULIN-SECRETION FROM THE PANCREATIC BETA-CELLS. PROCEEDINGS OF THE NUTRITION SOCIETY, 50 (3). pp. 559-566.

Williams, G, Cardoso, H, Lee, YC, Ghatei, MA, Flatt, Peter, Bailey, CJ and Bloom, SR (1991) REDUCED HYPOTHALAMIC NEUROTENSIN CONCENTRATIONS IN THE GENETICALLY-OBESE DIABETIC (OB/OB) MOUSE - POSSIBLE RELATIONSHIP TO OBESITY. METABOLISM-CLINICAL AND EXPERIMENTAL, 40 (10). pp. 1112-1116.

Ponter, AA, Salter, DN, Morgan, LM and Flatt, Peter (1991) THE EFFECT OF ENERGY-SOURCE AND FEEDING LEVEL ON THE HORMONES OF THE ENTEROINSULAR AXIS AND PLASMA-GLUCOSE IN THE GROWING PIG. BRITISH JOURNAL OF NUTRITION, 66 (2). pp. 187-197.

Flatt, Peter, Bailey, CJ and Conlon, JM (1991) SOMATOSTATIN, GASTRIN-RELEASING PEPTIDE AND GASTRIN IN THE STOMACH OF RATS WITH STREPTOZOTOCIN-INDUCED DIABETES AND INSULINOMA. JOURNAL OF NUTRITION, 121 (9). pp. 1414-1417.

Flatt, Peter, Kwasowski, P, Howland, RJ and Bailey, CJ (1991) GASTRIC-INHIBITORY POLYPEPTIDE AND INSULIN RESPONSES TO ORALLY-ADMINISTERED AMINO-ACIDS IN GENETICALLY-OBESE HYPERGLYCEMIC (OB/OB) MICE. JOURNAL OF NUTRITION, 121 (7). pp. 1123-1128.

Flatt, Peter, Swanstonflatt, SK, Bailey, CJ, McGregor, GP and Conlon, JM (1991) SUBSTANCE-P, NEUROKININ-A AND CALCITONIN GENE-RELATED PEPTIDE DURING DEVELOPMENT OF THE RAT GASTROINTESTINAL-TRACT. REGULATORY PEPTIDES, 33 (3). pp. 313-320.

Flatt, Peter and Bailey, CJ (1991) MOLECULAR MECHANISMS OF INSULIN-SECRETION AND INSULIN ACTION. JOURNAL OF BIOLOGICAL EDUCATION, 25 (1). pp. 9-14.

Hoftiezer, V, Bankston, PW, Flatt, Peter, Welch, M and Berggren, PO (1986) MORPHOLOGICAL EVIDENCE OF RETROVIRUS-LIKE PARTICLES IN CLONAL INSULIN-PRODUCING RINM5F CELLS. JOURNAL OF CELL BIOLOGY, 103 (5, Part 2). pp. A424.

This list was generated on Thu Dec 18 08:28:16 2014 GMT.