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Gibson, David Dr

Lecturer in Stratified Medicine

Academic and Professional Qualifications

- 2012 Good Clinical Practice training, Ashford and St. Peter’s Hospitals NHS Trust, UK

- 2007 Fellow of the Higher Education Academy

- 2006 Postgraduate Certificate in Higher Education Teaching, Queen’s University Belfast

- 2005 E-tutor Certificate, Campus One, University of Ulster

- 2002 NILTG for Animal Scientific Procedures Certificate (Personal License)

- 2001 PhD Oncology, CCRCB, Queen’s University of Belfast

- 1995 BSc Hons Biochemistry, Queen’s University of Belfast

Career History

After his Biochemistry degree, Dr David Gibson worked at Randox Laboratories Ltd, where he was responsible for designing and commercializing novel biochip array diagnostic tests. He was awarded a Ph.D. in 2001 from the Centre for Cancer Research and Cell Biology, Queen’s University Belfast, for research which exposed the role of cysteine proteinases in brain tumour invasion. During a Wellcome Trust Fellowship Dr Gibson investigated the role of inflammation in a hypoxia driven model of diabetic retinopathy at the Centre of Vision and Vascular Science, QUB.

Since 2003 Dr Gibson focused his research efforts on the discovery and validation of protein biomarkers which could improve the management of arthritis patients. During his time at the Rooney laboratory in the Centre of Infection and Immunity, QUB he spearheaded the use of proteomic and bioinformatic strategies to identify a plasma and synovial fluid protein ‘fingerprint’ that predicts disease spread in children with arthritis. He also identified post translational modifications in the Vitamin D binding protein that may act as a modulator of inflammation in juvenile arthritis patients.

In 2009, Dr Gibson was awarded a prestigious travel fellowship from Arthritis Research UK to conduct research at the Duncan laboratory at the University of Colorado, Denver over two years. From this fellowship Dr Gibson brings expertise in mass spectrometry analyses of clinically relevant proteins, peptides and post-translational modifications to his current post at the University of Ulster.

Research Interests

Stratified Medicine- ‘the right treatment, for the right person, at the right time’

In 2013 Dr Gibson took up his post as Lecturer in Stratified Medicine and his research is focused on adult rheumatoid arthritis (RA). He is particularly interested in the development of new prognostic and predictive tools to improve the clinical management of arthritis patients. David’s current research within the Northern Ireland Centre for Stratified Medicine is based at C-TRIC within the Altnagelvin Hospital campus, Londonderry.

He employs novel mass spectrometry based methods to robustly identify and quantify disease associated proteins. These methods are useful to investigate the role of protein modification in arthritis, as a surrogate measure of inflammatory activity. He is also interested in the application of protein array technologies for autoantibody screening. He will initially establish research programmes in three key areas: 1. How RA patients develop resistance to biologic therapies. 2. How inflammation and joint destruction can persist without clinical symptoms. 3. Can alternate methods of blood sampling support patient care away from the hospital clinic. Ultimately, Dr Gibson will develop novel monitoring tools to help clinicians target those patients who do not respond well to current therapeutics or develop drug resistance over time. This would allow earlier more effective treatments in RA patients, thus preventing joint damage and reducing disability.

Teaching & Learning Activities   Modules:
- 1. Inflammatory and Immunological Disease,
- 2. Genetic Inheritance/ Genomics, Proteomics and Metabolomics,
- 3. In Silico Genomic, Proteomic and Metabolomic analysis methods.

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Gibson, David Dr


Gibson, David Dr - Publications

Number of items: 49.

Pattison, SH, Gibson, DS, Johnston, E, Peacock, S, Rivera, K, Tunney, MM, Pappin, DJ and Elborn, JS (2017) Proteomic profile of cystic fibrosis sputum cells in adults chronically infected with Pseudomonas aeruginosa. European Respiratory Journal, 49.

Callan, N, Butt, A, Pennington, SR, McGeough, C, Gardiner, P, Wright, G, Bjourson, AJ and Gibson, DS (2016) Design of a Multiplex Serum Proteome Assay to Monitor Biologic Drug Response in Rheumatoid Arthritis Patients. Arthritis & Rheumatology, 68 (Suppl).

Gibson, DS and Rooney, ME (2016) Musculoskeletal Diseases. PROTEOMICS - Clinical Applications, 10 (6). pp. 623-624.

Eakin, Amanda, Bustard, Michael, McGeough, Cathy, Ahmed, Tahanver, Bjourson, AJ and Gibson, David (2016) Siglec 1 and 2 as potential biomarkers in autoimmune disease. Proteomics Clinical Applications, TBC.

Collins, ES, Butt, AQ, Gibson, DS, Dunn, M, Fearon, U, van Kuijk, AW, Gerlag, DM, Pontifex, E, Veale, DJ, Tak, PP, Fitzgerald, O and Pennington, SR (2015) A Clinically Based Protein Discovery Strategy to Identify Potential Biomarkers of Response to Anti-TNF-alpha Treatment of Psoriatic Arthritis. Proteomics Clinical Applications, ?.

Butt, Aisha Q, McArdle, Angela, Gibson, David, Fitzgerald, Oliver and Pennington, Stephen R (2015) Psoriatic arthritis under a proteomic spotlight: application of novel technologies to advance diagnosis and management. Current Rheumatology Reports, 17 (5). pp. 509.

Bian, X, Wiktor, P, Kahn, P, Khela, A, Karthikeyan, K, Barker, K, Yu, X, Magee, M, Wasserfall, CH, Gibson, David, Rooney, ME, Qiu, J and LaBaer, J (2015) Anti-viral antibody profiling by high density protein arrays.. Proteomics, Tbc.

Gibson, David S, Bustard, Michael, McGeough, Cathy, Murray, Helena A, Crockard, Martin A, McDowell, Andrew, Blayney, Jaine, Gardiner, Philip and Bjourson, AJ (2014) Current and future trends in biomarker discovery and development of companion diagnostics for arthritis. Expert Review of Molecular Diagnostics, Early.

Duncan, Mark W, Gibson, David, Walsh, Ryan, Massod, Afsham and Benabdelkamel, Hicham (2014) An Overview of Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry and Some of Its Applications. In: Detection of Chemical, Biological, Radiological and Nuclear Agents for the Prevention of Terrorism, NATO Science for Peace and Security Series A: Chemistry and Biology. Springer Science, Dordrecht, Germany, pp. 69-81. ISBN 978-94-017-9237-0

Alfadda, AA, Turjoman, AA, Moustafa, AS, Al-Naami, MY, Chishti, MA, Sallam, RM, Gibson, David and Duncan, MW (2014) A proteomic analysis of excreted and circulating proteins from obese patients following two different weight-loss strategies. Exp Biol Med, 239 (5). pp. 568-580.

Shyamsundar, M, McAuley, DF, Ingram, RJ, Gibson, David, O'Kane, D, McKeown, ST, Edwards, A, Taggart, C, Elborn, JS, Calfee, CS, Matthay, MA and O'Kane, CM (2014) Keratinocyte Growth-Factor Promotes Epithelial Survival and Resolution in a Human Model of Lung Injury. American Journal of Respiratory and Critical Care Medicine, 189 (12). pp. 1520-1529.

Ball, EM, Gibson, David, Bell, AL and Rooney, MR (2014) Plasma IL-6 levels correlate with clinical and ultrasound measures of arthritis in patients with systemic lupus erythematosus.. Lupus, 23 (1). pp. 45-56.

Finnegan, S, Robson, J, Scaife, C, McAllister, C, Pennington, SR, Gibson, David and Rooney, ME (2014) Synovial membrane protein expression differs between juvenile idiopathic arthritis subtypes in early disease. Arthritis Research and Therapy, 16 (1). pp. R8.

Gibson, David, Qiu, Ji, Finnegan, Sorcha, Mendoza, EA, Barker, K, McAllister, C, LaBaer, Joshua and Rooney, Madeleine (2014) Autoantibodies Predictive of Uveitis in Juvenile Idiopathic Arthritis (Aperture): a proof of concept study. In: British Society for Paediatric and Adolescent Rheumatology. Oxford Journals. Vol 53 (Sup 3), iii2

Alhaider, A, Abdelgader, AG, Turjoman, AA, Newell, K, Hunsucker, SW, Shan, B, Ma, B, Gibson, DS and Duncan, MW (2013) Through the eye of an electrospray needle: mass spectrometric identification of themajor peptides and proteins in the milk of the one-humped camel (Camelus dromedarius). Journal of Mass Spectrometry, 48 (7). pp. 779-794.

Rooney, MR, Finnegan, S and Gibson, David (2013) Identification of Uveitis-Specific Autoantibodies in Children with Juvenile Arthritis: Comparison of the Plasma Profiles of Uveitis, Non-Uveitis and Aged-Matched Controls. In: British Society for Rheumatology Annual Meeting, Birmingham, UK. Oxford University Press. Vol 52 (suppl), 120

McGeough, Cathy, Gibson, David, Slevin, Mary, Wright, Gary, Gardiner, Philip, Fitzgerald, Oliver and Bjourson, AJ (2013) Prevalence of KIR B haplotype in Irish rheumatoid arthritis patients. In: European League Against Rheumatism, Madrid, Spain. BMJ Publishing Group Ltd. Vol 72 (Supp 3), A786

Duncan, Mark and Gibson, David (2012) Mass Spectrometry for Peptide and Protein Analysis. In: Encyclopedia of Analytical Chemistry. John Wiley & Sons, Ltd., Encyclopedia of Analytical Chemistry, pp. 1-22. ISBN ISBN: 9780470027318

Gibson, David, Qiu, Ji, Mendoza, Eliseo, Barker, Kristi, Rooney, Madeleine and LaBaer, Joshua (2012) Circulating and synovial antibody profiling of juvenile arthritis patients bynucleic acid programmable protein arrays. Arthritis Research and Therapy, 14 (2). pp. R77.

Pattison, Sally, Johnston, E, Gibson, David, Pappin, D and Elborn, JS (2012) Proteomic analysis of the chronically infected CF airways. In: 35th European Cystic Fibrosis Conference, Dublin, Ireland. Elsevier B.V..

Pattison, S, Johnston, E, Gibson, David, Pappin, D and Elborn, JS (2012) Antibiotic treatment of exacerbation of chronic airways infection. In: 35th European Cystic Fibrosis Conference, Dublin, Ireland. Elsevier B.V..

Gibson, David, Pascoli, Laura, McAllister, Catherine, Scaife, Catriona, Dunn, Michael, Pennington, Stephen and Rooney, Madeleine (2012) Increased Vitamin D Binding Protein Expression in JIA Patients Suffering Disease Extension. In: British Society for Rheumatology Annual Meeting, Birmingham, UK. Oxford Journals. Vol 49 (suppl), i86-i89

Gibson, David, Newell, Keri, Evans, Alexandra, Finnegan, Sorcha, Manning, Gwen, Scaife, Caitiona, McAllister, Catherine, Pennington, Stephen, Duncan, Mark, Moore, Terry and Rooney, Madeleine (2012) Vitamin D binding protein isoforms as candidate predictors of disease extension in childhood arthritis. Journal of Proteomics, 75. pp. 5479-5492.

Gibson, David, Rooney, Madeleine, Finnegan, Sorcha, Qiu, Ji, Thompson, David, LaBaer, Joshua, Pennington, Stephen and Duncan, Mark (2012) Biomarkers in rheumatology, now and in the future. Rheumatology (Oxford), 51. pp. 423-433.

Doyle, Timothy, Gibson, David, Clarke, Susan and Jordan, Grant (2012) An investigation into the use of human bone marrow osteogenic cells in the treatment of bone defects. In: British Orthopaedic Research Society (BORS), Cardiff, Wales, 12 - 13 July 2010. British societ of bone and joint surgery. Vol 94-B (S XVII), 042

Gibson, David S., Finnegan, Sorcha, Pennington, Stephen R., Qiu, Ji, LaBaer, Joshua, Rooney, Madeleine E. and Duncan, Mark W. (2011) Validation of Protein Biomarkers to Advance the Management of Autoimmune Disorders. In: Autoimmune Disorders - Current Concepts and Advances from Bedside to Mechanistic Insights. Intech, Croatia/online, pp. 1-29. ISBN ISBN 978-953-307-653-9

Finnegan, Sorcha, Clarke, Susan, Gibson, David, McAllister, Catherine and Rooney, Madeleine (2011) Synovial membrane immunohistology in early untreated juvenile idiopathic arthritis: differences between clinical subgroups. Annals of the Rheumatic Diseases, 70. pp. 1842-1850.

Duncan, MW and Gibson, David (2011) Intact Protein Quantification by Mass Spectrometry. In: Mass Spectrometry Applications to the Clinical Lab, San Diego, CA, USA. MSACL, Inc. 281-282

Al-Fadda, A.A., Turjoman, A.A., Newell, K., Gibson, D.S., Lamont, J.V. and Duncan, M.W. (2011) Multiplex determination of analytes related to metabolic syndrome after weight loss with Evidence biochip arrays. In: IFCC WorldLab EuroMedLab, Berlin. De Gruyter. Vol 49 (s1), O385

Gibson, David, Banha, Joao, Penque, Deborah, Costa, Luciana, Conrads, Thomas, Cahill, Delores, O'Brien, John and Rooney, Madeleine (2010) Diagnostic and prognostic biomarker discovery strategies for autoimmune disorders. Journal of Proteomics, 73. pp. 1045-1060.

Duncan, Mark W., Gibson, David S., Bunn Jr, Paul A., Spreafico, Anna, Baron, Anna E, Wagner, Brandie, Miller, York E., Toner, Vicki, McConnell, Ivan, Lamont, John V. and Fitzgerald, Peter S. (2010) Multi-analyte study of circulating cytokines in smokers, with or without chronic obstructive pulmonary disease, and with or without lung cancer, using biochip array technology. In: 8TH Joint Conference of the International Cytokine Society and the International Society for Interferon and Cytokine Research, Cytokines in infectious diseases, autoimmune disorders and cancer, Chicago, IL, USA. Elsevier Ltd.. Vol 52 (1-2), 95

Nowelsky, E.A., Morrissey, J.K., Gibson, D.S., Harris, P.A. and Staniar, W.B. (2010) Proteomic analysis of synovial fluid and plasma from horses fed a high or low starch diet.. In: American Society of Animal Science Joint Annual Meeting, Denver, Colorado. American Society of Animal Science. Vol 88 (s2), 762

Gibson, David, Finnegan, Sorcha, Jordan, Grant, Scaife, Caitriona, Brockbank, Simon, Curry, Jim, McAllister, Catherine, Pennington, Stephen, Dunn, Michael and Rooney, Madeleine (2009) Stratification and Monitoring of Juvenile Idiopathic Arthritis Patientsby Synovial Proteome Analysis. Journal of Proteome Research, 8 (12). pp. 5601-5609.

Low, J.M., Chauhan, A.K., Gibson, D.S., Zhu, M., Chen, S., Rooney, M.E., Ombrello, M.J. and Moore, T.L. (2009) Proteomic analysis of circulating immune complexes in juvenile idiopathic arthritis reveals disease-associated proteins. Proteomics Clinical Applications, 3 (7). pp. 829-840.

Gibson, David, Blelock, Sarah, Curry, Jim, Finnegan, Sorcha, Healy, Adrienne, Scaife, Caitriona, McAllister, Catherine, Pennington, Stephen, Dunn, Michael and Rooney, Madeleine (2009) Comparative analysis of synovial fluid and plasma proteomes in juvenile arthritis – Proteomic patterns of joint inflammation in early stage disease. Journal of Proteomics, 72. pp. 656-876.

Gibson, D.S., Rooney, M.E., Rosenkranz, M.E., Hirsch, R., Scaife, C. and Pennington, S. (2008) Validation of JIA Patient Stratification by Synovial Proteome Profiles in an Independent Cohort. In: American College of Rheumatology Annual Scientific Meeting, San Francisco, California. Wiley. (138)

Blelock, Sarah, Gibson, David, Clarke, Susan, McAllister, Catherine, Jordan, Grant and Rooney, Madeleine (2008) The role of growth factors and osteoclast mediators in the pathogenesis of early untreated juvenile idiopathic arthritis (JIA). In: British Society for Rheumatology, Liverpool. Oxford Journals. Vol 47 (Suppl), ii4

Pascoli, Laura, Blelock, Sarah, McAllister, Catherine, Clarke, Susan, Gibson, David and Rooney, Madeleine (2008) Juvenile idiopathic arthritis: Synovial predictors of outcome. In: British Society for Rheumatology, Liverpool. Oxford Journals. Vol 47 (Suppl), ii26

Gibson, David, Bramwell, David and Scaife, Catriona (2008) Difference In-Gel Electrophoresis: A High-Resolution Protein Biomarker Research Tool. In: Biomarker Methods in Drug Discovery and Development. Humana Press, USA, pp. 189-209. ISBN 978-1-934115-23-7

Gibson, David, Blelock, Sarah, Curry, Jim, Finnegan, Sorcha, Healy, Adrienne, Scaife, Catriona, McAllister, Catherine, Pennington, Stephen, Dunn, Michael and Rooney, Madeleine (2008) Synovial fluid proteome expression patterns segregate juvenile idiopathic arthritis patients. In: British Society for Rheumatology, Liverpool. Oxford Journals. Vol 47 (Suppl), ii27

Gibson, David S. and Rooney, Madeleine E. (2007) The human synovial fluid proteome: A key factor in the pathology of joint disease. Proteomics Clinical Applications, 1 (8). pp. 889-899.

Gibson, David S., Blelock, Sarah, Brockbank, Simon, Curry, Jim, Healy, Adrienne, McAllister, Catherine and Rooney, Madeleine E. (2006) Proteomic analysis of recurrent joint inflammation in juvenile idiopathic arthritis.. Journal of Proteome Research, 5 (8). pp. 1988-1995.

Farrell, S., McMaster, C., Gibson, D., Shields, M.D. and McCallion, W.A. (2006) Pepsin in bronchoalveolar lavage fluid: a specific and sensitive method of diagnosing gastro-oesophageal reflux-related pulmonary aspiration.. Journal of Pediatric Surgery, 41 (2). pp. 289-293.

Gardiner, Tom A., Gibson, David S., de Gooyer, Tanyth E., de la Cruz, Vidal F., McDonald, Denise M. and Stitt, Alan W. (2005) Inhibition of tumor necrosis factor-alpha improves physiological angiogenesis and reduces pathological neovascularization in ischemic retinopathy. American Journal of Pathlogy, 166 (2). pp. 637-644.

Gibson, David, Blelock, Sarah, Brockbank, Simon, Curry, Jim, Healy, Adrienne, McAllister, Catherine and Rooney, Madeleine (2005) Proteomic identification of a biomarker cluster associated with recurrent joint inflammation in Juvenile Idiopathic Arthritis. In: Irish Society for Rheumatology and Irish Rheumatology Health Professionals Society, Annual General Meeting, Trinity Centre St. Jamess Hospital Dublin 8. Springer. Vol 174 (4 (es5), 1-54

Curry, William James, Brockbank, Simon, McCollum, Anna Patricia, Boyle, Cliona and Gibson, David (2003) Localisation of WE-14 immunoreactivity in the developing mouse limbo-corneal nerve net. Microscopy Research and Technique, 62 (5). pp. 408-414.

Gibson, D.S., Stitt, A.W. and Gardiner, T.A. (2003) Cytokine Inhibition Reduces Intra-retinal Angiogenesis but Increases Extra-retinal Neovascularisation in Oxygen-induced Retinopathy. In: The Association for Research in Vision and Ophthalmology Annual Scientific Meeting, Fort Lauderdale, Florida. Lippincott Williams & Wilkins. Vol 44 (5), 2917

Flannery, Thomas, Gibson, David, Mirakur, Menakshi, McQuaid, Stephen, Greenan, Caroline, Anne, Trimble, Walker, Brian, McCormick, Derek and Johnston, Patrick G. (2003) The clinical significance of cathepsin S expression in human astrocytomas. American Journal of Pathlogy, 163 (1). pp. 175-182.

Gibson, David, Flannery, Thomas, Mulligan, Karl, Mirakhur, M and McCormick, Derek (2002) The role of the cysteine proteinase cathepsin S in astrocytoma invasion. In: 102nd Meeting of the British Neuropathological Society, Institute of Child Health, London. Blackwell Science Ltd. Vol 28 156

This list was generated on Sat Jun 24 13:16:08 2017 BST.