Gibson, David Dr
Lecturer in Stratified Medicine
Academic and Professional Qualifications
2012 Good Clinical Practice training, Ashford and St. Peter’s Hospitals NHS Trust, UK
2007 Fellow of the Higher Education Academy
2006 Postgraduate Certificate in Higher Education Teaching, Queen’s University Belfast
2005 E-tutor Certificate, Campus One, University of Ulster
2002 NILTG for Animal Scientific Procedures Certificate (Personal License)
2001 PhD Oncology, CCRCB, Queen’s University of Belfast
1995 BSc Hons Biochemistry, Queen’s University of Belfast
After his Biochemistry degree, Dr David Gibson worked at Randox Laboratories Ltd, where he was responsible for designing and commercializing novel biochip array diagnostic tests. He was awarded a Ph.D. in 2001 from the Centre for Cancer Research and Cell Biology, Queen’s University Belfast, for research which exposed the role of cysteine proteinases in brain tumour invasion. During a Wellcome Trust Fellowship Dr Gibson investigated the role of inflammation in a hypoxia driven model of diabetic retinopathy at the Centre of Vision and Vascular Science, QUB.
Since 2003 Dr Gibson focused his research efforts on the discovery and validation of protein biomarkers which could improve the management of arthritis patients. During his time at the Rooney laboratory in the Centre of Infection and Immunity, QUB he spearheaded the use of proteomic and bioinformatic strategies to identify a plasma and synovial fluid protein ‘fingerprint’ that predicts disease spread in children with arthritis. He also identified post translational modifications in the Vitamin D binding protein that may act as a modulator of inflammation in juvenile arthritis patients.
In 2009, Dr Gibson was awarded a prestigious travel fellowship from Arthritis Research UK to conduct research at the Duncan laboratory at the University of Colorado, Denver over two years. From this fellowship Dr Gibson brings expertise in mass spectrometry analyses of clinically relevant proteins, peptides and post-translational modifications to his current post at the University of Ulster.
Stratified Medicine- ‘the right treatment, for the right person, at the right time’
In 2013 Dr Gibson took up his post as Lecturer in Stratified Medicine and his research is focused on adult rheumatoid arthritis (RA). He is particularly interested in the development of new prognostic and predictive tools to improve the clinical management of arthritis patients. David’s current research within the Northern Ireland Centre for Stratified Medicine is based at C-TRIC within the Altnagelvin Hospital campus, Londonderry.
He employs novel mass spectrometry based methods to robustly identify and quantify disease associated proteins. These methods are useful to investigate the role of protein modification in arthritis, as a surrogate measure of inflammatory activity. He is also interested in the application of protein array technologies for autoantibody screening. He will initially establish research programmes in three key areas: 1. How RA patients develop resistance to biologic therapies. 2. How inflammation and joint destruction can persist without clinical symptoms. 3. Can alternate methods of blood sampling support patient care away from the hospital clinic. Ultimately, Dr Gibson will develop novel monitoring tools to help clinicians target those patients who do not respond well to current therapeutics or develop drug resistance over time. This would allow earlier more effective treatments in RA patients, thus preventing joint damage and reducing disability.
Teaching & Learning Activities
1. Inflammatory and Immunological Disease,
2. Genetic Inheritance/ Genomics, Proteomics and Metabolomics,
3. In Silico Genomic, Proteomic and Metabolomic analysis methods.
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Gibson, David Dr
Dr David Gibson
School of Biomedical Sciences