Holscher, Christian Dr
Senior Lecturer in Neurobiology
Academic and Professional Qualifications
1989: BA Biology and Biochemistry, University of Kiel, Germany
1990: MSc Neurobiology, University of Tubingen, Dept. of Neuropharmacology, Germany
1994: PhD Neuroscience, Open University Biology Dept, UK.
2002: Faculty Member, Faculty of Biology (Habilitation)
Career History
2004- present: Lecturer in Neurobiology, University of Ulster
2000-2004: Assistant Professorship, University of Tubingen, Germany
1999-2000: MRC Research Fellowship in Neuroscience, University of Oxford
1997-1999: Temporary Lectureship in Physiology, University College Dublin
1995-1997: Human Capital and Mobility Fellowship, Trinity College
Holscher, Christian Dr
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Dr Christian Holscher |
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Room W1083 |
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Email: c.holscher@ulster.ac.uk
Holscher, Christian Dr - Publications
Porter, DW, Flatt, Peter, Holscher, Christian and Gault, Victor (2013) Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice.. International Journal of Obesity, 37 (5). pp. 678-684.
Porter, David, Faivre, Emilie, Flatt, Peter, Holscher, Christian and Gault, Victor (2012) Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice. PEPTIDES, 35 (1). pp. 1-8.
Gengler, Simon, McClean, Paula L., McCurtin, Ruth, Gault, Victor and Holscher, Christian (2012) Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. NEUROBIOLOGY OF AGING, 33 (2). pp. 265-276.
McClean, Paula, Parthsarathy, Vadivel, Faivre, Emilie and Holscher, Christian (2011) The diabetes drug Liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. . The Journal of Neuroscience, 31 (17). pp. 6587-6594.
McClean, P. L., Parthasarathy, V., Gault, Victor and Holscher, Christian (2011) LIRAGLUTIDE, A NOVEL GLP-1 ANALOGUE, PREVENTS THE IMPAIRMENT OF LEARNING AND LTP AND PLAQUE FORMATION IN AN APP/PS-1 MOUSE MODEL OF ALZHEIMER'S DISEASE. IRISH JOURNAL OF MEDICAL SCIENCE, 180 (2). pp. 18.
Hamilton, Alison, Patterson, Steven, porter, David, Gault, Victor A and Holscher, Christian (2011) Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain. J Neurosci Res, 89. pp. 481-489.
faivre, Emilie, Gault, Victor, thorens, Bernard and Holscher, Christian (2011) Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis. J Neurophysiol, 89. pp. 481-489.
Holscher, Christian (2011) Protective roles of the incretin hormones Glucagon-Like Peptide-1 and Glucose-dependent Insolinotropic Polypeptide hormones in neurodegeneration. In: Alzheimer's disease. InTech publishing, pp. 123-184. ISBN ISBN 978-953-307-466-5
Jalewa, Jaishree, Wong-Lin, KongFatt, McGinnity, Martin and Holscher, Christian (2011) Mapping out the receptors of serotonin and orexin between the dorsal raphe nucleus and the lateral hypothalamus and their possible circuit dynamics in a mouse model of depression. In: Society for Neuroscience, 2011, Washington, DC. Society for Neuroscience.
Porter, D. W., Kerr, B. D., Flatt, Peter, Holscher, Christian and Gault, Victor (2010) Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance. DIABETES OBESITY & METABOLISM, 12 (10). pp. 891-899.
McClean, Paula, Parthsarathy, V., Faivre, E. and Holscher, Christian (2010) The novel GLP-1 analogue liraglutide has neuroprotective properties in a mouse model of Alzheimer's disease. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 40.
Irwin, Nigel, Porter, W. D., Flatt, Peter, Holscher, Christian and Gault, Victor (2010) Prolonged GIP receptor activation improves glucose homeostasis and cognitive function in high-fat fed mice. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 44.
Porter, W. D., Kerr, B. D., Flatt, Peter, Holscher, Christian and Gault, Victor (2010) The glucagon-like peptide-1 agonist Liraglutide improves memory and learning in obese-diabetic mice. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 40.
Gault, Victor, Porter, W. D., Flatt, Peter and Holscher, Christian (2010) Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet. INTERNATIONAL JOURNAL OF OBESITY, 34 (8). pp. 1341-1344.
McClean, Paula, Gault, Victor A, Harriott, Patrick and Holscher, Christian (2010) Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease. EUROPEAN JOURNAL OF PHARMACOLOGY, 630 (1-3). pp. 158-162.
Porter, David, Irwin, Nigel, Flatt, Peter, Holscher, Christian and Gault, Victor (2010) Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high fat fed mice. Eur J Pharmacol, 650. pp. 688-693.
Wang, xiao-Hui, li, Lin, Holscher, Christian, Pan, Yan-Fang, Chen, Xiao-Rong and Qi, Jin-Shun (2010) Val8-GLP-1 Protects Against Aß1-40-Induced Impairment of Hippocampal Late-Phase Long-Term Potentiation and Spatial Learning in Rats. . Neuroscience, 170. pp. 1239-1248.
Gengler, Simon, Hamilton, Alison and Holscher, Christian (2010) Synaptic plasticity in the hippocampus of a APP/PS1 mouse model of Alzheimer’s disease is impaired in old but not young mice. PLoS ONE, 000.
Fendt, M, Bürki, H, Imobersteg, S, van der Putten, H, McAllister, K, Leslie, Julian, Shaw, D and Holscher, Christian (2010) The effect of mGlu(8) deficiency in animal models of psychiatric diseases.. Genes, brain, and behavior, 9. pp. 33-44.
Holscher, Christian and Li, Lin (2010) New roles for insulin-like hormones in neuronal signalling and protection: new hopes for novel treatments of Alzheimer’s Disease?. Neurobiol Aging, 31 (9). pp. 1495-1502.
Holscher, Christian (2010) Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease. Recent Patents on CNS Drug Discovery, 5. pp. 109-117.
Holscher, Christian (2010) Höhere Verarbeitungsprozesse. In: Taschenlehrbuch Biologie, Zoologie. Thieme Verlag, pp. 551-584. ISBN ISBN 978-3-13-144841-5
Holscher, Christian (2010) The role of GLP-1 in neuronal activity and neurodegeneration. In: Vitamins and Hormones: INCRETINS AND INSULIN SECRETION. Academic Press/Elsevier, pp. 331-354. ISBN ISBN: 978-0-12-381517-0
Gengler, Simon, McClean, Paula, McCurtin, Ruth, Gault, Victor and Holscher, Christian (2010) Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. Neurobiol Aging, 000. pp. 000-000.
Holscher, Christian, Fung, K., McCurtin, R., Gault, Victor and McClean, Paula (2009) Novel GLP-1 analogues cross the blood brain barrier and enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease. DIABETOLOGIA, 52 (Suppl. 1). pp. 790.
Hamilton, Alison and Holscher, Christian (2009) Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system. Neuroreport, 20. pp. 1161-1166.
McClean, Paula, Gault, Victor, Harriott, Patrick and Holscher, Christian (2009) Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease.. European journal of pharmacology, epub.
Li, Lin, Li, Yan-wei, Zhao, Jin-ying, Liu, Yue-Ze and Holscher, Christian (2009) Quantitative analysis of iron concentration and expression of ferroportin 1 in the cortex and hippocampus of rats induced by cerebral ischemia.. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 16 (11). pp. 1466-72.
Wang, Hongjuan, Wang, Rong, Zhao, Zhiwei, Ji, Zhijuan, Xu, Shiming, Holscher, Christian and Sheng, Shuli (2009) Coexistences of insulin signaling-related proteins and choline acetyltransferase in neurons.. Brain research, 1249. pp. 237-43.
Abbas, Talib, Faivre, Emilie and Holscher, Christian (2009) Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease.. Behavioural brain research, 205 (1). pp. 265-71.
Holscher, Christian, van Aalten, Lidy and Sutherland, Calum (2008) Anaesthesia generates neuronal insulin resistance by inducing hypothermia.. BMC neuroscience, 9. pp. 100.
Holscher, Christian and Li, Lin (2008) New roles for insulin-like hormones in neuronal signalling and protection: New hopes for novel treatments of Alzheimer's disease?. Neurobiology of Aging, epub.
Gault, Victor A and Holscher, Christian (2008) Protease-resistant glucose-dependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid.. Journal of neurophysiology, 99 (4). pp. 1590-5.
Gault, Victor and Holscher, Christian (2008) GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid.. European journal of pharmacology, 587 (1-3). pp. 112-7.
Holscher, Christian (2008) Functional roles of Theta and Gamma oscillations in the association and dissociation of neuronal networks in primates and rodents. In: Information Processing by Neuronal Populations. (Eds: Holscher, Christian and Munk, M), Cambridge University Press, pp. 151-173. ISBN ISBN 978-0-521-87303-1
Holscher, Christian (2008) How could populations of neurons encode information?. In: Information Processing by Neuronal Populations. (Eds: Holscher, Christian and Munk, M), Cambridge University Press, pp. 3-20. ISBN ISBN 978-0-521-87303-1
Holscher, Christian and Munk, M, eds. (2008) Mechanisms of information processing in the Brain: Information Processing by Neuronal Population. 666 pp. Cambridge University Press. ISBN ISBN 978-0-521-87303-1
Gengler, Simon, Gault, Victor, Harriott, Patrick and Holscher, Christian (2007) Impairments of hippocampal synaptic plasticity induced by aggregated beta-amyloid (25-35) are dependent on stimulation-protocol and genetic background. EXPERIMENTAL BRAIN RESEARCH, 179 (4). pp. 621-630.
Li, Lin and Holscher, Christian (2007) Common pathological processes in Alzheimer disease and type 2 diabetes: a review.. Brain research reviews, 56 (2). pp. 384-402.
Holscher, Christian, Gengler, S, Gault, Victor, Harriott, P and Mallot, HA (2007) Soluble beta-amyloid[25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning. European Journal of Pharmacology , 561. pp. 85-90.
Gengler, Simon, Gault, Victor, Harriott, Peter and Holscher, Christian (2007) Beta-amyloid (25-35) induced impairments of hippocampal synaptic plasticity are dependent on stimulation-protocol, genetic background, and aggregation state. Exp Brain Res, 179. pp. 621-632.
Radde, R, Bolmont, T, Käser, SA, Coomaraswamy, J, Lindau, D, Stoltze, L, Calhoun, ME, Jäggi, F, Wolburg, H, Gengler, S, Haass, C, Ghetti, B, Czech, C, Holscher, Christian, Mathews, PM and Jucker, M (2006) Aß42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Reports, 7. pp. 940-946.
Holscher, Christian, Schmid, S, Pilz, P, van der Putten, H and Plappert, C (2005) Lack of the metabotropic glutamate receptor subtype 7 selectively modulates theta rhythm and working memory. Learning and Memory, 12. pp. 450-455.
Holscher, Christian (2005) Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies. Reviews in the Neurosciences, 16. pp. 181-212.
