School of Biomedical Sciences

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Howard, Vyvyan Professor

Professor of Bioimaging

Academic and Professional Qualifications

- 1970 MB ChB, Liverpool
- 1983 Ph D, Liverpool
- 1995 MRCPath
- 1999 FRCPath

Career History

- 1991 - Senior Lecturer, Developmental Toxico-Pathology, University of Liverpool
- 1975 - 1991 Lecturer in Anatomy, University of Liverpool
- 1971 - 1975 Demonstrator in Anatomy, University of Liverpool
- 1970 - 1971 House Officer, Sefton General Hospital, Liverpool

Teaching & Learning Activities

Professor Vyvyan Howard is a medically-qualified toxico-pathologist and the leader of the Bioimaging Research Group (BRG). He has held the Presidencies of the Royal Microscopical Society and the International Society for Stereology and was the General Editor of the Journal of Microscopy from 1985-91, the period when both confocal and scanning probe microscopy were becoming established. He is co-author of "Unbiased Stereology" the main textbook for the application to 3D measurement in microscopy, otherwise termed stereology, a field in which he has contributed and published widely.

In recent years, he has become involved in researching the toxicological properties of particles, in particular, nano-particles. These fall into the size range of 1 to 100 nanometres and therefore the use of high resolution microscopy (such as that available within the BRG) for their detection is mandatory. The BRG is involved in a number of projects investigating nano-particle fate in living systems.

Research Interests

In recent years, he has become involved in researching the toxicological properties of particles, in particular, nano-particles. These fall into the size range of 1 to 100 nanometres and therefore the use of high resolution microscopy (such as that available within the BRG) for their detection is mandatory. The NSB is involved in a number of projects investigating nano-particle fate in living systems.

Brief profile

Vyvyan Howard is Professor of Bioimaging, a medically-qualified toxico-pathologist and the current leader of the Nano Systems Research Group. He has held the Presidencies of the Royal Microscopical Society and the International Society for Stereology and was the General Editor of the Journal of Microscopy from 1985-91, the period when both confocal and scanning probe microscopy were becoming established. He is co-author of “Unbiased Stereology†the main textbook for the application to 3D measurement in microscopy, otherwise termed stereology, a field in which he has contributed and published widely. From 2007 to 2009 he was the President of the International Society of Doctors for the Environment, an organisation representing some 30,000 medical doctors around the world which has WHO and UN recognition. He served on the DEFRA Advisory Committee on Pesticides from 2002-2008 as a toxicologist.

Howard, Vyvyan Professor

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phone:
Email: v.howard@ulster.ac.uk

Howard, Vyvyan Professor - Publications

Number of items: 40.

Barnes, Clifford, McKerr, George, Soto, A. M., Downes, Stephen and Howard, Vyvyan (2014) From Single Cells to Tissues: Interactions between the Matrix and Human Breast Cells in Real Time. PLOS ONE, 9 (4). pp. 1-12.

Van Hoecke, K., De Schamphelaere, K. A. C., Ali, Z., Zhang, F., Elsaesser, A., Rivera-Gil, P., Parak, W. J., Smagghe, G., Howard, Vyvyan and Janssen, C. R. (2013) Ecotoxicity and uptake of polymer coated gold nanoparticles. Nanotoxicology, 7 (1). pp. 37.

Park, Margriet V. D. Z., Verharen, Henny W., Zwart, Edwin, Hernandez, Lya G., van Benthem, Jan, Elsaesser, Andreas, Barnes, Clifford, McKerr, George, Howard, Vyvyan, Salvati, Anna, Lynch, Iseult, Dawson, Kenneth A. and de Jong, Wim H. (2011) Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmidlacZgene mutation assay. Nanotoxicology, 5 (2). pp. 168-181.

Hazekamp, J, Doherty, S, Elsaesser, A, Barnes, Clifford, O'Hagan, Barry, McKerr, George and Howard, Vyvyan (2011) Focussed ion beam milling at grazing incidence angles.. Journal of microscopy, 242 (1). pp. 104-10.

Elsaesser, Andreas, Barnes, Clifford A, McKerr, George, Salvati, Anna, Lynch, Iseult, Dawson, Kenneth A and Howard, Vyvyan (2011) Quantification of nanoparticle uptake by cells using an unbiased sampling method and electron microscopy.. Nanomedicine (London, England), 6 (7). pp. 1189-98.

McArt, DG, McKerr, George, Saetzler, Kurt, Howard, Vyvyan, Downes, Stephen and Wasson, GR (2010) Comet sensitivity in assessing DNA damage and repair in different cell cycle stages. Mutagenesis, 25 (3). pp. 299.

Elsaesser, Andreas, Taylor, Ashley, Staats, Gesa, McKerr, George, Kim, Eun-Mee, O’Hare, Eugene and Howard, Vyvyan (2010) Quantification of nanoparticle uptake by cells using microscopical and analytical techniques. Nanomedicine, 5 (9). pp. 1447-1457.

Park, Margriet VDZ, Annema, Wijtske, Salvati, Anna, Lesniak, Anna, Elsaesser, Andreas, Barnes, Clifford, McKerr, George, Howard, Vyvyan, Lynch, Iseult, Dawson, Kenneth A, Piersma, Aldert H and de Jong, Wim H (2009) In vitro developmental toxicity test detects inhibition of stem cell differentiation by silica nanoparticles. TOXICOLOGY AND APPLIED PHARMACOLOGY, 240 (1). pp. 108-116.

Van Hoecke, Karen, Quik, Joris TK, Mankiewicz-Boczek, Joanna , De Schamphelaere, Karel AC, Elsaesser, Andreas, Van der Meeren, Paul, Barnes, Clifford, McKerr, George, Howard, Vyvyan, Van De Meent, Dik, Rydznyski, Konrad, Dawson, Kenneth, Salvati, Anna, Lynch, Iseult, Silversmit, Geert, De Samber, Bjorn , Vincze, Laszlo and Janssen, Colin R (2009) Fate and Effects of CeO2 Nanoparticles in Aquatic Ecotoxicity Tests. Environmental Science Technology, 43 (12). pp. 4537-4546.

McArt, Darragh G, McKerr, G, Howard, Vyvyan, Saetzler, Kurt and Wasson, Gillian R (2009) Modelling the comet assay. Biochemical Society Transactions, 037 (4). pp. 914-917.

McArt, Darragh G, Wasson, Gillian R, McKerr, George, Saetzler, Kurt, Reed, Matt and Howard, Vyvyan (2009) Systematic random sampling of the comet assay. Mutagenesis, 24 (4). pp. 373-378.

Myllynen, Paivi K., Loughran, Michael J., Howard, Vyvyan, Sormunen, Raija, Walsh, Adrian A. and Vahakangas, Kirsi H. (2008) Kinetics of gold nanoparticles in the human placenta. REPRODUCTIVE TOXICOLOGY, 26 (2). pp. 130-137.

Sneddon, Jennifer C., Ritruechai, Pattama, de Yanes, Gesa Staats and Howard, Vyvyan (2008) Seasonal influences on quantitative changes in sweat-associated anatomy in native and thoroughbred horses. VETERINARY DERMATOLOGY, 19 (3). pp. 163-173.

Barnes, Clifford, Elsaesser, Andreas, Arkusz, Joanna, Smok, Anna, Palus, Jadwiga, Leśniak, Anna, Salvati, Anna, Hanrahan, John P., Jong, Wim H. de, Dziubałtowska, Elżbieta, Stȩpnik, Maciej, Rydzyński, Konrad, McKerr, George, Lynch, Iseult, Dawson, Kenneth A. and Howard, Vyvyan (2008) Reproducible Comet Assay of Amorphous Silica Nanoparticles Detects No Genotoxicity. Nano Letters, 8 (9). pp. 3069.

Newby, J. A., Busby, C. C., Howard, Vyvyan and Platt, M. J. (2007) The cancer incidence temporality index: An index to show temporal changes in the age of onset of overall and specific cancer (England and Wales, 1971-1999). BIOMEDICINE & PHARMACOTHERAPY, 61 (10). pp. 623-630.

Ellis, Kathryn A., Monteiro, Ana, Innocent, Giles T., Grove-White, Dai, Cripps, Peter, McLean, W. Graham, Howard, Vyvyan and Mihmz, Monika (2007) Investigation of the vitamins A and E and beta-carotene content in milk from UK organic and conventional dairy farms. JOURNAL OF DAIRY RESEARCH, 74 (4). pp. 484-491.

Ellis, Kathryn A., Innocent, Giles T., Mihm, Monika, Cripps, Peter, McLean, W. Graham, Howard, Vyvyan and Grove-White, Dai (2007) Dairy cow cleanliness and milk quality on organic and conventional farms in the UK. JOURNAL OF DAIRY RESEARCH, 74 (3). pp. 302-310.

Barnes, Clifford, O'Hagan, Barry, Howard, Vyvyan and McKerr, G (2007) Verification of cell viability at progressively higher scanning forces using a hybrid atomic force and fluorescence microscope.. Journal of microscopy, 228 (Pt 2). pp. 185-9.

Kannekens, EM, Murray, RD, Howard, Vyvyan and Currie, J (2006) A stereological method for estimating the feto-maternal exchange surface area in the bovine placentome at 135 days gestation. RESEARCH IN VETERINARY SCIENCE, 81 (1). pp. 127-133.

Ellis, KA, Innocent, G, Grove-White, D, Cripps, P, McLean, WG, Howard, CV and Mihm, M (2006) Comparing the fatty acid composition of organic and conventional milk. JOURNAL OF DAIRY SCIENCE, 89 (6). pp. 1938-1950.

Lau, K, McLean, WG, Williams, DP and Howard, Vyvyan (2006) Synergistic interactions between commonly used food additives in a developmental neurotoxicity test. TOXICOLOGICAL SCIENCES, 90 (1). pp. 178-187.

Sneddon, JC, Boomker, E and Howard, Vyvyan (2006) Mucosal surface area and fermentation activity in the hind gut of hydrated and chronically dehydrated working donkeys. JOURNAL OF ANIMAL SCIENCE, 84 (1). pp. 119-124.

Cranston, A, Howard, L and Howard, Vyvyan (2004) Quantitative phenotyping as an efficient means to estimate C-cell number in a knock-in mouse model of MEN2B. TRANSGENIC RESEARCH, 13 (4). pp. 339-348.

Pennycook, FR, Diamand, EM, Watterson, A and Howard, Vyvyan (2004) Modeling the dietary pesticide exposures of young children. INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 10 (3). pp. 304-309.

Hill, A, Howard, Vyvyan, Strahle, U and Cossins, A (2003) Neurodevelopmental defects in zebrafish (Danio rerio) at environmentally relevant dioxin (TCDD) concentrations. TOXICOLOGICAL SCIENCES, 76 (2). pp. 392-399.

Axelrad, JC, Howard, Vyvyan and McLean, WG (2003) The effects of acute pesticide exposure on neuroblastoma cells chronically exposed to diazinon. TOXICOLOGY, 185 (1-2). pp. 67-78.

Dhaliwal, GS, Murray, RD, Rees, EM, Howard, Vyvyan and Beech, DJ (2002) Quantitative unbiased estimates of endometrial gland surface area and volume in cycling cows and heifers. RESEARCH IN VETERINARY SCIENCE, 73 (3). pp. 259-265.

Kelsall, A, Fitzgerald, AJ, Howard, Vyvyan, Evans, RC, Singh, R, Rhodes, JM and Goodlad, RA (2002) Dietary lectins can stimulate pancreatic growth in the rat. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 83 (4). pp. 203-208.

Hill, AJ, Howard, Vyvyan and Cossins, AR (2002) Efficient embedding technique for preparing small specimens for stereological volume estimation: zebrafish larvae. JOURNAL OF MICROSCOPY-OXFORD, 206 (Part 3). pp. 179-181.

Axelrad, JC, Howard, Vyvyan and McLean, WG (2002) Interactions between pesticides and components of pesticide formulations in an in vitro neurotoxicity test. TOXICOLOGY, 173 (3). pp. 259-268.

Platt, MJ, Stanisstreet, M, Casson, IF, Howard, Vyvyan, Walkinshaw, S, Pennycook, S and McKendrick, O (2002) St Vincent's Declaration 10 years on: outcomes of diabetic pregnancies. DIABETIC MEDICINE, 19 (3). pp. 216-220.

Reed, MG, Shanks, E, Beech, DJ, Barlow, L and Howard, Vyvyan (2001) Stereological estimation of eye volume using the Pappus method. JOURNAL OF MICROSCOPY-OXFORD, 202 (Part 3). pp. 473-479.

Ansari, T, Sibbons, PD and Howard, Vyvyan (2001) Estimation of mean nuclear volume of neocortical neurons in sudden infant death syndrome cases using the nucleator estimator technique. BIOLOGY OF THE NEONATE, 80 (1). pp. 48-52.

Beech, DJ, Sibbons, PD, Howard, Vyvyan and van Velzen, D (2000) Terminal bronchiolar duct ending number does not increase post-natally in normal infants. EARLY HUMAN DEVELOPMENT, 59 (3). pp. 193-200.

Beech, DJ, Sibbons, PD, Howard, Vyvyan and van Velzen, D (2000) Renal developmental delay expressed by reduced glomerular number and its association with growth retardation in victims of sudden infant death syndrome and in ``normal'' infants. PEDIATRIC AND DEVELOPMENTAL PATHOLOGY, 3 (5). pp. 450-454.

Beech, DJ, Howard, Vyvyan, Reed, MG, Sibbons, PD and Van Velzen, D (2000) Unbiased and efficient estimation of the total number of terminal bronchiolar duct endings in lung: a modified physical disector. JOURNAL OF MICROSCOPY-OXFORD, 197 (Part 1). pp. 36-45.

Howard, Vyvyan and Saunders, PT (1999) Sensible precautions make good science .... NATURE, 401 (6750). pp. 207.

Reed, MG and Howard, Vyvyan (1999) Stereological estimation of covariance using linear dipole probes. JOURNAL OF MICROSCOPY-OXFORD, 195 (Part 2). pp. 96-103.

Brotchie, D, Birch, M, Roberts, N, Howard, Vyvyan, Smith, VA and Grierson, I (1999) Localisation of connective tissue and inhibition of autofluorescence in the human optic nerve and nerve head using a modified picrosirius red technique and confocal microscopy. JOURNAL OF NEUROSCIENCE METHODS, 87 (1). pp. 77-85.

Norton, TA, Thompson, RC, Pope, J, Veltkamp, CJ, Banks, B, Howard, Vyvyan and Hawkins, SJ (1998) Using confocal laser scanning microscopy, scanning electron microscopy and phase contrast light microscopy to examine marine biofilms. AQUATIC MICROBIAL ECOLOGY, 16 (2). pp. 199-204.

This list was generated on Thu Oct 30 12:09:41 2014 GMT.