Biomedical Sciences

Skip Navigation |

  1. Background
  2. Contact
  3. Publications

McKenna, Declan Dr

Lecturer in Haematology

Academic and Professional Qualifications

- 1999 Ph.D. Biochemistry & Molecular Biology, Queen’s University, Belfast

- 1996 BSc (Hons) Biochemistry, Class 2.1, Queen’s University, Belfast

- 2007 Postgraduate Certificate in Higher Education Practice, University of Ulster

Career History

- 2011 Lecturer in Haematology, University of Ulster

- 2008-2011 Research Fellow in Cancer Research, Queen’s University, Belfast

- 2002-2011 E-tutor in Biomedical Sciences, University of Ulster

- 2005-2008 Research Fellow in Molecular Biosciences, University of Ulster

- 2002-2005 Research Associate in Cancer & Ageing, University of Ulster

- 1999-2002 Research Officer in Cancer & Ageing, University of Ulster

Teaching & Learning Activities

Subject Areas: Haematology, Transfusion Science, Oncology, Human Molecular Genetics, Public Engagement in Science, BMS DPP Placement Tutor.

Research Interests

Cancer, stem cells, microRNAs, DNA repair, epigenetics. biomed.science.ulster.ac.uk/stemcell

McKenna, Declan Dr

space

Dr Declan McKenna
Lecturer in Haematology
Biomedical Sciences Research Institute

space

Room W1043
School of Biomedical Sciences
University of Ulster
Coleraine campus
Cromore Road
Coleraine
Co. Londonderry
BT52 1SA

phone: +44 28 70124356
Email: dj.mckenna@ulster.ac.uk

McKenna, Declan Dr - Publications

Number of items: 32.

Byrne, NM, Nesbitt, Heather, Ming, L, McKeown, Stephanie, Worthington, Jenny and McKenna, Declan (2016) Androgen deprivation in LNCaP prostate tumour xenografts induces vascular changes and hypoxic stress, resulting in promotion of epithelial-to-mesenchymal transition. British Journal of Cancer, epub.

Lynch, Seodhna M, McKenna, Michael M, Walsh, Colum and McKenna, Declan J (2016) miR-24 regulates CDKN1B/p27 expression in prostate cancer.. The Prostate, epub. pp. .

Lynch, Seodhna, McKenna, Michael, Walsh, Colum and McKenna, Declan (2015) miR-24 regulates p27 expression in prostate cancer. Ulster Medical Journal, 84 (3). pp. 208-209.

Nesbitt, Heather, byrne, niall, Worthington, Jenny, McKeown, Stephanie and McKenna, Declan (2015) Targeting hypoxia in prostate cancer cells to increase treatment efficacy. Ulster Medical Journal, 84 (3). pp. 209-210.

Lynch, Seodhna, mckenna, michael, Walsh, Colum and McKenna, Declan (2015) miR-24 regulates p27 expression in prostate cancer. In: 2015 Keystone Symposia Conference E5: MicroRNAs and Noncoding RNAs in Cancer, Keystone, Colorado. Keystone Symposia.

Lynch, Seodhna, O'Neill, Karla, mckenna, michael, Walsh, Colum and McKenna, Declan (2015) Epigenetic regulation of miR-200c in prostate cancer. In: 2015 Keystone Symposia Conference E5: MicroRNAs and Noncoding RNAs in Cancer, Keystone, Colorado. Keystone Symposia.

Smith, Paul, Wiltshire, Marie, Nesbitt, Heather, Byrne, Niall, Ming, Louise, McKenna, Declan, Worthington, Jenny, McKeown, Stephanie, Patterson, Laurence and Errington, Rachel (2015) Cytometry of Anticancer Prodrug OCT1002 Activation and Targeting Using In Vitro and In Vivo Models of Tumour Hypoxia. In: CYTO 2015, the 30th Congress of the International Society for Advancement of Cytometry, Glasgow,Scotland. International Society for Advancement of Cytometry. 128

O'Donovan, Katie, Nesbitt, Heather, McKeown, Stephanie, Camac, Nicole and McKenna, Declan (2015) Characterization of 22RV1-Luc xenograft response to androgen-deprivation therapy.. In: 2015 Keystone Symposia Conference E3: Hypoxia: From Basic Mechanisms to Therapeutics, Dublin, Ireland. Keystone Symposia.

cochrane, david, o'donovan, katie, Nesbitt, Heather, McKeown, Stephanie, Worthington, Jenny, o'rourke, martin, James, Iain and McKenna, Declan (2015) Characterisation of novel AKT inhibitor in treatment of androgen sensitive prostate cancer. In: Irish Association for Cancer Research 2015, Limerick. Irish Association for Cancer Research.

Nesbitt, Heather, Browne, Gillian, O'Donovan, Katie M., Byrne, Niall M., Worthington, Jenny, McKeown, Stephanie and McKenna, Declan J (2015) Nitric Oxide Up-Regulates RUNX2 in LNCaP Prostate Tumours: Implications for Tumour Growth In Vitro and In Vivo. Journal of Cellular Physiology, 231 (2). pp. 473-482.

Lynch, Seodhna, O'Neill, Karla, McKenna, Michael, Walsh, Colum and McKenna, Declan (2014) Epigenetic Regulation of miRNA expression in prostate cancer. In: 6th Annual Translational Medicine Conference (TMED6 / C-TRIC),, Derry, UK. The Clinical Translational Research and Innovation Centre (C-TRIC). 33-34

Lynch, Seodhna, O'Neill, Karla, mckenna, michael, Walsh, Colum and McKenna, Declan (2014) EPIGENETIC REGULATION OF MICRORNA EXPRESSION IN PROSTATE CANCER. In: RNAi 2014: Short and Long Non-coding RNAs, St Hilda's College, Oxford, UK. Library Publishing Media.

McKenna, Declan J, Patel, Daksha and McCance, Dennis J. (2013) miR-24 and miR-205 expression is dependent on HPV onco-protein expression in keratinocytes. Virology, 448. pp. 210-216.

McKenna, Declan J, Doherty, Bernadette, Downes, Stephen, McKeown, SR and McKelvey-Martin, Valerie J (2012) Use of the Comet-FISH Assay to Compare DNA Damage and Repair in p53 and hTERT Genes following Ionizing Radiation. PLoS ONE, 7 (11). pp. e49364.

Watson, Jenny A, McKenna, Declan J, Maxwell, Perry, Diamond, James, Arthur, Ken, McKelvey-Martin, Valerie J and Hamilton, Peter W (2010) Hyperacetylation in prostate cancer induces cell cycle aberrations, chromatin reorganization and altered gene expression profiles. Journal of Cellular and Molecular Medicine, 14 (6b). pp. 1668-1682.

McKenna, DJ, McDade, SS, Patel, D and McCance, DJ (2010) MicroRNA 203 Expression in Keratinocytes Is Dependent on Regulation of p53 Levels by E6. Journal of Virology, 84 (20). pp. 10644.

Watson, Jenny A, McKenna, Declan J, Maxwell, Perry, Diamond, James, Arthur, Ken, McKelvey-Martin, Valerie J and Hamilton, Peter W (2009) Hyperacetylation in prostate cancer induces cell cycle aberrations, chromatin reorganization and altered gene expression profiles. Journal of Cellular and Molecular Medicine, 14 (6b). pp. 1668.

McKelvey-Martin, Valerie J and McKenna, Declan (2009) Chapter 6. Development and Applications of the Comet-FISH Assay for the Study of DNA Damage and Repair. In: Comet Assay in Toxicology. Royal Society of Chemistry,, pp. 129-150. ISBN 978-0-85404-199-2

McKenna, Declan, McKeown, Stephanie and McKelvey-Martin, Valerie J (2008) Potential use of the comet assay in the clinical management of cancer. Mutagenesis, 23 (3). pp. 183-190.

Khan, Munir, McKenna, Declan, McKelvey-Martin, Valerie J, Kuiper, Jan Herman and Richardson, James B (2007) How does chromium and cobalt cause genetic damage?. Mutagenesis, 22 (6). pp. e1-e1.

McKenna, Declan (2007) Overview: Nutritional and cancer-related applications using comet assay. Mutagenesis, 22 (6). pp. e3-e3.

Rajab, Nor F, McKenna, Declan, Diamond, Jim, Williamson, Kate, Hamilton, Peter W and McKelvey-Martin, VJ (2006) Prediction of radiosensitivity in human bladder cell lines using nuclear chromatin phenotype.. Cytometry. Part A : the journal of the International Society for Analytical Cytology, 69 (10). pp. 1077-85.

Orr, Jenny, McKenna, Declan, McKelvey-Martin, Valerie J and Hamilton, PW (2005) HISTONE DEACETYLASE INHIBITION INDUCES ALTERED GENE EXPRESSION PROFILES IN PROSTATE CANCER. Cellular Oncology, 27. pp. 139.

Rajab, Nor F, McKenna, Declan, Diamond, Jim, Williamson, Kate, Hamilton, Peter W and McKelvey-Martin, Valerie J (2005) PREDICTION OF RADIOSENSITIVITY INHUMAN BLADDER CELL-LINES USINGNUCLEAR CHROMATIN PHENOTYPE. Cellular Oncology, 27. pp. 151.

Heavey, Patricia M, McKenna, Declan J and Rowland, Ian R (2004) Colorectal cancer and the relationship between genes and the environment.. Nutrition and cancer, 48 (2). pp. 124-41.

McKenna, Declan J, Rajab, Nor F, McKeown, Stephanie, McKerr, George and McKelvey-Martin, Valerie (2003) Use of the comet-FISH assay to demonstrate repair of the TP53 gene region in two human bladder carcinoma cell lines.. Radiation research, 159 (1). pp. 49-56.

McKenna, Declan J, Gallus, Massimo, McKeown, Stephanie, Downes, Stephen and McKelvey-Martin, Valerie (2003) Modification of the alkaline Comet assay to allow simultaneous evaluation of mitomycin C-induced DNA cross-link damage and repair of specific DNA sequences in RT4 cells.. DNA repair, 2 (8). pp. 879-90.

McKenna, Declan J (2001) Expression of the 67kDa Laminin Receptor (67LR) during Retinal Development: Correlations with Angiogenesis. Experimental Eye Research, 73 (1). pp. 81.

McKenna, Declan J, Nelson, J and Stitt, Alan (2001) Advanced glycation alters expression of the 67kDa laminin receptor in retinal microvascular endothelial cells. Life Sciences, 68 (24). pp. 2695.

Donaldson, E A, McKenna, Declan, McMullen, C B, Scott, W N, Stitt, A W and Nelson, J (2000) The expression of membrane-associated 67-kDa laminin receptor (67LR) is modulated in vitro by cell-contact inhibition.. Molecular cell biology research communications : MCBRC, 3 (1). pp. 53-9.

Mackay, Karen, McKenna, Declan and McKelvey-Martin, Valerie J (2000) Evaluation of mitomycin-C induced DNA damage and repair in RT4 bladder cancer cells using the alkaline comet assay.. Mutagenesis, 15. pp. 446.

Stitt, A W, McKenna, Declan, Simpson, D A, Gardiner, T A, Harriott, P, Archer, D B and Nelson, J (1998) The 67-kd laminin receptor is preferentially expressed by proliferating retinal vessels in a murine model of ischemic retinopathy.. The American journal of pathology, 152 (5). pp. 1359-65.

This list was generated on Wed May 25 08:09:03 2016 BST.