School of Biomedical Sciences

Skip Navigation |

  1. Background
  2. Contact
  3. Publications

McKillop, Aine Professor

Professor of Biomedical Sciences

Academic and Professional Qualifications
- 2005: FIBMS, Fellow of the Institute of Biomedical Science
- 2005: Registered Practitioner, The Higher Education Academy
- 2003-2004: Postgraduate Certificate in Higher Education and Teaching, University of Ulster
- 1996: PhD Clinical Medicine, Queen’s University of Belfast
- 1993: MSc Biomedical Sciences with Distinction, University of Ulster
- 1992: BSc (Hons) Biochemistry, Liverpool John Moores University

Career History
- 2002 - present: Lecturer in Clinical and Endocrine Biochemistry, University of Ulster
- 1998 - 2002: Research Fellow, University of Ulster
- 1996 - 1998: Research Fellow, Queen’s University of Belfast

Teaching & Learning Activities

Subject Areas: Clinical Biochemistry, Nutritional Biochemistry, Immunology and Pathology

Brief profile

- BSc Hons and PhD from Queen’s University, Belfast and MSc from the University of Ulster. Postdoctoral Research Fellow at Queen’s University, Belfast (1996-98) and the University of Ulster at Coleraine (1998-02) before taking up current appointment as Lecturer in Clinical Biochemistry at the University of Ulster in 2002. Patent holder and over 40 peer-reviewed publications and presentations at national and international conferences. Research interests and publications

- clinical biochemistry and diabetes proteomics
- cellular glucose handling and metabolism
- pancreatic beta-cell peptides and proteins
- mechanisms of insulin resistance and diabetes pathogenesis
- glycation of insulin and other key regulatory proteins
- structural and functional characterization of novel biomolecules
- insulin receptor dysfunction and novel treatments for diabetes.

Teaching interests
- Clinical and Nutritional Biochemistry and Pathology. Academic Coordinator for Teaching and Learning in the School of Biomedical Sciences.

McKillop, Aine Professor

space

Professor Aine McKillop
Professor of Biomedical Sciences
Biomedical Sciences Research Institute

space

Room Y131
School of Biomedical Sciences
University of Ulster
Coleraine campus
Cromore Road
Coleraine
Co. Londonderry
BT52 1SA

phone: +44 28 70123066
Email: am.mckillop@ulster.ac.uk

McKillop, Aine Professor - Publications

Number of items: 55.

Moran, BM, Abdel-Wahab, Yasser, Flatt, Peter and Mckillop, Aine (2014) Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreatic β-cells.. Diabetes Obesity and Metabolism, 16 (11). pp. 1128-1139.

Mckillop, Aine, Ng, MT, Abdel-Wahab, Yasser and Flatt, Peter (2014) Evidence for inhibitory autocrine effects of proinsulin C-peptide on pancreatic β-cell function and insulin secretion.. Diabetes Obesity and Metabolsim, 16 (10). pp. 937-946.

Moran, BM, Abdel-Wahab, Yasser, Flatt, Peter and Mckillop, Aine (2014) Activation of GPR119 by fatty acid agonists augments insulin release from clonal β-cells and isolated pancreatic islets and improves glucose tolerance in mice. Biological Chemistry, 395 (4). pp. 453-464.

Mckillop, Aine, Moran, BM, Abdel-Wahab, Yasser and Flatt, Peter (2013) Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice.. British Journal of Pharmacology, 170 (5). pp. 978-990.

Mckillop, Aine and Flatt, Peter (2011) Emerging Applications of Metabolomic and Genomic Profiling in Diabetic Clinical Medicine. DIABETES CARE, 34 (12). pp. 2624-2630.

Mckillop, Aine, Ng, MT, Flatt, Peter and Abdel-Wahab, Yasser (2011) Autocrine inhibitory effects of proinsulin C-peptide and insulin on insulin secretion and pancreatic beta cell function . Diabetologia, 54. pp. S258.

Taylor, Ashley, Irwin, Nigel, McKillop, Aine, Patterson, Steven, Flatt, Peter and Gault, Victor (2010) Evaluation of the degradation and metabolic effects of the gut peptide xenin on insulin secretion, glycaemic control and satiety. JOURNAL OF ENDOCRINOLOGY, 207 (1). pp. 87-93.

McKillop, Aine, Ng, MT, Flatt, Peter and Abdel-Wahab, Yasser (2010) Involvement of proinsulin C-peptide in the regulation of pancreatic beta cell function and glucose homeostasis. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 43.

Taylor, Ashley, Irwin, Nigel, McKillop, Aine, Flatt, Peter and Gault, Victor (2010) Xenin: An anorectic peptide involved in insulin secretion and glucose homeostasis. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 41.

Mckillop, Aine, Ng, MT, Flatt, Peter and Abdel-Wahab, Yasser (2010) Regulatory role for proinsulin C-peptide in pancreatic beta cell function and glucose homeostasis. . Irish Journal of Medical Science, 179. pp. 83.

Mckillop, Aine, Ng, MT, Flatt, Peter and Abdel-Wahab, Yasser (2009) Evidence for inhibitory autocrine effects of proinsulin C-peptide on pancreatic beta cell function and insulin secretion . DIABETOLOGIA , 52. pp. S167-S167.

McKillop, Aine, Duffy, NA, Lindsay, JR, Green, BD, Patterson, Steven, O'Harte, Finbarr, Bell, PM and Flatt, Peter (2009) Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation.. European Journal of Endocrinology, 16 (6). pp. 877-885.

Mckillop, Aine, Ng, MT, Flatt, Peter and Abdel-Wahab, Yasser (2009) Evidence for inhibitory autocrine effects of proinsulin C-peptide on pancreatic beta cell function and insulin secretion. DIABETOLOGIA, 52 (Suppl. 1). pp. 406.

Taylor, AI, Frizzell, N, McKillop, Aine, Flatt, Peter and Gault, Victor (2009) Effect of RU486 on hepatic and adipocyte gene expression improves diabetes control in obesity-type 2 diabetes.. Hormone Metabolic Research , 41 (12). pp. 899-904.

Ng, MT, Abdel-Wahab, Yasser, Flatt, Peter and Mckillop, Aine (2009) Autocrine effects of C-peptide on pancreatic beta cell function and insulin secretion in BRIN-BD11 cells and isolated islets . Irish Journal of Medical Science, 178. pp. S391.

Taylor, Ashley, Irwin, Nigel, McKillop, Aine, Flatt, Peter and Gault, Victor (2008) Sub-chronic administration of the 11 beta-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity. BIOLOGICAL CHEMISTRY, 389 (4). pp. 441-445.

McKillop, Aine, Duffy, Nicola A, Lindsay, John R, O'Harte, Finbarr, Bell, Patrick M and Flatt, Peter (2008) Decreased dipeptidyl peptidase-IV activity and glucagon-like peptide-1(7-36)amide degradation in type 2 diabetic subjects. DIABETES RESEARCH AND CLINICAL PRACTICE, 79 (1). pp. 79-85.

McKillop, Aine and Flatt, Peter (2008) Recent developments in the search for biomarkers for the diagnosis and monitoring of diabetes. Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, 2 (3). pp. 172-177.

McKillop, Aine, Duffy, NA, Green, BD, Irwin, Nigel, Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2007) Antidiabetic action of nateglinide includes augmentation of glucagon-like peptide-1 activity mediated partly through inhibition of DPP IV mediated degradation. DIABETOLOGIA, 50 (Suppl. 1). pp. 0882.

Gault, Victor, Taylor, AI, Irwin, Nigel, McKillop, Aine and Flatt, Peter (2007) Effects of 11 beta-hydroxysteroid dehydrogenase inhibition on body weight and glucose homeostasis in mice with diet-induced obesity. DIABETOLOGIA, 50 (Suppl. 1). pp. 0659.

Duffy, Nicola A, Green, Brian D, Irwin, Nigel, Gault, Victor, McKillop, Aine, O'Harte, Finbarr and Flatt, Peter (2007) Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: Nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1. EUROPEAN JOURNAL OF PHARMACOLOGY, 568 (1-3). pp. 278-286.

Gault, Victor, Taylor, AI, Irwin, Nigel, McKillop, Aine and Flatt, Peter (2007) Metabolic effects of 11beta-hydroxysteroid dehydrogenase inhibition in an animal model of diet-induced obesity. Irish Journal of Medical Science , 176 (S9). pp. 382-382.

Mckillop, Aine, Duffy, Nicola, Lindsay, John, Green, Brian, O'Harte, Finbarr, Bell, Patrick and Flatt, Peter (2007) Effects of nateglinide on DPP-IV activity and incretin hormone degradation in type 2 diabetic patients. Irish Journal of Medical Science, 176. pp. S367.

Doherty, Margaret, Patterson, Steven, Abdel-Wahab, Yasser and Mckillop, Aine (2007) Characterisation and detection of the insulinotropic hormones, GIP and GLP-1 in type 2 diabetes.. Irish Journal of Medical Science, 171. pp. 37.

McKillop, Aine, Duffy, NA, Lindsay, JR, Green, BD, O'Harte, Finbarr, Bell, PM and Flatt, Peter (2006) Insulinotropic actions of nateglinide are accompanied by inhibition of dipeptidyl peptidase-IV activity. DIABETOLOGIA, 49 (Suppl. 1). pp. 0796.

McKillop, Aine, Lindsay, JR, Au, S, Mahood, KI, O'Harte, Finbarr, Flatt, Peter and Bell, PM (2006) Meal-dependent regulation of circulating glycated insulin in type 2 diabetic subjects. HORMONE AND METABOLIC RESEARCH, 38 (2). pp. 94-97.

Lindsay, JR, Duffy, NA, McKillop, Aine, Ardill, J, O'Harte, Finbarr, Flatt, Peter and Bell, PM (2005) Inhibition of dipeptidyl peptidase IV activity by oral metformin in Type 2 diabetes. DIABETIC MEDICINE, 22 (5). pp. 654-657.

McKillop, Aine, Duffy, N, Lindsay, JR, Flatt, Peter, Bell, PM and O'Harte, Finbarr (2004) Decreased dipeptidyl peptidase-IV activity and degradation of glucagon-like peptide-1(7-36)amide in Type 2 diabetes. DIABETOLOGIA, 47 (Suppl. 1). pp. 792.

Mckillop, Aine, Lindsay, John, O'Harte, Finbarr, Bell, Patrick and Flatt, Peter (2004) Meal and glucose-dependent insulinotropic polypeptide regulation of circulating glycated insulin in type 2 diabetic subjects. . Diabetic Medicine, 21. pp. 6-7.

Lindsay, JR, McKillop, Aine, Mooney, MH, O'Harte, Finbarr, Flatt, Peter and Bell, PM (2003) Effects of nateglinide on the secretion of glycated insulin and glucose tolerance in type 2 diabetes. DIABETES RESEARCH AND CLINICAL PRACTICE, 61 (3). pp. 167-173.

Lindsay, JR, McKillop, Aine, Mooney, MH, Flatt, Peter, Bell, PM and O'Harte, Finbarr (2003) Meal-induced 24-hour profile of circulating glycated insulin in type 2 diabetic subjects measured by a novel radioimmunoassay. METABOLISM-CLINICAL AND EXPERIMENTAL, 52 (5). pp. 631-635.

McKillop, Aine, Meade, A, Flatt, Peter and O'Harte, Finbarr (2003) Evaluation of the site(s) of glycation in human proinsulin by ion-trap LCQ electrospray ionization mass spectrometry. REGULATORY PEPTIDES, 113 (1-3). pp. 1-8.

Lindsay, JR, McKillop, Aine, Mooney, MH, O'Harte, Finbarr, Bell, PM and Flatt, Peter (2003) Demonstration of increased concentrations of circulating glycated insulin in human Type 2 diabetes using a novel and specific radioimmunoassay. DIABETOLOGIA, 46 (4). pp. 475-478.

Hunter, SJ, Boyd, AC, O'Harte, Finbarr, McKillop, Aine, Wiggam, MI, Mooney, MH, McCluskey, Janie, Lindsay, JR, Ennis, CN, Gamble, R, Sheridan, B, Barnett, CR, McNulty, Helene, Bell, PM and Flatt, Peter (2003) Demonstration of glycated insulin in human diabetic plasma and decreased biological activity assessed by euglycemic-hyperinsulinemic clamp technique in humans. DIABETES, 52 (2). pp. 492-498.

Mckillop, Aine, O'Hare, Mairead, Craig, John and Halliday , Henry (2003) Analysis of the C-terminal region of the molecular forms of human milk bile salt stimulated lipase. Acta Paediatr, 92. pp. 1-7.

Lindsay, John, Duffy, Nicola, Mckillop, Aine, Ardill, Joy, O'Harte, Finbarr, Flatt, Peter and Bell, Patrick (2003) Inhibition of dipeptidyl peptidase IV (DPP-IV) activity by oral metformin in type 2 diabetes. Diabetic Medicine, 20. pp. 4-5.

Mckillop, Aine, Duffy, Nicola, Lindsay, John, O'Harte, Finbarr and Flatt, Peter (2003) Decreased activity of dipeptidyl peptidase-IV potentially enhances glucagon-like peptide-1(7-36)amide and gastric inhibitory polypeptide. . Diabetic Medicine, 20. pp. 37.

McKillop, Aine, Abdel-Wahab, Yasser, Mooney, MH, O'Harte, Finbarr and Flatt, Peter (2002) Secretion of glycated insulin from pancreatic beta-cells in diabetes represents a novel aspect of beta-cell dysfunction and glucose toxicity. DIABETES AND METABOLISM, 28 (6, Part 2). pp. S61-S69.

McKillop, Aine, Lindsay, JR, Mooney, MH, O'Harte, Finbarr, Bell, PM and Flatt, Peter (2002) Electrospray ionization mass spectrometry characterisation and measurement of circulating glycated insulin and responses to fasting and feeding in Type 2 diabetic subjects. DIABETOLOGIA, 45 (Suppl. 2). pp. 1221.

Mooney, MH, Abdel-Wahab, Yasser, McKillop, Aine, O'Harte, Finbarr and Flatt, Peter (2002) Evaluation of glycated glucagon-like peptide-1(7-36)amide in intestinal tissue of normal and diabetic animal models. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1569 (1-3). pp. 75-80.

Lindsay, John, Duffy, Nicola, Mckillop, Aine, Ardill, Joy, O'Harte, Finbarr, Flatt, Peter and Bell, Patrick (2002) Metformin inhibits dipeptidyl peptidase IV activity in type 2 diabetes. Irish Journal of Medical Science, 171. pp. 29.

Mckillop, Aine, Lindsay, John, Mooney, Mark, Flatt, Peter, Bell, John and O'Harte, Finbarr (2002) Detection, isolation and fluctuation of glycated insulin in type 2 diabetic subjects. Irish Journal of Medical Science, 171. pp. 31.

Lindsay, John, Mckillop, Aine, Mooney, Mark, O'Harte, Finbarr, Flatt, Peter and Bell, Patrick (2002) Demonstration of diurnal variation of plasma glycated insulin in type 2 diabetes.. Endocrine Abstracts, 3. pp. 85.

Lindsay, John, Mckillop, Aine, Mooney, Mark, O'Harte, Finbarr, Bell, Patrick and Flatt, Peter (2002) Elevated plasma glycated insulin in type 2 diabetes, detected using a novel radioimmunoassay.. Diabetic Medicine, 19. pp. 182.

McKillop, Aine, Mooney, MH, O'Harte, Finbarr and Flatt, Peter (2001) Evaluation of glycated insulin in plasma and biological tissues of diabetic animal models. DIABETOLOGIA, 44 (Suppl. 1). pp. 1222.

McKillop, Aine, Mooney, MH, Harriott, P, Flatt, Peter and O'Harte, Finbarr (2001) Evaluation of glycated insulin in diabetic animals using immunocytochemistry and radioimmunoassay. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 286 (3). pp. 524-528.

O'Harte, Finbarr, Mooney, MH, Kelly, CMN, McKillop, Aine and Flatt, Peter (2001) Degradation and glycemic effects of His(7)-glucitol glucagon-like peptide-1(7-36)amide in obese diabetic ob/ob mice. REGULATORY PEPTIDES, 96 (3). pp. 95-104.

Mckillop, Aine, Meade, Angela, Flatt, Peter and O'Harte, Finbarr (2001) Structural characterisation of glycated proinsulin. Irish Journal of Medical Science . Irish Journal of Medical Science, 170. pp. 11.

Lindsay, John, Mckillop, Aine, Mooney, Mark, O'Harte, Finbarr, Flatt, Peter and Bell, Patrick (2001) Detection of glycated insulin in plasma of type 2 diabetic subjects using a novel radioimmunoassay.. Irish Journal of Medical Science, 170. pp. 10.

McKillop, Aine, McCluskey, Janie, Boyd, AC, Mooney, MH, Flatt, Peter and O'Harte, Finbarr (2000) Production and characterization of specific antibodies for evaluation of glycated insulin in plasma and biological tissues. JOURNAL OF ENDOCRINOLOGY, 167 (1). pp. 153-163.

O'Harte, Finbarr, Boyd, AC, McKillop, Aine, Abdel-Wahab, Yasser, McNulty, Helene, Barnett, CR, Conlon, JM, Hojrup, P and Flatt, Peter (2000) Structure, antihyperglycemic activity and cellular actions of a novel diglycated human insulin. PEPTIDES, 21 (10). pp. 1519-1526.

Boyd, AC, Abdel-Wahab, Yasser, McKillop, Aine, McNulty, Helene, Barnett, CR, O'Harte, Finbarr and Flatt, Peter (2000) Impaired ability of glycated insulin to regulate plasma glucose and stimulate glucose transport and metabolism in mouse abdominal muscle. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1523 (1). pp. 128-134.

O'Harte, Finbarr, McKillop, Aine, Mooney, MH and Flatt, Peter (2000) Development and use of a specific radioimmunoassay for detection of glycated insulin in diabetes. DIABETOLOGIA, 43 (Suppl. 1). pp. 208.

McKillop, Aine, Abdel-Wahab, Yasser and Flatt, Peter (2000) The traditional plant treatment, Sambucus nigra (elder), exhibits insulin-like and insulin-releasing actions in vitro. JOURNAL OF NUTRITION, 130 (1). pp. 15-20.

Mckillop, Aine, O'Hare, Mairead, Craig, John and Halliday , Henry (1998) Incidence of molecular forms of human milk bile salt stimulated lipase. Pediatric Research , 43. pp. 101-104.

This list was generated on Thu Oct 23 01:38:38 2014 BST.