Mitchell, Christopher Dr
Senior Lecturer in DNA Metabolism
Academic and Professional Qualifications
2003: PGC Academic Practice, University of Nottingham
1993: PhD Philosophy (Anatomy and Human Biology/ Pathology) University of Western Austrailia
1987: BSc Anatomy and Human Biology, University of Western Australia, Perth
Career History
2004 - present: Lecturer in DNA Metabolism, University of Ulster
2000-2004: Lecturer (non-clinical), University of Nottingham
1998 - 2000: Cancer Research Campaign Research Associate, University of Nottingham
1995 - 1998: Max-Planck Fellow, Max-Planck Institut fur Physiol. Klin. Forsch. Parkstr. 1, Germany
1994-1995: Research Fellow, University of Western Australia.
1989-1989: Research Assistant, Dept. of Pathology, University of Western Australia
1988-1989: Technician, Dept of Clinical Biochemistry, Perth, Western Australia
1987-1987: Demonstrator in gross anatomy and histology, University of Western Australia
Teaching & Learning Activities
Module coordinator - DNA Technology and Oncology; Course Director - Molecular Biosciences
Mitchell, Christopher Dr
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Dr Christopher Mitchell |
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Room W1084 |
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Email: ca.mitchell@ulster.ac.uk
Mitchell, Christopher Dr - Publications
Ming, L, Byrne, N, Camac, SN, Ward, C, Mitchell, Christopher, Waugh, D, McKeown, Stephanie and Worthington, Jenny (2013) Androgen deprivation results in time-dependent hypoxia in LNCaP prostate tumours; informed scheduling of the bioreductive drug AQ4N improves treatment response.. International Journal of Cancer, 132. pp. 1323-1332.
Midha, Swati, van den Bergh, Wouter, Kim, Taek B., Lee, Peter D., Jones, Julian R. and Mitchell, Christopher A. (2012) Bioactive Glass Foam Scaffolds are Remodelled by Osteoclasts and Support the Formation of Mineralized Matrix and Vascular Networks In Vitro. Advanced Healthcare Materials, 2 (3). pp. 490.
McDougall, S. R., Watson, M. G., Devlin, A. H., Mitchell, C. A. and Chaplain, M. A. J. (2012) A Hybrid Discrete-Continuum Mathematical Model of Pattern Prediction in the Developing Retinal Vasculature. Bulletin of Mathematical Biology, 74 (10). pp. 2272.
Watson, M. G., McDougall, S. R., Chaplain, M. A. J., Devlin, A. H. and Mitchell, Christopher (2012) Dynamics of angiogenesis during murine retinal development: a coupled in vivo and in silico study. Journal of The Royal Society Interface, 9 (74). pp. 2351.
Aubert, M., Chaplain, M. A. J., McDougall, S. R., Devlin, A. and Mitchell, Christopher (2011) A Continuum Mathematical Model of the Developing Murine Retinal Vasculature. Bulletin of Mathematical Biology, ?.
Machado, Maria J.C., Watson, Michael G., Devlin, Andrea, Chaplain, Mark A.J., McDougall, Steven R. and Mitchell, Christopher (2011) Dynamics of Angiogenesis During Wound Healing: A Coupled In Vivo and In Silico Study. Microcirculation, 18 (3). pp. 183.
Machado, M. J. C. and Mitchell, Christopher (2011) Temporal changes in microvessel leakiness during wound healing discriminated by in vivo fluorescence recovery after photobleaching. The Journal of Physiology, 589 (19). pp. 4681.
ATWOOD, ROBERT C., LEE, PETER D., KONERDING, MORITZ A., ROCKETT, PETER and Mitchell, Christopher (2010) Quantitation of Microcomputed Tomography-Imaged Ocular Microvasculature. Microcirculation, 17 (1). pp. 59-68.
Yue, Sheng, Lee, Peter D., Poologasundarampillai, Gowsihan, Yao, Zhengzhong, Rockett, Peter, Devlin, Andrea, Mitchell, Christopher, Konerding, Moritz A. and Jones, Julian R. (2010) Synchrotron X-ray microtomography for assessment of bone tissue scaffolds. Journal of Materials Science: Materials in Medicine, 21 (3). pp. 847-853.
Mitchell, Christopher, Rutland, CS, Jiang, K and Soff, G (2009) Maternal administration of anti-angiogenic agents, TNP-470 and Angiostatin4.5, induces fetal microphthalmia. Molecular Vision, 15. pp. 1260-1269.
Guerreiro-Lucas, Luciano A, Pop, S. Rares, Ma, Maria J C Machado and Ying Liang, Waters, Sarah L, Richardson, Giles, Saetzler, Kurt, Jensen, Oliver E and Mitchell, Christopher (2008) Experimental and theoretical modelling of blind-ended vessels within a developing angiogenic plexus.. Microvasc Res, 76. pp. 161-168.
Mitchell, Christopher, Lee, PD, Atwood, RC, Rockett, P, Konerding, MA and Jones, JR (2008) A comparison of three diferent micro-tomography systems for accurate determination of microvascular parameters. Proceedings of SPIE, the International Society for Optical Engineering, 7078. pp. 780-780.
Lee, P. D., Atwood, R. C., Rockett, P., Konerding, M. A., Jones, J. R. and Mitchell, Christopher (2008) A comparison of three different micro-tomography systems for accurate determination of microvascular parameters - art. no. 70780E. In: DEVELOPMENTS IN X-RAY TOMOGRAPHY VI. SPIE digital library. Vol 7078 E780
Rutland, Catrin S., Mitchell, Christopher, Nasir, Muneeb, Konerding, Moritz A. and Drexler, Hannes C. A. (2007) Microphthalmia, persistent hyperplastic hyaloid vasculature and lens anomalies following overexpression of VEGF-A(188) from the alpha A-crystallin promoter. MOLECULAR VISION, 13 (6). pp. 47-56.
Bigot, S., Lucas, L., Morrow, PJ, Mitchell, Christopher and Saetzler, Kurt (2007) Estimating leukocyte velocities from high-speed 1D line scans oriented orthogonal to blood flow. In: Biomedical Imaging: Macro to Nano, 2007. 4rd IEEE International Symposium on, Washington. . 376-379
Bigot, Stephane, Lucas, Luciano, Morrow, Philip, Mitchell, Christopher and Saetzler, Kurt (2007) Estimating leukocyte velocities from high-speed 1D line scans oriented orthogonal to blood flow. In: 2007 4TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING : MACRO TO NANO, VOLS 1-3. ISBI. 376-379
McEnery, O., Lucas, L., Ma, YingLiang, Morrow, PJ, Mitchell, Christopher and Saetzler, Kurt (2006) A fast, robust and scale-independent approach to estimate vessel diameters in intravital fluorescence microscopy images. In: Biomedical Imaging: Macro to Nano, 2006. 3rd IEEE International Symposium on. . 101-104
Mitchell, Christopher, Rutland, Catrin S., Walker, Michael, Nasir, Muneeb, Foss, Alexander J. E., Stewart, Christine, Gerhardt, Holger, Konerding, Moritz A., Risau, Werner and Drexler, Hannes C. A. (2006) Unique vascular phenotypes following over-expression of individual VEGFA isoforms from the developing lens. Angiogenesis, 9 (4). pp. 209.
Rutland, CS, Mukhopadhyay, M, Underwood, S, Clyde, N, Mayhew, TM and Mitchell, Christopher (2005) Induction of intrauterine growth restriction by reducing placental vascular growth with the angioinhibin TNP-470. BIOLOGY OF REPRODUCTION, 73 (6). pp. 1164-1173.
Hanford, HA, Wong, CA, Kassan, H, Cundiff, DL, Chandel, N, Underwood, S, Mitchell, Christopher and Soff, GA (2003) Angiostatin(4.5)-mediated apoptosis of vascular endothelial cells. CANCER RESEARCH, 63 (14). pp. 4275-4280.
Gerhardt, H, Golding, M, Fruttiger, M, Ruhrberg, C, Lundkvist, A, Abramsson, A, Jeltsch, M, Mitchell, Christopher, Alitalo, K, Shima, D and Betsholtz, C (2003) VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. JOURNAL OF CELL BIOLOGY, 161 (6). pp. 1163-1177.
Mayhew, T, Mitchell, Christopher, Ohadikea, C, Bakerb, PN, Crockerb, IP and Ongc, SS (2003) Stereological Investigation of Placental Morphology in Pregnancies Complicated by Pre-eclampsia with and without Intrauterine Growth Restriction. Placenta, 24 (2-3). pp. 219.
Edel, M, Robbins, P, D'Antuono, M, Harvey, J, Papadimitriou, J, Mitchell, Christopher and Dawkins, H (2000) Assessment of endothelial cell proliferation in primary breast carcinoma and its association with axillary lymph node status. BREAST, 9 (1). pp. 28-34.
Mitchell, Christopher, Risau, W and Drexler, HCA (1998) Regression of vessels in the tunica vasculosa lentis is initiated by coordinated endothelial apoptosis: A role for vascular endothelial growth factor as a survival factor for endothelium. DEVELOPMENTAL DYNAMICS, 213 (3). pp. 322-333.
Knies, UE, Behrensdorf, HA, Mitchell, Christopher, Deutsch, U, Risau, W, Drexler, HCA and Clauss, M (1998) Regulation of endothelial monocyte-activating polypeptide II release by apoptosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 95 (21). pp. 12322-12327.
Mitchell, Christopher, Edel, M, Robbins, P, Papadimitriou, JM, D'antuono, M, Harvey, J and Dawkins, HJS (1998) Assessment of vascularity in breast carcinoma by computer-assisted video analysis (CAVA) and its association with axillary lymph node status. Breast Cancer Research Treatment, 47 (1). pp. 17-27.
Davies, MJ, Mitchell, Christopher, Maley, MAL, Grounds, MD, Harvey, AR, Plant, GW, Wood, DJ, Hong, Y and Chirila, TV (1997) In vitro assessment of the biological activity of basic fibroblast growth factor released from various polymers and biomatrices. JOURNAL OF BIOMATERIALS APPLICATIONS, 12 (1). pp. 31-56.
Mitchell, Christopher, Davies, MJ, Grounds, MD, McGeachie, JK, Crawford, GJ, Hong, Y and Chirila, TV (1996) Enhancement of neovascularization in regenerating skeletal muscle by the sustained release of erucamide from a polymer matrix. JOURNAL OF BIOMATERIALS APPLICATIONS, 10 (3). pp. 230-249.
Mitchell, Christopher, Davies, MJ, Grounds, MD, McGeachie, JK, Crawford, GJ, Hong, Y and Chirila, TV (1996) Enhancement of neovascularization in regenerating skeletal muscle by the sustained release of erucamide from a polymer matrix. JOURNAL OF BIOMATERIALS APPLICATIONS, 10 (3). pp. 230-249.
Mitchell, Christopher, McGeachie, JK and Grounds, MD (1996) The exogenous administration of basic fibroblast growth factor to regenerating skeletal muscle in mice does not enhance the process of regeneration. GROWTH FACTORS, 13 (1-2). pp. 37-55.
KAY, PH, Mitchell, Christopher, AKKARI, A and PAPADIMITRIOU, JM (1995) ASSOCIATION OF AN UNUSUAL FORM OF A PAX7-LIKE GENE WITH INCREASED EFFICIENCY OF SKELETAL-MUSCLE REGENERATION. GENE, 163 (2). pp. 171-177.
Mitchell, Christopher, GROUNDS, MD and PAPADIMITRIOU, JM (1995) THE GENOTYPE OF BONE-MARROW-DERIVED INFLAMMATORY CELLS DOES NOT ACCOUNT FOR DIFFERENCES IN SKELETAL-MUSCLE REGENERATION BETWEEN SJL/J AND BALB/C MICE. CELL AND TISSUE RESEARCH, 280 (2). pp. 407-413.
ANDERSON, JE, Mitchell, Christopher, MCGEACHIE, JK and GROUNDS, MD (1995) THE TIME-COURSE OF BASIC FIBROBLAST GROWTH-FACTOR EXPRESSION IN CRUSH-INJURED SKELETAL-MUSCLES OF SJL/J AND BALB/C MICE. EXPERIMENTAL CELL RESEARCH, 216 (2). pp. 325-334.
KAY, PH, PEREIRA, E, MARLOW, SA, TURBETT, G, Mitchell, Christopher, JACOBSEN, PF, HOLLIDAY, R and PAPADIMITRIOU, JM (1994) EVIDENCE FOR ADENINE METHYLATION WITHIN THE MOUSE MYOGENIC GENE MYO-D1. GENE, 151 (1-2). pp. 89-95.
KAY, PH, MARLOW, SA, Mitchell, Christopher and PAPADIMITRIOU, JM (1993) STUDIES ON THE EVOLUTION AND FUNCTION OF DIFFERENT FORMS OF THE MOUSE MYOGENIC GENE MYO-D1 AND UPSTREAM FLANKING REGION. GENE, 124 (2). pp. 215-222.
Mitchell, Christopher, GROUNDS, MD and PAPADIMITRIOU, JM (1992) BONE-MARROW ISOGRAFTING BETWEEN SJL/J AND BALB/C MICE DOES NOT INFLUENCE THE STRAIN SPECIFIC DIFFERENCES IN THE REGENERATION OF SKELETAL-MUSCLE AFTER CRUSH INJURY. MOLECULAR BIOLOGY OF THE CELL, 3 (Suppl. S). pp. A253.
Mitchell, Christopher, MCGEACHIE, JK and GROUNDS, MD (1992) CELLULAR DIFFERENCES IN THE REGENERATION OF MURINE SKELETAL-MUSCLE - A QUANTITATIVE HISTOLOGICAL STUDY IN SJL/J AND BALB/C MICE. CELL AND TISSUE RESEARCH, 269 (1). pp. 159-166.
CHLEBOUN, JO, MARTINS, RN, Mitchell, Christopher and CHIRILA, TV (1992) BFGF ENHANCES THE DEVELOPMENT OF THE COLLATERAL CIRCULATION AFTER ACUTE ARTERIAL-OCCLUSION. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 185 (2). pp. 510-516.
GROUNDS, MD, ROBERTSON, TA, Mitchell, Christopher and PAPADIMITRIOU, JM (1992) NECROSIS AND REGENERATION IN DYSTROPHIC AND NORMAL SKELETAL-MUSCLE. In: DUCHENNE MUSCULAR DYSTROPHY - ANIMAL MODELS AND GENETIC MANIPULATION . Raven Press Ltd New York. 141-153
Mitchell, Christopher, Grounds, MD and McGeachie, JK (1992) The effect of low dose dexamethasone on skeletal muscle regeneration in vivo. Basic Applied Myology, 1. pp. 139-144.
GROUNDS, MD, ROBERTSON, TA, MITCHELL, CA and PAPADIMITRIOU, JM (1992) NECROSIS AND REGENERATION IN DYSTROPHIC AND NORMAL SKELETAL-MUSCLE. In: DUCHENNE MUSCULAR DYSTROPHY - ANIMAL MODELS AND GENETIC MANIPULATION . OXford University Press. 141-153
ROBERTSON, TA, GROUNDS, MD, Mitchell, Christopher and PAPADIMITRIOU, JM (1990) FUSION BETWEEN MYOGENIC CELLS INVIVO - AN ULTRASTRUCTURAL-STUDY IN REGENERATING MURINE SKELETAL-MUSCLE. JOURNAL OF STRUCTURAL BIOLOGY, 105 (1-3). pp. 170-182.
PAPADIMITRIOU, JM, ROBERTSON, TA, Mitchell, Christopher and GROUNDS, MD (1990) THE PROCESS OF NEW PLASMALEMMA FORMATION IN FOCALLY INJURED SKELETAL-MUSCLE FIBERS. JOURNAL OF STRUCTURAL BIOLOGY, 103 (2). pp. 124-134.
