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McKeown, Stephanie Professor

Professor of Cancer Biology

Academic and Professional Qualifications
- 2000: CBiol MIBiol, Institute of Biology
- 1989: Advanced Diploma in Further Education, (Part 1), University of Ulster
- 1977: PhD, Queen’s University Belfast
- 1977: MA (oxon)
- 1973: BA (2:1), Natural Sciences, Biochemistry, (Oxon)

Career History
- 1991 - Present: Lecturer / Senior Lecturer / Reader / Professor, School of Biomedical Sciences
- 1989 - 1991: Research Fellow, Queens University of Belfast
- 1988 - 1989: Lecturer in Biological Sciences, Belfast College of Technology
- 1981 - 1988: Career Break
- 1980 - 1981: Research Fellow, Queens University of Belfast
- 1974 - 1980: Biochemist/Senior Biochemist, Dept. of Neuropathology, RVH, Belfast
- 1973- 1974: Research Assistant, Dept. of Neuropathology, Queen’s University of Belfast

McKeown, Stephanie Professor


McKeown, Stephanie Professor - Publications

Number of items: 65.

Nesbitt, Heather, Byrne, Niall M., Williams, S. Nicole, Ming, Louise, Worthington, Jenny, Errington, Rachel J., Patterson, Laurence H., Smith, Paul J., McKeown, Stephanie and McKenna, Declan (2016) Targeting Hypoxic Prostate Tumors Using the Novel Hypoxia-Activated Prodrug OCT1002 Inhibits Expression of Genes Associated with Malignant Progression. Clinical Cancer Research, 2016.

Nesbitt, Heather, Byrne, Niall, Ming, Louise, Worthington, Jenny, Errington, Rachel, Patterson, Laurence, Smith, Paul, McKeown, Stephanie and McKenna, Declan (2016) Targeting hypoxic prostate tumours using the novel hypoxia-activated prodrug OCT1002 inhibits expression of genes associated with malignant expression. Ulster Medical Journal, 86 (1). pp. 11-11.

Byrne, NM, Nesbitt, Heather, Ming, L, McKeown, Stephanie, Worthington, Jenny and McKenna, Declan (2016) Androgen deprivation in LNCaP prostate tumour xenografts induces vascular changes and hypoxic stress, resulting in promotion of epithelial-to-mesenchymal transition. British Journal of Cancer, epub.

Nesbitt, Heather, byrne, niall, Worthington, Jenny, McKeown, Stephanie and McKenna, Declan (2015) Targeting hypoxia in prostate cancer cells to increase treatment efficacy. Ulster Medical Journal, 84 (3). pp. 209-210.

Smith, Paul, Wiltshire, Marie, Nesbitt, Heather, Byrne, Niall, Ming, Louise, McKenna, Declan, Worthington, Jenny, McKeown, Stephanie, Patterson, Laurence and Errington, Rachel (2015) Cytometry of Anticancer Prodrug OCT1002 Activation and Targeting Using In Vitro and In Vivo Models of Tumour Hypoxia. In: CYTO 2015, the 30th Congress of the International Society for Advancement of Cytometry, Glasgow,Scotland. International Society for Advancement of Cytometry. 128

O'Donovan, Katie, Nesbitt, Heather, McKeown, Stephanie, Camac, Nicole and McKenna, Declan (2015) Characterization of 22RV1-Luc xenograft response to androgen-deprivation therapy.. In: 2015 Keystone Symposia Conference E3: Hypoxia: From Basic Mechanisms to Therapeutics, Dublin, Ireland. Keystone Symposia.

cochrane, david, o'donovan, katie, Nesbitt, Heather, McKeown, Stephanie, Worthington, Jenny, o'rourke, martin, James, Iain and McKenna, Declan (2015) Characterisation of novel AKT inhibitor in treatment of androgen sensitive prostate cancer. In: Irish Association for Cancer Research 2015, Limerick. Irish Association for Cancer Research.

Nesbitt, Heather, Browne, Gillian, O'Donovan, Katie M., Byrne, Niall M., Worthington, Jenny, McKeown, Stephanie and McKenna, Declan J (2015) Nitric Oxide Up-Regulates RUNX2 in LNCaP Prostate Tumours: Implications for Tumour Growth In Vitro and In Vivo. Journal of Cellular Physiology, 231 (2). pp. 473-482.

Rashid, Shazia, Unyayar, Ali, Mazmanci, Mehmet Ali, McKeown, Stephanie R., Worthington, Jenny and Banat, Ibrahim (2014) Potential of a Funalia trogii laccase enzyme as an anticancer agent. Ann Microbiol (2015) 65:175183, 65. pp. 175-183.

Ming, L, Byrne, N, Camac, SN, Ward, C, Mitchell, Christopher, Waugh, D, McKeown, Stephanie and Worthington, Jenny (2013) Androgen deprivation results in time-dependent hypoxia in LNCaP prostate tumours; informed scheduling of the bioreductive drug AQ4N improves treatment response.. International Journal of Cancer, 132. pp. 1323-1332.

Bowman, Karen J, Al-Moneef, Manar M, Sherwood, Benedict T, Colquhoun, Alexandra J, Goddard, Jonathan C, Griffiths, T R Leyshon, Payne, David, Singh, Sadmeet, Butterworth, Paul C, Khan, Masood A, Summerton, Duncan J, Steward, William P, McKelvey-Martin, Valerie J, McKeown, Stephanie, Kockelbergh, Roger C, Mellon, J Kilian, Symonds, R Paul and Jones, George D D (2013) Comet assay measures of DNA damage are predictive of bladder cancer cell treatment sensitivityin vitroand outcomein vivo. International Journal of Cancer, TBC. pp. n/a.

McKenna, Declan J, Doherty, Bernadette, Downes, Stephen, McKeown, SR and McKelvey-Martin, Valerie J (2012) Use of the Comet-FISH Assay to Compare DNA Damage and Repair in p53 and hTERT Genes following Ionizing Radiation. PLoS ONE, 7 (11). pp. e49364.

Browne, G, Nesbitt, H, Ming, L, Stein, GS, Lian, JB, McKeown, SR and Worthington, Jenny (2012) Bicalutamide-induced hypoxia potentiates RUNX2-mediated Bcl-2 expression resulting in apoptosis resistance.. British Journal of Cancer, 107. pp. 1714-1721.

Worthington, Jenny, McKeown, Stephanie and Banat, Ibrahim (2011) A study of anti-cancer effects of Funalia trogii in vitro and in vivo. Food and Chemical Toxicology, 49 (7). pp. 1477-1483.

Devlin, Andrea, Thompson, Paul, Robson, Tracy and McKeown, SR (2010) Cytochrome P450 1B1 mRNA Untranslated Regions Interact to Inhibit Protein Translation. Molecular Carcinogenesis, 49 (2). pp. 190-199.

Devlin, Andrea, Mcllroy, Marie, McKeen, Hayley D., Bonde, Pramode, Menezes, A. A. Carlos, Swarbrick, Christine J., Robson, Tracy, Hirst, David G., Campbell, F. Charles, McGuigan, James A. and McKeown, Stephanie (2009) Cytochrome P450 1B1 Expression in Rat Esophageal Tumorigenesis Promoted by Gastric and Duodenal Reflux. MOLECULAR CARCINOGENESIS, 48 (2). pp. 110-117.

Wilson, C, Scullin, P, Worthington, Jenny, Seaton, A, Maxwell, P, O'Rourke, D, Johnston, PG, McKeown, Stephanie, Wilson, RH, O'Sullivan, JM and Waugh, DJJ (2008) Dexamethasone potentiates the antiangiogenic activity of docetaxel in castration-resistant prostate cancer. BRITISH JOURNAL OF CANCER, 99 (12). pp. 2054-2064.

Butterworth, Karl T, McCarthy, Helen O, Devlin, Andrea, Ming, Louise, Robson, Tracy, McKeown, Stephanie and Worthington, Jenny (2008) Hypoxia selects for androgen independent LNCaP cells with a more malignant geno- and phenotype. INTERNATIONAL JOURNAL OF CANCER, 123 (4). pp. 760-768.

O'Rourke, Martin, Ward, Claire, Worthington, Jenny, McKenna, Julie, Valentine, Andrea, Robson, Tracy, Hirst, David G and McKeown, Stephanie (2008) Evaluation of the antiangiogenic potential of AQ4N. CLINICAL CANCER RESEARCH, 14 (5). pp. 1502-1509.

McKenna, Declan, McKeown, Stephanie and McKelvey-Martin, Valerie J (2008) Potential use of the comet assay in the clinical management of cancer. Mutagenesis, 23 (3). pp. 183-190.

O'Keeffe, Martina B, Devlin, Andrea, Burns, Alan J, Gardiner, Tom A, Logan, Ian, Hirst, David G and McKeown, Stephanie (2008) Investigation of pericytes, hypoxia, and vascularity in bladder tumors: Association with clinical outcomes. ONCOLOGY RESEARCH, 17 (3). pp. 93-101.

McKeown, Stephanie, Cowen, RL and Williams, KJ (2007) Bioreductive drugs: from concept to clinic. CLINICAL ONCOLOGY, 19 (6). pp. 427-442.

McCarthy, HO, Worthington, Jenny, Barrett, E, Cosimo, E, Boyd, M, Mairs, RJ, Ward, C, McKeown, Stephanie, Hirst, DG and Robson, T (2007) p(21(WAF1))-mediated transcriptional targeting of inducible nitric oxide synthase gene therapy sensitizes tumours to fractionated radiotherapy. GENE THERAPY, 14 (3). pp. 246-255.

Doherty, Sharon C, McKeown, Stephanie R, Lopez, Jesus A, Walsh, Ian K and McKelvey-Martin, Valerie (2006) Gene expression in normal Urothelium depends on location within the bladder: A possible link to bladder carcinogenesis. EUROPEAN UROLOGY, 50 (2). pp. 290-301.

Doherty, Sharon C, McKeown, SR, Lopez, Jesus A, Walsh, Ian K and McKelvey-Martin, Valerie J (2006) Gene expression in normal Urothelium depends on location within the bladder: A possible link to bladder carcinogenesis. European Urology, 50 (2). pp. 290-301.

Yakkundi, A, McErlane, V, Murray, M, McCarthy, HO, Ward, C, Hughes, Ciara, Patterson, LH, Hirst, DG, McKeown, Stephanie and Robson, T (2006) Tumor-selective drug activation: a GDEPT approach utilizing cytochrome P450 1A1 and AQ4N. CANCER GENE THERAPY, 13 (6). pp. 598-605.

McKeown, SR and Jones, B (2006) DNA repair: therapeutic implications. The British Journal of Radiology, 79 (938). pp. 91-93.

McIlroy, M, O'Rourke, M, McKeown, Stephanie, Hirst, DG and Robson, T (2006) Pericytes influence endothelial cell growth characteristics: Role of plasminogen activator inhibitor type 1 (PAI-1). CARDIOVASCULAR RESEARCH, 69 (1). pp. 207-217.

Robson, T, Worthington, Jenny, McKeown, Stephanie and Hirst, DG (2005) Radiogenic therapy: Novel approaches for enhancing tumor radiosensitivity. TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 4 (4). pp. 343-361.

McErlane, V, Yakkundi, A, McCarthy, HO, Hughes, Ciara, Patterson, LH, Hirst, DG, Robson, T and McKeown, Stephanie (2005) A cytochrome P4502B6 meditated gene therapy strategy to enhance the effects of radiation or cyclophosphamide when combined with the bioreductive drug AQ4N. JOURNAL OF GENE MEDICINE, 7 (7). pp. 851-859.

McCarthy, HO, Worthington, Jenny, Ward, C, Barrett, E, Hirst, DG, McKeown, Stephanie and Robson, T (2004) Use of the p2l/WAF1 promoter for transcriptional targetting in cancer gene therapy. JOURNAL OF GENE MEDICINE, 6 (9). pp. 78.

McKeown, SR, Ward, C and Robson, T (2004) Gene-directed enzyme prodrug therapy: A current assessment. CURRENT OPINION IN MOLECULAR THERAPEUTICS, 6 (4). pp. 421-435.

Doherty, SC, McKeown, Stephanie, McKelvey-Martin, Valerie, Downes, Stephen, Atala, A, Yoo, JJ, Simpson, DA and Kaufmann, WK (2003) Cell cycle checkpoint function in bladder cancer. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 95 (24). pp. 1859-1868.

Dunne, AL, Price, ME, Mothersill, C, McKeown, Stephanie, Robson, T and Hirst, DG (2003) Relationship between clonogenic radiosensitivity, radiation-induced apoptosis and DNA damage/repair in human colon cancer cells. BRITISH JOURNAL OF CANCER, 89 (12). pp. 2277-2283.

McKeown, Stephanie, Robson, T, Price, ME, Ho, ETS, Hirst, DG and McKelvey-Martin, Valerie (2003) Potential use of the alkaline comet assay as a predictor of bladder tumour response to radiation. BRITISH JOURNAL OF CANCER, 89 (12). pp. 2264-2270.

McCarthy, Helen, Yakkundi, A, McErlane, V, Hughes, Ciara, Keilty, G, Murray, Margaret, Patterson, LH, Hirst, DG, McKeown, SR and Robson, T (2003) Bioreductive GDEPT using cytochrome P450 3A4 in combination with AQ4N. Cancer Gene Therapy, 10 (1). pp. 40-48.

McKenna, Declan J, Gallus, Massimo, McKeown, Stephanie, Downes, Stephen and McKelvey-Martin, Valerie (2003) Modification of the alkaline Comet assay to allow simultaneous evaluation of mitomycin C-induced DNA cross-link damage and repair of specific DNA sequences in RT4 cells.. DNA repair, 2 (8). pp. 879-90.

McKenna, Declan J, Rajab, Nor F, McKeown, Stephanie, McKerr, George and McKelvey-Martin, Valerie (2003) Use of the comet-FISH assay to demonstrate repair of the TP53 gene region in two human bladder carcinoma cell lines.. Radiation research, 159 (1). pp. 49-56.

McGreal, Stanley, Hughes, Ciara, Murray, Margaret, Friery, OP, Patterson, LH, Hirst, DG and McKeown, SR (2001) The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N. British Journal of Cancer, 85 (4). pp. 625-629.

McKeown, Stephanie, Hughes, Ciara, Keilty, Gillian, McCarthy, Helen, Murray, Margaret, Hirst, David and Robson, Tracy (2001) Manipulation of P450 gene expression in tumours; A novel approach for targeted activation of bioreductive prodrugs. In: Invited presentations on cancer. Nature Publishing Group. Vol 85 (Suppl.), 14-14

Patterson, LH and McKeown, Stephanie (2000) AQ4N: a new approach to hypoxia-activated cancer chemotherapy. BRITISH JOURNAL OF CANCER, 83 (12). pp. 1589-1593.

Al-Assar, O, Robson, T, McKeown, Stephanie, Gardin, I, Wilson, GD and Hirst, DG (2000) Regulation of FOS by different compartmental stresses induced by low levels of ionizing radiation. RADIATION RESEARCH, 154 (5). pp. 503-514.

Patterson, LH, McKeown, Stephanie, Ruparella, K, Double, JA, Bibby, MC, Cole, S and Stratford, IJ (2000) Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent. BRITISH JOURNAL OF CANCER, 82 (12). pp. 1984-1990.

Price, ME, McKelvey-Martin, Valerie, Robson, T, Hirst, DG and McKeown, Stephanie (2000) Induction and rejoining of DNA double-strand breaks in bladder tumor cells. RADIATION RESEARCH, 153 (6). pp. 788-794.

Robson, T, Price, ME, Moore, ML, Joiner, MC, McKelvey-Martin, Valerie, McKeown, Stephanie and Hirst, DG (2000) Increased repair and cell survival in cells treated with DIR1 antisense oligonucleotides: implications for induced radioresistance. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 76 (5). pp. 617-623.

Friery, OP, Gallagher, R, Murray, MM, Hughes, Ciara, Galligan, ES, McIntyre, Irene, Patterson, LH, Hirst, DG and McKeown, Stephanie (2000) Enhancement of the anti-tumour effect of cyclophosphamide by the bioreductive drugs AQ4N and tirapazamine. BRITISH JOURNAL OF CANCER, 82 (8). pp. 1469-1473.

Ruddock, MW, Burns, DM, McKeown, Stephanie, Murphy, L, WAlsh, IK, Keane, PF and Hirst, DG (2000) Contractile properties of human renal cell carcinoma recruited arteries and their response to nicotinamide. RADIOTHERAPY AND ONCOLOGY, 54 (2). pp. 179-184.

Martin, AR, Bailie, JR, Robson, T, McKeown, Stephanie, Al-Assar, O, McFarland, A and Hirst, DG (2000) Retinal pericytes control expression of nitric oxide synthase and endothelin-1 in microvascular endothelial cells. MICROVASCULAR RESEARCH, 59 (1). pp. 131-139.

Patterson, LH, McKeown, Stephanie, Robson, T, Gallagher, R, Raleigh, SM and Orr, S (1999) Antitumour prodrug development using cytochrome P450 (CYP) mediated activation. ANTI-CANCER DRUG DESIGN, 14 (6). pp. 473-486.

Robson, T, Joiner, MC, Wilson, GD, McCullough, William, Price, ME, Logan, Ian, Jones, H, McKeown, Stephanie and Hirst, DG (1999) A novel human stress response-related gene with a potential role in induced radioresistance. RADIATION RESEARCH, 152 (5). pp. 451-461.

Raleigh, SM, Wanogho, E, Burke, MD, McKeown, Stephanie and Patterson, LH (1998) Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 42 (4). pp. 763-767.

McKelvey-Martin, Valerie, Ho, ETS, McKeown, Stephanie, Johnston, SR, McCarthy, PJ, Rajab, NF and Downes, Stephen (1998) Emerging applications of the single cell gel electrophoresis (Comet) assay. I. Management of invasive transitional cell human bladder carcinoma. II. Fluorescent in situ hybridization Comets for the identification of damaged and repaired DNA sequences in individual cells. MUTAGENESIS, 13 (1). pp. 1-8.

Galligan, ES, Sweetman, SF, McKeown, SR and Strain, JJ (1996) An investigation of the radioprotective action of dietary antioxidants on P388 murine lymphoblastic cells. IRISH JOURNAL OF MEDICAL SCIENCE, 165 (4). pp. 304-305.

Hejmadi, MV, McKeown, SR, Friery, OP, McIntyre, Irene, Patterson, LH and Hirst, DG (1996) DNA damage following combination of radiation with the bioreductive drug AQ4N: Possible selective toxicity to oxic and hypoxic tumour cells. British Journal of Cancer, 73 (4). pp. 499-505.

McKeown, SR, HEJMADI, MV, MCINTYRE, IA, MCALEER, JJA and PATTERSON, LH (1995) Aq4n - an alkylaminoanthraquinone n-oxide showing bioreductive potential and positive interaction with radiation in-vivo. British Journal of Cancer, 72 (1). pp. 76-81.

JOINER, B, HIRST, VK, McKeown, SR, MCALEER, JJA and HIRST, DG (1993) The effect of recombinant-human-erythropoietin treatment on tumor radiosensitivity and cancer-associated anemia in the mouse. British Journal of Cancer, 68 (4). pp. 720-726.

MCALEER, JJA, McKeown, SR, MACMANUS, MP, LAPPIN, TRJ and BRIDGES, JM (1992) Hypobaric hypoxia - a method for testing bioreductive drugs invivo. International Journal of Radiation Oncology Biology Physics, 23 (3). pp. 551-555.

McKeown, SR and ALLEN, IV (1980) Brain temperature after death. Journal of Neuroscience Methods, 2 (1). pp. 103-105.

McKeown, SR (1979) Postmortem autolytic response in rat-brain lysosomes. Journal of Neurochemistry, 32 (2). pp. 391-396.

ALLEN, IV, GLOVER, G, McKeown, SR and MCCORMICK, D (1979) Cellular-origin of lysosomal enzymes in the plaque in multiple-sclerosis .2. Histochemical-study with combined demonstration of myelin and acid-phosphatase. Neuropathology and Applied Neurobiology, 5 (3). pp. 197-210.

McKeown, SR and ALLEN, IV (1979) Fragility of cerebral lysosomes in multiple-sclerosis. Neuropathology and Applied Neurobiology, 5 (5). pp. 405-415.

McKeown, SR (1978) Role of cerebral lysosomes in multiple-sclerosis. IRISH JOURNAL OF MEDICAL SCIENCE, 147 (3). pp. 119.

McKeown, SR and ALLEN, IV (1978) Cellular origin of lysosomal enzymes in the plaque in multiple-sclerosis - combined histological and biochemical study. Neuropathology and Applied Neurobiology, 4 (6). pp. 471-482.

McKeown, SR and ALLEN, IV (1977) Lysosomal involvement in pathogenesis of Multiple-Sclerosis. Biochemical Society Transactions, 5 (5). pp. 1416-1418.

Williamson, DH, McKeown, SR and Ilic, V (1975) Metabolic Interactions of Glucose, Acetoacetate and Insulin in Mammary- Glad Slices of Lactating Rats. Biochemical Journal, 150 (2). pp. 145-152.

This list was generated on Sat Jun 24 13:09:14 2017 BST.