University of Ulster

Jena, Sarita, Lee , Wai-Ping, Doherty, Declan and Thompson, Paul (2012) PIAS4 represses vitamin D receptor-mediated signaling and acts as an E3-SUMO ligase towards vitamin D receptor.. The Journal of Steroid Biochemistry and Molecular Biology, 132 (1-2). pp. 24-31.

Maguire, Orla, Pollock, Catherine, Martin, Philip, Owen, Andrew, Smyth, Thomas, Doherty, Declan, Campbell, Moray J., McClean, Stephen and Thompson, Paul (2012) Regulation of CYP3A4 and CYP3A5 expression and modulation of “intracrine” metabolism of androgens in prostate cells by liganded vitamin D receptor. Molecular and Cellular Endocrinology, TBC.

Chang, Chin-Kuo, Mulholland, HG, Cantwell, MM, Anderson, LA, Johnston, BT, McKnight, AJ, Thompson, Paul, Watson, RM and Murray, LJ (2011) Vitamin D Receptor Gene Variants and Esophageal Adenocarcinoma Risk: A Population-Based Case-Control Study. Journal of Gastrointestinal Cancer , Epub ahead of print. PMID:21948293.

Haussler, MR, Haussler, CA, Whitfield, GK, Hsieh, JC, Thompson, Paul, Barthel, TK, Bartik, L, Egan, JB, Wu, J, Kubicek, JL, Lowmiller, CL, Moffet, EW, Forster, RE and Jurutka, PW (2010) The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the "Fountain of Youth" to mediate healthful aging. J Steroid Biochem Mol Biol, 121 (1-2). pp. 88-97.

Lee , WP, Doherty , D, Furmick , J, Widener , T, Jurutka , P and Thompson, Paul (2010) Sentrin/SUMO Specific Proteases as Novel Tissue-Selective Co-Activator Proteins That Modulate Signalling by Vitamin D Receptor and Retinoid X Receptor Alpha. In: ENDO 2010 . The Endocrine Society. 13-13

Pollock, C, Maguire , O, Smyth , T, McClean, Stephen, Martin , P, Owen , A and Thompson, Paul (2010) Regulation of CYP3A4 and CYP3A5 Expression in Prostate Cells and Modulation of 'Intracrine' Metabolism of Androgens by Liganded Vitamin D Receptor (VDR). In: ENDO 2010 . The Endocrine Society. 63-63

Devlin, Andrea, Thompson, Paul, Robson, Tracy and McKeown, SR (2010) Cytochrome P450 1B1 mRNA Untranslated Regions Interact to Inhibit Protein Translation. Molecular Carcinogenesis, 49 (2). pp. 190-199.

Martin, P, Riley, R, Thompson, Paul, Williams, D, Back, D and Owen, A (2010) Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells. Acta Pharmacol Sin, 31 (1). pp. 51-65.

Green, CD, Thompson, Paul, Johnston, PG and El-Tanani, MK (2007) Interaction between transcription factor, basal transcription factor 3, and the NH2-terminal domain of human estrogen receptor alpha. Molecular Cancer Research, 5. pp. 1191-1200.

Jurutka, PW, Thompson, Paul, Whitfield, GK, Eichhorst, KR, Hall, N, Dominguez, CE, Hsieh, JC, Haussler, CA and Haussler, MR (2005) Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4. J Cell Biochem, 94 (5). pp. 917-943.

Otte, K, Kranz, H, Kober, I, Thompson, Paul, Hoefer, M, Haubold, B, Remmel, B, Voss, H, Kaiser, C, Albers, M, Cheruvallath, Z, Jackson , D, Casari, G, Koegl, M, Paabo , S, Mous, J, Kremoser, C and Deuschle, U (2003) Identification of FXR as a novel mammalian nuclear receptor sensing lanosterol . Biochemical and Biophysical Research Communications, 23 (3). pp. 864-872.

Hsieh, JC, Whitfield, GK, Jurutka, PW, Haussler, CA, Thatcher, ML, Thompson, Paul, Dang, HT, Gilligan, MA, Oza, AK and Haussler, MR (2003) Two basic amino acids C-terminal of the proximal box specify functional binding of the vitamin D receptor to its rat osteocalcin deoxyribonucleic acid-responsive element. . Endocrinology, 144. pp. 5065-5080.

Jurutka , PW, Thompson, Paul, Whitfield , GK, Myskowski , SM, Eichhorst , KR, Dominguez , CE, Haussler , CA and Haussler , MR (2002) Liganded VDR induces CYP3A4 via DR3 and ER6 VDREs: A potential mechanism for vitamin D-mediated cellular detoxification. In: Twenty-fourth Annual ASBMR Meeting. American Society for Bone and Mineral Research. Vol 17 S218-S218

Thompson, Paul, Jurutka, PW, Whitfield, G, Myskowski, SM, Eichhorst, KR, Encinas Dominguez , C, Haussler, CA and Haussler, MR (2002) Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements . Biochemical and Biophysical Research Communications, 20 (299). pp. 730-738.

Dominguez , CE, Jurutka , PW, Thompson, Paul, Hsieh , JC, Thatcher , ML, Haussler , CA, Whitfield , GK and Haussler , MR (2001) Insights into the biochemical life cycle of the vitamin D receptor. In: Twenty-third Annual ASBMR Meeting on October 12-16, 2001 in Phoenix, Arizona. For more information, please cont. American Society for Bone and Mineral Research.

Hsieh , JC, Dang , HTL, Galligan, MA, Whitfield, GK, Jurutka, PW, Thompson, Paul, Haussler , CA and Haussler , MR (2001) Phosphorylation of the human vitamin D receptor by protein kinase A downregulates 1,25(OH)(2)D-3-dependent transactivation by reducing retinoid X receptor beta heterodimerization. In: Twenty-third Annual ASBMR Meeting . American Society for Bone and Mineral Research. S231-S231

Jurutka , PW, Lamb , TL, Dominguez , CE, Whitfield , GK, Hsieh , JC, Thompson, Paul, Galligan , MA, Haussler , CA and Haussler , MR (2001) Molecular analysis of helix-1 and helix-3 in the human vitamin D receptor reveals functional subdomains mediating hormone binding, protein stabilization, heterodimerization and interaction with coactivators. In: Twenty-third Annual ASBMR Meeting . American Society for Bone and Mineral Research. Vol 16 S229-S229

Thompson, Paul, Myskowski , SM, Galligan , MA, Jurutka , PW, Chan , R, Whitfield , GK, Haussler , CA and Haussler , MR (2001) The 20-epi-1,25-dihydroxyvitamin D-3 analog KH1060: Deciphering the elusive mechanism for the enhanced transcriptional potency of this vitamin D receptor agonist. In: Twenty-third Annual ASBMR Meeting . American Society for Bone and Mineral Research. Vol 16 S553-S553

Jurutka, PW, MacDonald, PN, Nakajima, S, Hsieh, JC, Thompson, Paul, Whitfield, GK, Galligan, MA, Haussler, CA and Haussler, MR (2001) Isolation of baculovirus-expressed human vitamin D receptor: DNA responsive element interactions and phosphorylation of the purified receptor. J. Cell Biochem, 85. pp. 435-57.

Thompson, Paul, Remus, LS, Hsieh, JC, Jurutka, PW, Whitfield, GK, Galligan, MA, Encinas Dominguez, C, Haussler, CA and Haussler, MR (2001) Distinct Activation Function-2 (AF-2) Residues in RXR Determine Transactivation in the Context of VDR-RXR Heterodimers versus RXR-RXR Homodimers. Journal of Molecular Endocrinology, 27. pp. 211-227.

Jurutka , PW, Whitfield , GK, Hsieh, JC, Thompson, Paul, Haussler , CA and Haussler , MR (2001) Molecular nature of the vitamin D receptor and its role in regulation of gene expression. Reviews in Endocrine and Metabolic Disorders, 2 (2). pp. 203-216.

Hsieh , JC, Dang , HTL, Thompson, Paul, Galligan , MA, Whitfield , GK, Jurutka , PW, Oza , AK, Haussler , CA and Haussler , MR (2000) Arginine-49 in the zinc finger domain of the human vitamin D receptor determines hormone responsive element interaction. In: ASBMR 22nd Annual Meeting. American Society for Bone and Mineral Research. S234-S234

Jurutka, PW, Remus , LS, Whitfield, GK, Thompson, Paul, Hsieh, JC, Zitzer, H, Tavokkoli, P, Galligan, MA, Dang, HT, Haussler, CA and Haussler, MR (2000) The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. Mol Endocrinology, 14. pp. 401-420.

Hsieh, JC, Whitfield, GK, Oza, AK, Dang, HT, Price, JN, Galligan, MA, Jurutka, PW, Thompson, Paul, Haussler, CA and Haussler, MR (1999) Characterization of unique DNA-binding and transcriptional-activation functions in the carboxyl-terminal extension of the zinc finger region in the human vitamin D receptor. Biochemistry, 38. pp. 16347-16358.

Thompson, Paul, Hsieh, JC, Haussler, CA, Whitfield, GK, JB , Tillman, Spindler, SR and Haussler, MR (1999) VDR Binds DNA and Transactivates as a Dimeric Complex with RXR, but not with Thyroid Hormone Receptor (TR). J. Cell. Biochem, 75. pp. 462-480.

Haussler , MR, Whitfield , GK, Haussler , CA, Hsieh , JC, Thompson, Paul, Selznick , SH, Dominguez , CE and Jurutka, PW (1998) The nuclear vitamin D receptor: Biological and molecular regulatory properties revealed. Journal of Bone and Mineral Research, 13 (3). pp. 325-349.

Thompson, Paul, Jurutka, PW, Haussler, CA, Whitfield , GK and Haussler, MR (1998) R Heterodimeric DNA binding by the vitamin D receptor and retinoid X receptors is enhanced by 1,25-dihydroxyvitamin D3 and inhibited by 9-cis retinoic acid: Evidence for allosteric receptor interactions. Journal of Biological Chemistry, 273. pp. 8483-8491.

Haussler , MR, Haussler , CA, Jurutka , PW, Thompson, Paul, Hsieh , JC, Remus , LS, Selznick , SH and Whitfield , GK (1997) The vitamin D hormone and its nuclear receptor: molecular actions and disease states. Journal of Endocrinology , 154. pp. S57-S73.

Jurutka , PW, Hsieh , JC, Remus , LS, Whitfield , GK, Thompson, Paul, Haussler , CA, Blanco , JCG and Haussler , MR (1997) Mutations in the 1,25-dihydroxyvitamin D-3 receptor identifying C-terminal amino acids required for transcriptional activation that are functionally dissociated from hormone binding, heterodimeric DNA binding, and interaction with basal transcription factor IIB, in vitro. Journal of Biological Chemistry, 272 (23). pp. 14592-14599.

Whitfield , GK, Selznick , SH, Haussler , CA, Hsieh , JC, Galligan , MA, Jurutka , PW, Thompson, Paul, Lee, SM, Zerwekh , JE and Haussler , MR (1996) Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D-3: Point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X receptor heterodimeric partner. Molecular Endocrinology, 10 (12). pp. 1617-1631.

Whitfield , GK, Hsieh , JC, Nakajima , S, Macdonald , PN, Thompson, Paul, Jurutka , PW, Haussler , CA and Haussler , MR (1995) A HIGHLY CONSERVED REGION IN THE HORMONE-BINDING DOMAIN OF THE HUMAN VITAMIN-D-RECEPTOR CONTAINS RESIDUES VITAL FOR HETERODIMERIZATION WITH RETINOID-X-RECEPTOR AND FOR TRANSCRIPTIONAL ACTIVATION. Molecular Endocrinology, 9 (9). pp. 1166-1179.

Haussler , MR, Jurutka , PW, Hsieh , JC, Thompson, Paul, Selznick , SH, Haussler , CA and Whitfield, GK (1995) NEW UNDERSTANDING OF THE MOLECULAR MECHANISM OF RECEPTOR-MEDIATED GENOMIC ACTIONS OF THE VITAMIN-D HORMONE. Bone, 17 (2). pp. S33-S38.

Haussler , MR, Jurutka , PW, Hsieh , JC, Thompson, Paul, Selznick , SH, Haussler , CA and Whitefield , GK (1994) Receptor mediated genomic actions of 1,25(OH)(2)D-3: Modulation by phosphorylation. In: Vitamin D: Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, pp. 209-216. ISBN 3-11-014157-4

Thompson, Paul and Freisheim , JH (1991) CONVERSION OF ARGININE TO LYSINE AT POSITION 70 OF HUMAN DIHYDROFOLATE-REDUCTASE - GENERATION OF A METHOTREXATE-INSENSITIVE MUTANT ENZYME. Biochemistry, 30 (33). pp. 8124-8130.

Huang , SM, Appleman , JR, Tan , XH, Thompson, Paul, Blakley , RL, Sheridan , RP, Venkataraghavan , R and Freisheim , JH (1990) ROLE OF LYSINE-54 IN DETERMINING COFACTOR SPECIFICITY AND BINDING IN HUMAN DIHYDROFOLATE-REDUCTASE. Biochemistry, 29 (35). pp. 8063-8069.

Tan , XH, Huang , SM, Ratnam , M, Thompson, Paul and Freisheim , JH (1990) THE IMPORTANCE OF LOOP REGION RESIDUES 40-46 IN HUMAN DIHYDROFOLATE-REDUCTASE AS REVEALED BY SITE-DIRECTED MUTAGENESIS. Journal of Biological Chemistry, 265 (14). pp. 8027-8032.

Freisheim , JH , Huang , S, Prendergast , NJ, Tan, X, Smith , PL, Bullerjahn , AME, Delcamp, TJ, Thompson, Paul, Appleman , JR, Beard , WA, Tsay , JT and Blakley , RL (1989) MUTAGENESIS OF HUMAN DIHYDROFOLATE-REDUCTASE STRUCTURE AS A PROBE OF ENZYME FUNCTION. Chemistry and Biology of Pteridines 1989: Pteridines and Folic Acid Derivatives, NA. pp. 708-715.