Walsh, Colum Professor
Professor of Genetics
Academic and Professional Qualifications:
1995 Ph.D. Dept. Animal Genetics and Development, Uppsala University, Uppsala, Sweden.
1990 BA.(Honours) Natural Sciences II (Genetics), First Class. Trinity College, Dublin.
Nov 2005- present Group Leader, Stem Cells and Epigenetics Research Group
October 2002-present Senior Lecturer in Molecular Genetics, UU
Jan 1999- Sept. 2002 Lecturer in Molecular Genetics, University of Ulster at Coleraine, Northern Ireland, UK
August 1995-Dec. 1998 Awarded a Swedish Cancer Foundation post-doctoral fellowship (1996, renewed 1997) then a Leukemia Research Foundation fellowship (1998) to study the role of DNA methylation in transcriptional control with Dr. Tim Bestor, Dept. of Genetics and Development, Columbia University, New York.
August 1990- May 1995 Recipient of a PhD fellowship from the Karolinska Institute to study development and imprinting in the laboratory of Prof. Rolf Ohlsson and Dr. Gary Franklin. Ph.D. position transferred to Uppsala University with the lab in 1994. Worked June-August 1995 in a postdoctoral capacity.
June 1989-Oct. 1989 American-Irish foundation grant to with Prof. Ray Rodriguez at the Section of Molecular and Cellular Biology at the University of California, Davis
Walsh, Colum Professor/table>
Walsh, Colum Professor - Publications
Thakur, Avinash, Mackin, Sarah-Jayne, Irwin, Rachelle, O’Neill, Karla M., Pollin, Gareth and Walsh, Colum P (2016) Widespread recovery of methylation at gametic imprints in hypomethylated mouse stem cells following rescue with DNMT3A2. Epigenetics & Chromatin, 9 (53).
Lynch, Seodhna, O'Neill, Karla, McKenna, Michael, Walsh, Colum and McKenna, Declan (2016) Regulation of miR-200c and miR-141 by methylation in prostate cancer.. Ulster Medical Journal, 87 (1). pp. 11-12.
McElhatton, Niall, Walsh, Colum and McKenna, Declan (2016) The role of miR-210 in Prostate Cancer tumour development. Ulster Medical Journal, 87 (1). pp. 13-13.
Lynch, Seodhna, O'Neill, Karla M., McKenna, Michael M., Walsh, CP and McKenna, Declan J (2016) Regulation of miR-200c and miR-141 by methylation in prostate cancer. The Prostate, 2016.
Lynch, Seodhna M, McKenna, Michael M, Walsh, Colum and McKenna, Declan J (2016) miR-24 regulates CDKN1B/p27 expression in prostate cancer.. The Prostate, epub. pp. .
Irwin, Rachelle, Pentieva, Kristina, Cassidy, Tony, Lees Murdock, Diane, McLaughlin, Marian, Prasad, Girijesh, McNulty, Helene and Walsh, CP (2016) The interplay between DNA methylation, folate and neurocognitive development. Epigenomics.
Lynch, Seodhna, McKenna, Michael, Walsh, Colum and McKenna, Declan (2015) miR-24 regulates p27 expression in prostate cancer. Ulster Medical Journal, 84 (3). pp. 208-209.
Lynch, Seodhna, mckenna, michael, Walsh, Colum and McKenna, Declan (2015) miR-24 regulates p27 expression in prostate cancer. In: 2015 Keystone Symposia Conference E5: MicroRNAs and Noncoding RNAs in Cancer, Keystone, Colorado. Keystone Symposia.
Lynch, Seodhna, O'Neill, Karla, mckenna, michael, Walsh, Colum and McKenna, Declan (2015) Epigenetic regulation of miR-200c in prostate cancer. In: 2015 Keystone Symposia Conference E5: MicroRNAs and Noncoding RNAs in Cancer, Keystone, Colorado. Keystone Symposia.
Xu, Guo-Liang and Walsh, Colum (2014) Enzymatic DNA oxidation: mechanisms and biological significance. BMB Reports, 47 (11). pp. 609-618.
Xu, Guoliang and Walsh, CP (2014) Genomics Special Issue on 5-hydroxymethylation. Genomics, 104 (5). pp. 313.
Irwin, Rachelle and Walsh, CP (2014) 5-Hydroxymethylation marks a class of neuronal gene regulated by intragenic methylcytosine levels.. Genomics, 104 (5). pp. 383-92.
Walsh, Colum and Thakur, Avinash (2014) How to build your own island. eLife, 3.
Guo, Fan, Li, Xianlong, Liang, Dan, Li, Tong, Zhu, Ping, Guo, Hongshan, Wu, Xinglong, Wen, Lu, Gu, Tian-Peng, Hu, Boqiang, Walsh, Colum, Li, Jinsong, Tang, Fuchou and Xu, Guo-Liang (2014) Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote. Cell Stem Cell, 15 (4). pp. 447-458.
Lynch, Seodhna, O'Neill, Karla, McKenna, Michael, Walsh, Colum and McKenna, Declan (2014) Epigenetic Regulation of miRNA expression in prostate cancer. In: 6th Annual Translational Medicine Conference (TMED6 / C-TRIC),, Derry, UK. The Clinical Translational Research and Innovation Centre (C-TRIC). 33-34
Lynch, Seodhna, O'Neill, Karla, mckenna, michael, Walsh, Colum and McKenna, Declan (2014) EPIGENETIC REGULATION OF MICRORNA EXPRESSION IN PROSTATE CANCER. In: RNAi 2014: Short and Long Non-coding RNAs, St Hilda's College, Oxford, UK. Library Publishing Media.
Rutledge, Charlotte E., Lau, Ho-Tak, Mangan, Hazel, Hardy, Linda L., Sunnotel, Olaf, Guo, Fan, MacNicol, Angus M., Walsh, Colum and Lees Murdock, Diane (2014) Efficient Translation of Dnmt1 Requires Cytoplasmic Polyadenylation and Musashi Binding Elements. PLoS ONE, 9 (2). pp. e88385.
Courtney, DG, Atkinson, Sarah, Allen, EHA, Moore, Johnny, Walsh, CP, Leslie Pedrioli, DM, MacEwan, C, Pellegrini, G, Maurizi, E, Serafini, C, Fantacci, M, Liao, H, Irvine, AD, McLean, WHI and Moore, Tara (2014) siRNA Silencing of the Mutant Keratin 12 Allele in Corneal Limbal Epithelial Cells Grown from Patients with Meesmannâ€™s Epithelial Corneal Dystrophy. Invest Ophthalmol Vis Sci, 55 (5). pp. 3352-3360.
Rutledge, C. E., Thakur, A., O'Neill, Karla, Irwin, R. E., Sato, S., Hata, K. and Walsh, Colum (2014) Ontogeny, conservation and functional significance of maternally inherited DNA methylation at two classes of non-imprinted genes. Development, 141.
O'Doherty, Alan M., Rutledge, Charlotte E., Sato, Shun, Thakur, Avinash, Lees Murdock, Diane, Hata, Kenichiro and Walsh, Colum (2011) DNA methylation plays an important role in promoter choice and protein production at the mouse Dnmt3L locus. DEVELOPMENTAL BIOLOGY, 356 (2). pp. 411-420.
Loughery, JE, Dunne, PD, O'Nell, KM, Meehan, RR, McDaid, JR and Walsh, Colum (2011) DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage response. Human Molecular Genetics, 20 (16). pp. 3241-3255.
Sunnotel, Olaf, Walsh, Colum, Downes, Stephen, Hiripi, Laszlo, Robson, Tracy and Hirst, David (2010) Use of FKBPL gene to identify a cause of infertility.University of Ulster (2010) Use of FKBPL gene to identify a cause of infertility.
Sunnotel, Olaf, Walsh, Colum, Downes, Stephen and Lagan, Kevin (2010) Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study.. Reproductive Bioliogy and Endocrinology, 8 (22).
McDaid, J. R., Loughery, J., Dunne, P., Boyer, J. C., Downes, Stephen, Farber, R. A. and Walsh, Colum (2010) MLH1 mediates PARP-dependent cell death in response to the methylating agent N-methyl-N-nitrosourea (vol 101, pg 441, 2009). BRITISH JOURNAL OF CANCER, 102 (6). pp. 1080.
Rutledge, CER, Lees Murdock, Diane and Walsh, Colum (2010) DNA Methylation in Development. In: Encyclopedia of Life Sciences. Wiley, pp. 1-12. ISBN 9780470015902
McDaid, J. R., Loughery, J., Dunne, P., Boyer, J. C., Downes, Stephen, Farber, R. A. and Walsh, Colum (2009) MLH1 mediates PARP-dependent cell death in response to the methylating agent N-methyl-N-nitrosourea. BRITISH JOURNAL OF CANCER, 101 (3). pp. 441-451.
Lees Murdock, Diane, Lau, Ho-Tak, Castrillon, Diego H., De Felici, Massimo and Walsh, Colum (2008) DNA methyltransferase loading, but not de novo methylation, is an oocyte-autonomous process stimulated by SCF signalling. DEVELOPMENTAL BIOLOGY, 321 (1). pp. 238-250.
Lees Murdock, Diane and Walsh, Colum (2008) DNA methylation reprogramming in the germ line. EPIGENETICS, 3 (1). pp. 5-13.
Dobbin, E, Corrigan, PM, Walsh, Colum, Welham, MJ, Freeburn, RW and Wheadon, H (2008) Tel/PDGFRbeta inhibits self-renewal and directs myelomonocytic differentiation of ES cells. Leukaemia Research, 32 (10). pp. 1554-1546.
Lees Murdock, Diane and Walsh, Colum (2008) DNA methylation reprogramming in the germ line. In: GENOMIC IMPRINTING. Springer Science + Business Media, LLC, New York, pp. 1-15. ISBN 9780387775753
Shovlin, T. C., Bourc'his, D., La Salle, S., O'Doherty, A., Trasler, J. M., Bestor, T. H. and Walsh, Colum (2007) Sex-specific promoters regulate Dnmt3L expression in mouse germ cells. HUMAN REPRODUCTION, 22 (2). pp. 457-467.
Li, Ya-Qiang, Zhou, Ping-Zhu, Zheng, Xiu-Dan, Walsh, Colum and Xu, Guo-Liang (2007) Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair. NUCLEIC ACIDS RESEARCH, 35 (2). pp. 390-400.
Walsh, Colum and Xu, GL (2006) Cytosine methylation and DNA repair. In: DNA METHYLATION: BASIC MECHANISMS. Springer-Verlag, Heidelberg, pp. 283-315. ISBN 9783540291145
Lees Murdock, Diane and Walsh, Colum (2006) Developmental regulation of DNA methyltransferases. In: Encyclopedia of Genetics, Genomics, Proteomics & Bioinformatics. Wiley, pp. 1-10. ISBN 9780470011539
Wheadon, H, Freeburn, RW, Walsh, Colum and Welham, MJ (2005) Regulated expression of the Tel/PDGFR beta tyrosine kinase drives mouse embryonic stem cell differentiation in the presence of leukaemia inhibitory factor. In: 45th Annual Scientific Meeting of the British-Society-for-Haematology, Manchester, ENGLAND. Blackwell. Vol 129 (1), 246
Lees Murdock, Diane, Shovlin, TC, Gardiner, T, De Felici, M and Walsh, CP (2005) DNA methyltransferase expression in the mouse germ line during periods of de novo methylation. DEVELOPMENTAL DYNAMICS, 232 (4). pp. 992-1002.
Li, JY, Lees Murdock, Diane, Xu, GL and Walsh, Colum (2004) Timing of establishment of paternal methylation imprints in the mouse. GENOMICS, 84 (6). pp. 952-960.
Lees Murdock, Diane, McLoughlin, GA, McDaid, JR, Quinn, LM, O'Doherty, A, Hiripi, L, Hack, Catherine and Walsh, CP (2004) Identification of 11 pseudogenes in the DNA methyltransferase gene family in rodents and humans and implications for the functional loci. GENOMICS, 84 (1). pp. 193-204.
Lees Murdock, Diane, De Felici, M and Walsh, CP (2003) Methylation dynamics of repetitive DNA elements in the mouse germ cell lineage. GENOMICS, 82 (2). pp. 230-237.
Lynch, Catherine A, Tycko, Benjamin, Bestor, Timothy H and Walsh, Colum (2002) Reactivation of a silenced H19 gene in human rhabdomyosarcoma by altering DNA methylation, but not histone acetylation. Molecular Cancer, 1 (1). pp. 2.
Dao, D, Walsh, CP, Yuan, L, Gorelov, D, Feng, L, Hensle, T, Nisen, F, Yamashiro, DJ, Bestor, TH and Tycko, B (1999) Multipoint analysis of human chromosome 11p15 mouse distal chromosome 7: inclusion of H19/IGF2 in the minimal WT2 region, gene specificity of H19 silencing in Wilms' tumorigenesis and methylation hyper-dependence of H19 imprinting. HUMAN MOLECULAR GENETICS, 8 (7). pp. 1337-1352.
Bestor, TH, Walsh, Colum and Yoder, JA (1999) Gene silencing in mammalian gametogenesis. DEVELOPMENTAL BIOLOGY, 210 (1). pp. 255.
Walsh, CP and Bestor, TH (1999) Cytosine methylation and mammalian development. GENES & DEVELOPMENT, 13 (1). pp. 26-34.
Walsh, CP, Chaillet, JR and Bestor, TH (1998) Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. NATURE GENETICS, 20 (2). pp. 116-117.
Dao, D, Frank, D, Qian, NF, O'Keefe, D, Vosatka, RJ, Walsh, CP and Tycko, B (1998) IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes. HUMAN MOLECULAR GENETICS, 7 (4). pp. 597-608.
He, LM, Cui, HM, Walsh, Colum, Mattsson, R, Lin, WL, Anneren, G, Pfeifer-Ohlsson, S and Ohlsson, R (1998) Hypervariable allelic expression patterns of the imprinted IGF2 gene in tumor cells. ONCOGENE, 16 (1). pp. 113-119.
Miller, SJ, Ulleras, E, Moncrieff, CL, Walsh, Colum, Adam, GIR and Franklin, GC (1998) A novel type of regulatory element is required for promoter-specific activity of the PDGF-B intronic enhancer region. GROWTH FACTORS, 16 (2). pp. 137-151.
Bestor, TH, Walsh, CP and Yoder, JA (1997) Does DNA methylation control transposition of selfish elements in the germline? Reply. TRENDS IN GENETICS, 13 (12). pp. 470-472.
Qian, N, Frank, D, OKeefe, D, Dao, D, Zhao, L, Yuan, L, Wang, Q, Keating, M, Walsh, Colum and Tycko, B (1997) The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis. HUMAN MOLECULAR GENETICS, 6 (12). pp. 2021-2029.
Yoder, JA, Walsh, CP and Bestor, TH (1997) Cytosine methylation and the ecology of intragenomic parasites. TRENDS IN GENETICS, 13 (8). pp. 335-340.
Yoder, JA, Walsh, Colum and Bestor, TH (1996) Control of cytosine methylation and retrovirus silencing in early development. In: American Society of Cell Biology, Bethesda. Amer Soc Cell Biology. Vol 7 (S), 47
SVENSSON, K, Walsh, Colum, FUNDELE, R and OHLSSON, R (1995) H19 IS IMPRINTED IN THE CHOROID-PLEXUS AND LEPTOMENINGES OF THE MOUSE FETUS. MECHANISMS OF DEVELOPMENT, 51 (1). pp. 31-37.
Walsh, Colum, MILLER, SJ, FLAM, F, FISHER, RA and OHLSSON, R (1995) PATERNALLY DERIVED H19 IS DIFFERENTIALLY EXPRESSED IN MALIGNANT AND NONMALIGNANT TROPHOBLAST. CANCER RESEARCH, 55 (5). pp. 1111-1116.
Walsh, Colum (1995) The characteristics of imprinted gene expression during human and mouse development. Almqvist and Wiksell International. Stockholm. 69 pp ISBN 9155435300
Ohlsson, R, Ekstrom, T, Franklin, G, Pfeifer-Ohlsson, S, Cui, H, Miller, S, Fisher, RA and Walsh, Colum (1995) The plasticity of imprinting. In: Genomic imprinting: causes & consequences (Nobel Symposium 1994). Cambridge University Press, Cambridge, pp. 182-194. ISBN 0521472431
Walsh, Colum, GLASER, A, FUNDELE, R, FERGUSONSMITH, A, BARTON, S, SURANI, MA and OHLSSON, R (1994) THE NON-VIABILITY OF UNIPARENTAL MOUSE CONCEPTUSES CORRELATES WITH THE LOSS OF THE PRODUCTS OF IMPRINTED GENES. MECHANISMS OF DEVELOPMENT, 46 (1). pp. 55-62.
OHLSSON, R, HEDBORG, F, HOLMGREN, L, Walsh, Colum and EKSTROM, TJ (1994) OVERLAPPING PATTERNS OF IGF2 AND H19 EXPRESSION DURING HUMAN-DEVELOPMENT - BIALLELIC IGF2 EXPRESSION CORRELATES WITH A LACK OF H19 EXPRESSION. DEVELOPMENT, 120 (2). pp. 361-368.