Molecular & Translational Medicine Research Group

Publications

Number of items: 65.

McClean, Paula, Parthsarathy, Vadivel, Faivre, Emilie and Holscher, Christian (2011) The diabetes drug Liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. . The Journal of Neuroscience, 31 (17). pp. 6587-6594.

Hamilton, Alison, Patterson, Steven, porter, David, Gault, Victor A and Holscher, Christian (2011) Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain. J Neurosci Res, 89. pp. 481-489.

faivre, Emilie, Gault, Victor, thorens, Bernard and Holscher, Christian (2011) Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis. J Neurophysiol, 89. pp. 481-489.

Holscher, Christian (2011) Protective roles of the incretin hormones Glucagon-Like Peptide-1 and Glucose-dependent Insolinotropic Polypeptide hormones in neurodegeneration. In: Alzheimer's disease. InTech publishing, pp. 123-184. ISBN ISBN
978-953-307-466-5

Porter, D. W., Kerr, B. D., Flatt, Peter, Holscher, Christian and Gault, Victor (2010) Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance. DIABETES OBESITY & METABOLISM, 12 (10). pp. 891-899.

Hunter, Kerry, O'Harte, FPM, Abdel-Wahab, YHA and Flatt, PR (2010) Evaluation of the inhibitory action of islet amyloid polypeptide on insulin secretion from clonal rat pancreatic beta-cells. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 44.

Porter, W. D., Kerr, B. D., Flatt, Peter, Holscher, Christian and Gault, Victor (2010) The glucagon-like peptide-1 agonist Liraglutide improves memory and learning in obese-diabetic mice. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 40.

Irwin, Nigel, Porter, W. D., Flatt, Peter, Holscher, Christian and Gault, Victor (2010) Prolonged GIP receptor activation improves glucose homeostasis and cognitive function in high-fat fed mice. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 44.

McClean, Paula, Parthsarathy, V., Faivre, E. and Holscher, Christian (2010) The novel GLP-1 analogue liraglutide has neuroprotective properties in a mouse model of Alzheimer's disease. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 40.

McClean, Paula, Gault, Victor A, Harriott, Patrick and Holscher, Christian (2010) Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease. EUROPEAN JOURNAL OF PHARMACOLOGY, 630 (1-3). pp. 158-162.

Porter, David, Irwin, Nigel, Flatt, Peter, Holscher, Christian and Gault, Victor (2010) Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high fat fed mice. Eur J Pharmacol, 650. pp. 688-693.

Wang, xiao-Hui, li, Lin, Holscher, Christian, Pan, Yan-Fang, Chen, Xiao-Rong and Qi, Jin-Shun (2010) Val8-GLP-1 Protects Against Aß1-40-Induced Impairment of Hippocampal Late-Phase Long-Term Potentiation and Spatial Learning in Rats. . Neuroscience, 170. pp. 1239-1248.

Gengler, Simon, Hamilton, Alison and Holscher, Christian (2010) Synaptic plasticity in the hippocampus of a APP/PS1 mouse model of Alzheimer’s disease is impaired in old but not young mice. PLoS ONE, 000.

Fendt, M, Bürki, H, Imobersteg, S, van der Putten, H, McAllister, K, Leslie, Julian, Shaw, D and Holscher, Christian (2010) The effect of mGlu(8) deficiency in animal models of psychiatric diseases.. Genes, brain, and behavior, 9. pp. 33-44.

McArt, DG, McKerr, George, Saetzler, Kurt, Howard, Vyvyan, Downes, Stephen and Wasson, GR (2010) Comet sensitivity in assessing DNA damage and repair in different cell cycle stages. Mutagenesis, 25 (3). pp. 299.

Gengler, Simon, McClean, Paula, McCurtin, Ruth, Gault, Victor and Holscher, Christian (2010) Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. Neurobiol Aging, 000. pp. 000-000.

Holscher, Christian and Li, Lin (2010) New roles for insulin-like hormones in neuronal signalling and protection: new hopes for novel treatments of Alzheimer’s Disease?. Neurobiol Aging, 31 (9). pp. 1495-1502.

Holscher, Christian (2010) Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease. Recent Patents on CNS Drug Discovery, 5. pp. 109-117.

Holscher, Christian (2010) Höhere Verarbeitungsprozesse. In: Taschenlehrbuch Biologie, Zoologie. Thieme Verlag, pp. 551-584. ISBN ISBN 978-3-13-144841-5

Holscher, Christian (2010) The role of GLP-1 in neuronal activity and neurodegeneration. In: Vitamins and Hormones: INCRETINS AND INSULIN SECRETION. Academic Press/Elsevier, pp. 331-354. ISBN ISBN: 978-0-12-381517-0

Holscher, Christian, Fung, K., McCurtin, R., Gault, Victor and McClean, Paula (2009) Novel GLP-1 analogues cross the blood brain barrier and enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease. DIABETOLOGIA, 52 (Suppl. 1). pp. 790.

Hamilton, Alison and Holscher, Christian (2009) Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system. Neuroreport, 20. pp. 1161-1166.

Zhang, Huaizhong, Rodriguez, E. Patricia, Morrow, Philip, McClean, Sally and Saetzler, Kurt (2009) MCMC-based algorithm to adjust scale bias in large series of electron microscopical ultrathin sections. In: Proceedings of the 13th International Conference on Computer Analysis of Images and Patterns. . 557-564

McArt, Darragh G, McKerr, G, Howard, Vyvyan, Saetzler, Kurt and Wasson, Gillian R (2009) Modelling the comet assay. Biochemical Society Transactions, 037 (4). pp. 914-917.

Abbas, Talib, Faivre, Emilie and Holscher, Christian (2009) Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease.. Behavioural brain research, 205 (1). pp. 265-71.

Li, Lin, Li, Yan-wei, Zhao, Jin-ying, Liu, Yue-Ze and Holscher, Christian (2009) Quantitative analysis of iron concentration and expression of ferroportin 1 in the cortex and hippocampus of rats induced by cerebral ischemia.. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 16 (11). pp. 1466-72.

Saetzler, Kurt, McCanny, P., Rodriguez, E.P., and R.M. Bruno, H. Horstmann and Denk, W. (2009) A fuzzy algorithm to trace stained neurons in serial block-face scanning electron microscopy image series. In: 13th International Machine Vision and Image Processing Conference, Dublin. . 162-167

Wang, Hongjuan, Wang, Rong, Zhao, Zhiwei, Ji, Zhijuan, Xu, Shiming, Holscher, Christian and Sheng, Shuli (2009) Coexistences of insulin signaling-related proteins and choline acetyltransferase in neurons.. Brain research, 1249. pp. 237-43.

McClean, Paula, Gault, Victor, Harriott, Patrick and Holscher, Christian (2009) Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease.. European journal of pharmacology, epub.

Zhang, Huaizhong, Morrow, PJ, McClean, S and Saetzler, Kurt (2008) Contour detection of labeled cellular structures from serial ultrathin electron microscopy sections using GAC and prior analysis. In: IEEE Proceedings of IPTA'08. . 317-323

Guerreiro-Lucas, Luciano A, Pop, S. Rares, Ma, Maria J C Machado and Ying Liang, Waters, Sarah L, Richardson, Giles, Saetzler, Kurt, Jensen, Oliver E and Mitchell, Christopher (2008) Experimental and theoretical modelling of blind-ended vessels within a developing angiogenic plexus.. Microvasc Res, 76. pp. 161-168.

Ma, YingLiang and Saetzler, Kurt (2008) A Parallelized Surface Extraction Algorithm for Large Binary Image Data Sets Based on an Adaptive 3-D Delaunay Subdivision Strategy. IEEE Transactions on Visualization and Computer Graphics, 14 (1). pp. 160-172.

Gault, Victor A and Holscher, Christian (2008) Protease-resistant glucose-dependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid.. Journal of neurophysiology, 99 (4). pp. 1590-5.

Gault, Victor and Holscher, Christian (2008) GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid.. European journal of pharmacology, 587 (1-3). pp. 112-7.

Holscher, Christian and Li, Lin (2008) New roles for insulin-like hormones in neuronal signalling and protection: New hopes for novel treatments of Alzheimer's disease?. Neurobiology of Aging, epub.

Holscher, Christian, van Aalten, Lidy and Sutherland, Calum (2008) Anaesthesia generates neuronal insulin resistance by inducing hypothermia.. BMC neuroscience, 9. pp. 100.

Ma, Y.L., Rhode, K.S., Razavi, R. and Saetzler, Kurt (2008) Real-Time Visualization of Cardiac Catheterization Procedures Based on a New Algorithm for Reconstructions from Planar Cross Sections Using the Unconstrained 3D Delaunay Triangulation. In: Proc. International Machine Vision and Image Processing Conference IMVIP '08, Coleraine. . 142-147

Ma, Ying Liang, Rhode, Kawal S., King, Andy P., Phani Chinchapatnam, Gang Gao, Schaeffter, Tobias, Razavi, Reza and Saetzler, Kurt (2008) Time-varying Image Data Visualization Framework for Application in Cardiac Catheterization Procedures. In: Theory and Practice of Computer Graphics, Manchester. . 137-140

Holscher, Christian (2008) Functional roles of Theta and Gamma oscillations in the association and dissociation of neuronal networks in primates and rodents. In: Information Processing by Neuronal Populations. (Eds: Holscher, Christian and Munk, M), Cambridge University Press, pp. 151-173. ISBN ISBN 978-0-521-87303-1

Holscher, Christian (2008) How could populations of neurons encode information?. In: Information Processing by Neuronal Populations. (Eds: Holscher, Christian and Munk, M), Cambridge University Press, pp. 3-20. ISBN ISBN 978-0-521-87303-1

Holscher, Christian and Munk, M, eds. (2008) Mechanisms of information processing in the Brain: Information Processing by Neuronal Population. 666 pp. Cambridge University Press. ISBN ISBN 978-0-521-87303-1

Morrow, PJ and Saetzler, Kurt (2007) Validation of in vivo Leukocyte Velocity Estimates via Modeling and Simulation. In: Conference Record of the Forty-First Asilomar Conference on Signals, Systems and Computers ACSSC 2007, Pacific Groove. . 1288-1292

Bigot, S., Lucas, L., Morrow, PJ, Mitchell, Christopher and Saetzler, Kurt (2007) Estimating leukocyte velocities from high-speed 1D line scans oriented orthogonal to blood flow. In: Biomedical Imaging: Macro to Nano, 2007. 4rd IEEE International Symposium on, Washington. . 376-379

Li, Lin and Holscher, Christian (2007) Common pathological processes in Alzheimer disease and type 2 diabetes: a review.. Brain research reviews, 56 (2). pp. 384-402.

Rollenhagen, Astrid, Saetzler, Kurt, Rodriguez, Peter, Frotscher, Michael and Lübke, Joachim H. R. (2007) Structural Determinants of Transmission at Large Hippocampal Mossy Fiber Synapses. J. Neurosci., 27 (39). pp. 10434-10444.

Zhang, Huaizhong, Morrow, Philip, McClean, Sally and Saetzler, Kurt (2007) Incorporating Feature Based Priors into the Geodesic Active Contour Model and its Application in Biomedical Imagery. In: Proc. of the International Machine Vision and Image Processing Conference, 2007. IMVIP 2007.. . 67-74

Gengler, Simon, Gault, Victor, Harriott, Peter and Holscher, Christian (2007) Beta-amyloid (25-35) induced impairments of hippocampal synaptic plasticity are dependent on stimulation-protocol, genetic background, and aggregation state. Exp Brain Res, 179. pp. 621-632.

McEnery, O., Lucas, L., Ma, YingLiang, Morrow, PJ, Mitchell, Christopher and Saetzler, Kurt (2006) A fast, robust and scale-independent approach to estimate vessel diameters in intravital fluorescence microscopy images. In: Biomedical Imaging: Macro to Nano, 2006. 3rd IEEE International Symposium on. . 101-104

Radde, R, Bolmont, T, Käser, SA, Coomaraswamy, J, Lindau, D, Stoltze, L, Calhoun, ME, Jäggi, F, Wolburg, H, Gengler, S, Haass, C, Ghetti, B, Czech, C, Holscher, Christian, Mathews, PM and Jucker, M (2006) Aß42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Reports, 7. pp. 940-946.

Holscher, Christian, Schmid, S, Pilz, P, van der Putten, H and Plappert, C (2005) Lack of the metabotropic glutamate receptor subtype 7 selectively modulates theta rhythm and working memory. Learning and Memory, 12. pp. 450-455.

Holscher, Christian (2005) Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies. Reviews in the Neurosciences, 16. pp. 181-212.

Saetzler, Kurt, Söhl, Leander F, Bollmann, Johann H, Borst, J. Gerard G, Frotscher, Michael, Sakmann, Bert and Lübke, Joachim H R (2002) Three-dimensional reconstruction of a calyx of Held and its postsynaptic principal neuron in the medial nucleus of the trapezoid body.. J Neurosci, 22 (24). pp. 10567-10579.

Saetzler, Kurt (2001) 3-D Rekonstruktion von Serienschnitten. In: Forschung und wissenschaftliches Rechnen, Beiträge zum Heinz-Billing-Preis 2000. (Eds: Plesser, T. and Hayd, H.), GWDG, pp. 31-47. ISBN 0176-2516

Grabenbauer, M., Saetzler, Kurt, Baumgart, E. and Fahimi, H.D. (2000) Three-dimensional ultrastructural analysis of peroxisomes in HepG2 cells: Absence of a peroxisomal reticulum but evidence of close spatial association with the endoplasmic reticulum.. Cell. Biochem. Biophys., 32. pp. 37-49.

Saetzler, Kurt (2000) 3D Rekonstruktion von Serienschnitten mit CAR.

Saetzler, Kurt (2000) 3D--Rekonstruktion von elektronenmikroskopischen Serienschnitten.

Eils, R. and Saetzler, Kurt (1999) Shape Reconstruction from Volumetric Data. In: Handbook of Computer Vision and Applications. (Eds: Jähne, B., Haußecker, H. and Geißler, P.), Academic Press, San Diego, London, Boston, New York, Sydney, Tokyo, Toronto, pp. 791-815. ISBN 0123797705

Eils, R., Saracoglu, K. and Saetzler, Kurt (1999) Morphological parameters, medial lines and skeletons computed in the 3D--Voronoi diagram with applications to 3D CLSM images. In: Focus on Multidimensional Microscopy. (Eds: Cheng, P.C., Hwang, P.P., Wu, J.L., Wang, G. and Kim, H.), World Scientific Publishing, Singapore, pp. 34-56. ISBN 9810239920

Dietzel, S., Eils, R., Saetzler, Kurt, Bornfeld, H., Jauch, A., Cremer, C. and Cremer, T. (1998) Evidence against a looped structure of the inactive human X--chromosome territory. Exp. Cell Res, 240 (2). pp. 187-196.

Bornfleth, H., Saetzler, Kurt, Elis, R. and Cremer, C. (1998) High-precision distance measurements and volume-conserving segmentation of objects near and below the resolution limit in three-dimensional confocal fluorescence microscopy. Journal of Microscopy, 189. pp. 118-136.

Eils, R., Uhrig, S., Saetzler, Kurt, Saracoglu, K., Chassery, A. Bolzer and J.-M., Ganser, M. and Speicher, M.R. (1998) An optimized and fully automated system for fast and accurate identification of chromosomal rearrangements my multiplex-FISH (M-FISH). Cell Genetics and Cytogenetics, 82. pp. 160-171.

Saetzler, Kurt and Eils, R. (1997) Resolution improvement by 3-D reconstructions from tilted views in axial tomography and confocal theta microscopy. Bioimaging, 5. pp. 171-182.

Bornfleth, H., Zink, D., Saetzler, Kurt, Eils, R. and Cremer, C. (1996) Modellgestützte Segmentierung von Replikationsdomänen in dreidimensionalen konfokalen Mikroskopiebildern. In: Mustererkennung 1996. . 408-419

Saetzler, Kurt, Cremer, Cornelius and Eils, Roland (1996) 3D-Bildfolgen zur Auflösungsverbesserung in der Fluoreszenzmikroskopie. In: Mustererkennung 1996, 18. DAGM-Symposium. . 92-105

Eils, R., Saracoglu, K., Münkel, C., Imhoff, J., Saetzler, Kurt, Dietzel, S., Schröck, E., Ried, T., Cremer, T. and Cremer, C. (1995) Three--dimensional imaging approaches and Monte Carlo simulations: development of tools to study the morphology and distribution of chromosome territories and subchromosomal targets in human cell nuclei. In: Zoological Studies. . 7-10

This list was generated on Fri Apr 18 15:33:49 2014 BST.