Nano Systems Biology
  1. Background
  2. Contact
  3. Publications

Dr George McKerr

Senior Lecturer

Brief profile

Dr McKerr is a zoologist and parasitologist who graduated with a BSc in Zoology from Queen’s University Belfast in 1976 and was appointed as a Lecturer in Biology at the Ulster Polytechnic, Jordanstown, before obtaining a PhD in Parasitology from Queen’s in 1985.

In 1984, he was appointed as a Lecturer in Microscopy at the University of Ulster and later promoted to his current position as Senior Lecturer in Microscopy, where he is presently directing the new FEI Centre for Advanced Imaging recently launched by the University of Ulster.

Over the years, George has developed many in house instruments to aid in single molecule spectroscopy, single receptor site pharmacology (as measured by functionalised AFM and combined confocal fluorescence), optical measurements of DNA damage and cryo-dualbeam electron microscopy. Coleraine was the site where the first automated comet analysis system was devised (in conjunction with Kinetic Imaging now Andor Bioimaging). The BRG has several collaborations with instrument manufacturers and its FEI Centre for Advanced Imaging is the first to be equipped with the cryo-dualbeam microscope technology.

Research interests

George’s main research interests are: microscopy tumour biology cell ion signalling developmental neurobiology single receptor site pharmacology neuroregeneration in primitive animals atomic force imaging of the living cell surface.

Dr George McKerr

space

Dr G McKerr
Senior Lecturer
Biomedical Sciences Research Institute

space

Room W0042
School of Biomedical Sciences
University of Ulster
Coleraine campus
Cromore Road
Coleraine
Co. Londonderry
BT52 1SA

phone: +44 28 70124759
Email: g.mckerr@ulster.ac.uk

Dr George McKerr - Publications

Number of items: 26.

Barnes, Clifford, McKerr, George, Soto, A. M., Downes, Stephen and Howard, Vyvyan (2014) From Single Cells to Tissues: Interactions between the Matrix and Human Breast Cells in Real Time. PLOS ONE, 9 (4). pp. 1-12.

McGlynn, Angela P, Wasson, Gillian R, O'Reilly, Sharleen R, McNulty, Helene, Downes, C. Stephen, Chang, Chin-Kuo, Hoey, Leane, Molloy, Anne M, Ward, Mary, Strain, JJ, McKerr, George, Weir, Donald G and Scott, John M (2013) Low Colonocyte Folate Is Associated with Uracil Misincorporation and Global DNA Hypomethylation in Human Colorectum. Journal of Nutrition, 143.

Martinho, Paulo N, Ortin, Yannick, Gildea, Brendan, Gandolfi, Claudio, McKerr, George, O'Hagan, Barry, Albrecht, Martin and Morgan, Grace G (2012) Inducing hysteretic spin crossover in solution.. Dalton transactions (Cambridge, England : 2003), 1.

Park, Margriet V. D. Z., Verharen, Henny W., Zwart, Edwin, Hernandez, Lya G., van Benthem, Jan, Elsaesser, Andreas, Barnes, Clifford, McKerr, George, Howard, Vyvyan, Salvati, Anna, Lynch, Iseult, Dawson, Kenneth A. and de Jong, Wim H. (2011) Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmidlacZgene mutation assay. Nanotoxicology, 5 (2). pp. 168-181.

Hazekamp, J, Doherty, S, Elsaesser, A, Barnes, Clifford, O'Hagan, Barry, McKerr, George and Howard, Vyvyan (2011) Focussed ion beam milling at grazing incidence angles.. Journal of microscopy, 242 (1). pp. 104-10.

Elsaesser, Andreas, Barnes, Clifford A, McKerr, George, Salvati, Anna, Lynch, Iseult, Dawson, Kenneth A and Howard, Vyvyan (2011) Quantification of nanoparticle uptake by cells using an unbiased sampling method and electron microscopy.. Nanomedicine (London, England), 6 (7). pp. 1189-98.

McArt, DG, McKerr, George, Saetzler, Kurt, Howard, Vyvyan, Downes, Stephen and Wasson, GR (2010) Comet sensitivity in assessing DNA damage and repair in different cell cycle stages. Mutagenesis, 25 (3). pp. 299.

McCoy, F, Hurwitz, J, McTavish, N, Paul, I, Barnes, Clifford, O'Hagan, Barry, Odrzywol, K, Murray, J, Longley, D, McKerr, George and Fennell, D A (2010) Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK. Cell Death and Disease, 1 (12). pp. e108.

Elsaesser, Andreas, Taylor, Ashley, Staats, Gesa, McKerr, George, Kim, Eun-Mee, O’Hare, Eugene and Howard, Vyvyan (2010) Quantification of nanoparticle uptake by cells using microscopical and analytical techniques. Nanomedicine, 5 (9). pp. 1447-1457.

Lamers, Edwin, Walboomers, X Frank, Domanski, Maciej, McKerr, George, O'Hagan, Barry, Barnes, Clifford, Peto, Lloyd, Luttge, Regina, Winnubst, Louis A J A, Gardeniers, Han J G E and Jansen, John A (2010) Cryo DualBeam Focused Ion Beam-Scanning Electron Microscopy to Evaluate the Interface Between Cells and Nanopatterned Scaffolds.. Tissue engineering. Part C, Methods, 17 (1). pp. 1-7.

Park, Margriet VDZ, Annema, Wijtske, Salvati, Anna, Lesniak, Anna, Elsaesser, Andreas, Barnes, Clifford, McKerr, George, Howard, Vyvyan, Lynch, Iseult, Dawson, Kenneth A, Piersma, Aldert H and de Jong, Wim H (2009) In vitro developmental toxicity test detects inhibition of stem cell differentiation by silica nanoparticles. TOXICOLOGY AND APPLIED PHARMACOLOGY, 240 (1). pp. 108-116.

McCoy, Francis, Hurwitz, Jane, Chacko, Alex D, Paul, Ian, Liberante, Fabio, O'Hagan, Barry, McKerr, George, Johnston, Patrick and Fennell, Dean A (2009) Resistance to the BH3 peptidomimetic obatoclax in non-small cell lung cancer associated with a block in BCL-2 family post-translational regulation. JOURNAL OF THORACIC ONCOLOGY, 4 (9, Suppl. 1). pp. S592.

Van Hoecke, Karen, Quik, Joris TK, Mankiewicz-Boczek, Joanna , De Schamphelaere, Karel AC, Elsaesser, Andreas, Van der Meeren, Paul, Barnes, Clifford, McKerr, George, Howard, Vyvyan, Van De Meent, Dik, Rydznyski, Konrad, Dawson, Kenneth, Salvati, Anna, Lynch, Iseult, Silversmit, Geert, De Samber, Bjorn , Vincze, Laszlo and Janssen, Colin R (2009) Fate and Effects of CeO2 Nanoparticles in Aquatic Ecotoxicity Tests. Environmental Science Technology, 43 (12). pp. 4537-4546.

McKerr, George and McKerr, Lynne (2009) ABA - what's the name of the game?. PSYCHOLOGIST, 22 (2). pp. 90-91.

McArt, Darragh G, McKerr, G, Howard, Vyvyan, Saetzler, Kurt and Wasson, Gillian R (2009) Modelling the comet assay. Biochemical Society Transactions, 037 (4). pp. 914-917.

McArt, Darragh G, Wasson, Gillian R, McKerr, George, Saetzler, Kurt, Reed, Matt and Howard, Vyvyan (2009) Systematic random sampling of the comet assay. Mutagenesis, 24 (4). pp. 373-378.

Barnes, Clifford, O'Hagan, Barry, Howard, Vyvyan and McKerr, G (2007) Verification of cell viability at progressively higher scanning forces using a hybrid atomic force and fluorescence microscope.. Journal of microscopy, 228 (Pt 2). pp. 185-9.

Wasson, Gillian R, McGlynn, Angela P, McNulty, Helene, O'Reilly, Sharleen L, McKelvey-Martin, Valerie, McKerr, George, Strain, JJ, Scott, John and Downes, Stephen (2006) Global DNA and p53 region-specific hypomethylation in human colonic cells is induced by folate depletion and reversed by folate supplementation. JOURNAL OF NUTRITION, 136 (11). pp. 2748-2753.

O'Hagan, Barry, Doyle, P, Allen, James, Sutton, K and McKerr, George (2004) The effects of atomic force microscopy upon nominated living cells. ULTRAMICROSCOPY, 102 (1). pp. 1-5.

O'Hagan, Barry, Doyle, Peter, Allen, James M, Sutton, Kerry and McKerr, G (2004) The effects of atomic force microscopy upon nominated living cells.. Ultramicroscopy, 102 (1). pp. 1-5.

McGlynn, AP, Wasson, GR, O'Reilly, S, McKelvey-Martin, Valerie, McNulty, Helene, Strain, JJ, McKerr, George, Mullan, F, Mahmud, N, Scott, J, Weir, DG and Downes, Stephen (2003) Detection of replicative integrity in small colonic biopsies using the BrdUrd comet assay. BRITISH JOURNAL OF CANCER, 88 (6). pp. 895-901.

McKenna, Declan J, Rajah, NF, McKeown, Stephanie, McKerr, George and McKelvey-Martin, Valerie (2003) Use of the comet-FISH assay to demonstrate repair of the TP53 gene region in two human bladder carcinoma cell lines. RADIATION RESEARCH, 159 (1). pp. 49-56.

Zhao, XJ, McKerr, George, Dong, Z, Higgins, CA, Carson, J, Yang, ZQ and Hannigan, BM (2001) Expression of oestrogen and progesterone receptors by mast cells alone, but not lymphocytes, macrophages or other immune cells in human upper airways. THORAX, 56 (3). pp. 205-211.

Smith, AG and McKerr, George (2000) Tritiated thymidine ([H-3]-TdR) and immunocytochemical tracing of cellular fate within the asexually dividing cestode Mesocestoides vogae (syn. M-corti). PARASITOLOGY, 121 (Part 1). pp. 105-110.

McGlynn, AP, Wasson, G, O'Connor, Jacqueline, McKerr, George, McKelvey-Martin, Valerie and Downes, Stephen (1999) The bromodeoxyuridine comet assay: Detection of maturation of recently replicated DNA in individual cells. CANCER RESEARCH, 59 (23). pp. 5912-5916.

Tong, KK, Hannigan, BM, McKerr, George and Strain, JJ (1996) The effects of copper deficiency on human lymphoid and myeloid cells: An in vitro model. British Journal of Nutrition, 75 (1). pp. 97-108.

This list was generated on Fri Oct 31 14:01:50 2014 GMT.