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Professor C. Stephen Downes

Professor of Cancer Biology, Group Leader

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Academic and Professional Qualifications

- 1971: BA Biochemistry, Oxford.
- 1975: D Phil Biochemistry, Oxford.

Career History

- 1995 - present: Professor of Cancer Biology, University of Ulster, Coleraine.
- 1982 - 1995: Senior Research Associate, CRC Mammalian Cell DNA Repair Group, Cambridge.
- 1980 - 1981: Research Associate, CRC Mammalian Cell DNA Repair Group, Cambridge.
- 1975 - 1979: Research Associate, Department of Zoology, Cambridge.
- 1971 - 1974: MRC Research Scholarship, Department of Biochemistry, Oxford.

Teaching & Learning Activities

Human Molecular Genetics.

Brief Biography

Professor Stephen Downes took his primary degree in Biochemistry at Oxford in 1971. He then completed his DPhil degree in Biochemistry at Oxford in 1975. From 1975 to 1995 he built up a substantial research profile at the CRC Mammalian Cell DNA Repair Group, Cambridge, before taking up his current appointment as Professor of Cancer Studies and Head of Cancer and Ageing Research Group at the University of Ulster in Coleraine.

Professor Downes is also the Director of the Biomedical Sciences Research Institute, in which capacity he is responsible for monitoring and evaluating the performance of the ten Biomedical Sciences Research Groups. He meets regularly with the Heads of these groups to discuss strategic requirements and opportunities, and is responsible for the distribution of central resources to these research groups in accordance with their size and performance in relation to a number of indicators. He is also Director of the Centre for Functional Genomics at the University.

In 2004, Professor Downes was awarded the OBE for services to biomedical sciences. Further information is available at the following url: http://www.ulster.ac.uk/news/releases/2004/1480.html

Main Research Interests

Cancer - G2 cell cycle checkpoints / replication / decatenation; cellular responses to DNA damage and repair (especially postreplication and excision repair); DNA methylation; gene/nutrient interactions; novel applications of microarrays; population genetics.

Professor C. Stephen Downes

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Professor C. Stephen Downes - Publications

Number of items: 57.

McAllister, Katherine A., Yasseen, Akeel A., McKerr, George, Downes, Stephen and McKelvey-Martin, Valerie J. (2014) FISH comets show that the salvage enzyme TK1 contributes to gene-specific DNA repair. Frontiers in Genetics, 5.

Barnes, Clifford, McKerr, George, Soto, A. M., Downes, Stephen and Howard, Vyvyan (2014) From Single Cells to Tissues: Interactions between the Matrix and Human Breast Cells in Real Time. PLOS ONE, 9 (4). pp. 1-12.

McGlynn, Angela P, Wasson, Gillian R, O'Reilly, Sharleen R, McNulty, Helene, Downes, C. Stephen, Chang, Chin-Kuo, Hoey, Leane, Molloy, Anne M, Ward, Mary, Strain, JJ, McKerr, George, Weir, Donald G and Scott, John M (2013) Low Colonocyte Folate Is Associated with Uracil Misincorporation and Global DNA Hypomethylation in Human Colorectum. Journal of Nutrition, 143.

Volkert, Michael R., Mórocz, Mónika, Gali, Himabindu, Raskó, István, Downes, Stephen and Haracska, Lajos (2013) Single Cell Analysis of Human RAD18-Dependent DNA Post-Replication Repair by Alkaline Bromodeoxyuridine Comet Assay. PLoS ONE, 8 (8). pp. e70391.

Moore, Johnny, Atkinson, Sarah, Azar, Dimitri T, Worthington, Jenny, Downes, Stephen, Courtney, David G and Moore, Tara (2013) Protection of corneal epithelial stem cells prevents UV-A damage during corneal collagen cross-linking treatment for keratoconus. Br J Ophthalmol , 16.

McKenna, Declan J, Doherty, Bernadette, Downes, Stephen, McKeown, SR and McKelvey-Martin, Valerie J (2012) Use of the Comet-FISH Assay to Compare DNA Damage and Repair in p53 and hTERT Genes following Ionizing Radiation. PLoS ONE, 7 (11). pp. e49364.

Nagy, Dóra, Tömöry, Gyöngyvér, Csányi, Bernadett, Bogácsi-Szabó, Erika, Czibula, Ágnes, Priskin, Katalin, Bede, Olga, Bartosiewicz, László, Downes, Stephen and Raskó, István (2011) Comparison of lactase persistence polymorphism in ancient and present-day Hungarian populations. American Journal of Physical Anthropology, 145 (2). pp. 262.

Sunnotel, Olaf, Walsh, Colum, Downes, Stephen, Hiripi, Laszlo, Robson, Tracy and Hirst, David (2010) Use of FKBPL gene to identify a cause of infertility.University of Ulster (2010) Use of FKBPL gene to identify a cause of infertility.

Sunnotel, Olaf, Walsh, Colum, Downes, Stephen and Lagan, Kevin (2010) Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study.. Reproductive Bioliogy and Endocrinology, 8 (22).

McDaid, J. R., Loughery, J., Dunne, P., Boyer, J. C., Downes, Stephen, Farber, R. A. and Walsh, Colum (2010) MLH1 mediates PARP-dependent cell death in response to the methylating agent N-methyl-N-nitrosourea (vol 101, pg 441, 2009). BRITISH JOURNAL OF CANCER, 102 (6). pp. 1080.

Priskin, K, Szabó, K, Tömöry, G, Bogácsi-Szabó, E, Csányi, B, Eördögh, R, Downes, Stephen and Raskó, I (2010) Mitochondrial sequence variation in ancient horses from the Carpathian Basin and possible modern relatives. Genetica, 138. pp. 211-218.

McArt, DG, McKerr, George, Saetzler, Kurt, Howard, Vyvyan, Downes, Stephen and Wasson, GR (2010) Comet sensitivity in assessing DNA damage and repair in different cell cycle stages. Mutagenesis, 25 (3). pp. 299.

McDaid, J. R., Loughery, J., Dunne, P., Boyer, J. C., Downes, Stephen, Farber, R. A. and Walsh, Colum (2009) MLH1 mediates PARP-dependent cell death in response to the methylating agent N-methyl-N-nitrosourea. BRITISH JOURNAL OF CANCER, 101 (3). pp. 441-451.

Csanyi, B., Bogacsi-Szabo, E., Tomory, Gy., Czibula, A., Priskin, K., Csosz, A., Mende, B., Lango, P., Csete, K., Zsolnai, A., Conant, E. K., Downes, Stephen and Rasko, I. (2008) Y-chromosome analysis of ancient Hungarian and two modern Hungarian-speaking populations from the Carpathian Basin. ANNALS OF HUMAN GENETICS, 72 (Part 4). pp. 519-534.

Wasson, Gillian R, McKelvey-Martin, Valerie and Downes, Stephen (2008) The use of the comet assay in the study of human nutrition and cancer. MUTAGENESIS, 23 (3). pp. 153-162.

Graham, JE, Graham, RLJ, Beirne, Raymond, McGilligan, Victoria, Downes, Stephen, Moore, Johnny, Moore, Tara and McMullan, Geoffrey (2008) The Use of Conjunctival Swab for the Proteomic Characterisation of Dry Eye Syndrome. Journal of Proteomics and Bioinformatics, 1. pp. 20-33.

Fuss, Hendrik, Dubitzky, Werner, Downes, Stephen and Kurth, Mary Jo (2008) Src family kinases and receptors: Analysis of three activation mechanisms by dynamic systems modeling. BIOPHYSICAL JOURNAL, 94 (6). pp. 1995-2006.

Graham, Joanna E., Moore, Johnny, Jiru, Xu, Moore, John E., Goodall, Edward A., Dooley, James S. G., Hayes, Velma, Dartt, Darlene A., Downes, Stephen and Moore, Tara (2007) Ocular pathogen or commensal: A PCR-based study of surface bacterial flora in normal and dry eyes. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 48 (12). pp. 5616-5623.

Sanderson, Peter, Stone, Elaine, Kim, Young-In, Mathers, John C., Kampman, Ellen, Downes, Stephen, Muir, Kenneth R. and Baron, John A. (2007) Folate and colo-rectal cancer risk. BRITISH JOURNAL OF NUTRITION, 98 (6). pp. 1299-1304.

Fuss, Hendrik, Dubitzky, Werner, Downes, Stephen and Kurth, Mary Jo (2007) Deactivation of src family kinases: Hypothesis testing using a Monte Carlo sensitivity analysis of systems-level properties. JOURNAL OF COMPUTATIONAL BIOLOGY, 14 (9). pp. 1185-1200.

Tomory, Gyoengyver, Csanyi, Bernadett, Bogacsi-Szabo, Erika, Kalmar, Tibor, Czibula, Agnes, Csosz, Aranka, Priskin, Katalin, Mende, Balazs, Lango, Peter, Downes, Stephen and Rasko, Istvan (2007) Comparison of maternal lineage and biogeographic analyses of ancient and modern Hungarian populations. AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 134 (3). pp. 354-368.

Moore, Johnny, Graham, JE, Goodall, E, Darrtt, D, Leccisotti, A, Downes, Stephen and Moore, Tara (2007) Correlation between diagnostic tests guides the development and use of a dry eye diagnostic algorithm. In: 5th International Conference, tear film & ocular surface: basic science and clinical relevance, Sciliy. Acta Ophthalmologica Scandinavica. Vol 85 (Suppl 240)

McGilligan, Victoria, Graham, JE, Moore, Johnny, McMullan, Geoffrey, Graham, RLJ, Beirne, Raymond, Downes, Stephen and Moore, Tara (2007) Proteomic analysis of conjucntival swab by mass spectrometry. . In: EVER, Slovenia. Acta Ophthalmologica Scandinavica. Vol 85 (Suppl 240)

Graham, JE, Moore, Johnny, Jiru, X, Goodall, E, Dooley, James, Dartt, D, Downes, Stephen and Moore, Tara (2007) Pathogen or commensal: a pcr based study of ocular surface bacterial flora in normal and dry eyes. . In: ) 5th International Conference, tear film & ocular surface: basic science and clinical relevance, TFOS, Sicily. Acta Ophthalmologica Scandinavica. Vol 85 (Suppl 240 )

McGilligan, Victoria, graham, JE, Moore, Johnny, McMullan, Geoffrey, Graham, RLJ, Beirne, Raymond, Downes, Stephen and Moore, Tara (2007) Proteomic analysis of conjucntival swab by mass spectrometry. In: International Tear Film and Ocular Surface Conference , Sciliy. International Conference, tear film & ocular surface: basic science and clinical relevance. Vol 85 (Suppl 240)

Gilbert, David, Fuss, Hendrik, Gu, Xu, Orton, Richard, Robinson, Steve, Vyshemirsky, Vladislav, Kurth, Mary Jo, Downes, Stephen and Dubitzky, Werner (2006) Computational methodologies for modelling, analysis and simulation of signalling networks. BRIEFINGS IN BIOINFORMATICS, 7 (4). pp. 339-353.

Wasson, Gillian R, McGlynn, Angela P, McNulty, Helene, O'Reilly, Sharleen L, McKelvey-Martin, Valerie, McKerr, George, Strain, JJ, Scott, John and Downes, Stephen (2006) Global DNA and p53 region-specific hypomethylation in human colonic cells is induced by folate depletion and reversed by folate supplementation. JOURNAL OF NUTRITION, 136 (11). pp. 2748-2753.

Graham, JE, Moore, Johnny, Dartt, DA, Best, R, Alarbi, M, McGimpsey, S, Diebold, Y, Downes, Stephen and Moore, Tara (2006) Staphylococcus epidermidis: Friend or Foe in Dry Eye, its Interaction with Conjunctival Goblet Cells. In: European Association for Vision and Eye Research (EVER) International Conference, Portugal. Acta Ophthalmologica Scandinavica . Vol 84 (Suppl 239)

Graham, JE, Moore, Johnny, Dartt, DA, Best, R, Alarbi, M, McGimpsey, S, Diebold, Y, Downes, Stephen and Moore, Tara (2006) Ocular Surface Bacterial Flora - A Conundrum. In: European Association for Vision and Eye Research (EVER) International Conference, Portugal. Acta Ophthalmologica Scandinavica . Vol 84 (Suppl 239)

Fuss, Hendrik, Dubitzky, Werner, Downes, Stephen and Kurth, Mary Jo (2006) Bistable switching and excitable behaviour in the activation of Src at mitosis. BIOINFORMATICS, 22 (14). pp. E158-E165.

Bogacsi-Szabo, E, Kalmar, T, Csanyi, B, Tomory, G, Czibula, A, Priskin, K, Horvath, F, Downes, Stephen and Rasko, I (2005) Mitochondrial DNA of ancient Cumanians: Culturally Asian steppe nomadic immigrants with substantially more western Eurasian mitochondrial DNA lineages. HUMAN BIOLOGY, 77 (5). pp. 639-662.

Fuss, H, Dubitzky, Werner, Downes, Stephen and Kurth, MJ (2005) Mathematical models of cell cycle regulation. BRIEFINGS IN BIOINFORMATICS, 6 (2). pp. 163-177.

Berrar, D, Sturgeon, B, Bradbury, I, Downes, Stephen and Dubitzky, Werner (2005) Survival trees for analyzing clinical outcome in lung adenocarcinomas based on gene expression profiles: Identification of neogenin and diacylglycerol kinase alpha expression as critical factors. JOURNAL OF COMPUTATIONAL BIOLOGY, 12 (5). pp. 534-544.

Berrar, Daniel, Sturgeon, B, Bradbury, I, Downes, Stephen and Dubitzky, Werner (2005) Integration of microarray data for a comparative study of classifiers and identification of marker genes. In: METHODS OF MICROARRAY DATA ANALYSIS IV, Durham, NC. . 147-162

Moore, Johnny, Small, DM, Graham, JE, Atkinson, Sarah, Meenan, BJ, Lui, C, Downes, Stephen and Moore, Tara (2004) The effect of atmospheric plasma surface treatment of poly(methyl methacrylate) PMMA on corneal epithelial cell growth and protein absorption . In: UK Society for Biomaterials, University of Brighton. Ophthalmic Research. Vol 36 (S1), 1467-1467

Moore, Johnny, Small, DM, Graham, JE, Atkinson, Sarah, Meenan, BJ, Lui, C, Downes, Stephen and Moore, Tara (2004) The effect of atmospheric plasma surface treatment of poly (methyl methacrylate) PMMA on corneal epithelial cell growth, protein absorption and cytokine expression. In: European Association for Vision & Eye Research, Vilamoura, Portugal. Journal for Research in Experimental and Clinical Ophthalmology. Vol 36 (S1), 1467-1467

Doherty, SC, McKeown, Stephanie, McKelvey-Martin, Valerie, Downes, Stephen, Atala, A, Yoo, JJ, Simpson, DA and Kaufmann, WK (2003) Cell cycle checkpoint function in bladder cancer. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 95 (24). pp. 1859-1868.

McKenna, DJ, Gallus, M, McKeown, Stephanie, Downes, Stephen and McKelvey-Martin, Valerie (2003) Modification of the alkaline Comet assay to allow simultaneous evaluation of mitomycin C-induced DNA cross-link damage and repair of specific DNA sequences in RT4 cells. DNA REPAIR, 2 (8). pp. 879-890.

Bonham, Maxine P, O'Connor, JM, Alexander, HD, Coulter, J, Walsh, PM, McAnena, LB, Downes, Stephen, Hannigan, BM and Strain, JJ (2003) Zinc supplementation has no effect on circulating levels of peripheral blood leucocytes and lymphocyte subsets in healthy adult men. BRITISH JOURNAL OF NUTRITION, 89 (5). pp. 695-703.

Bonham, M, O'Connor, JM, Alexander, HD, Coulter, J, Walsh, PM, McAnena, LB, Downes, Stephen, Hannigan, BM and Strain, JJ (2003) Zinc supplementation has no effect on circulating levels of peripheral blood leucocytes and lymphocyte subsets in healthy adult men. BRITISH JOURNAL OF NUTRITION, 89 (5). pp. 695-703.

Morocz, M, Csiszar, A, Johnson, RT, Downes, Stephen, Cserpan, I and Rasko, I (2003) Variation in sequence-specific repair of UV damage in human pericentromeric heterochromatin of different cell lines. CANCER LETTERS, 193 (2). pp. 189-197.

McGlynn, AP, Wasson, GR, O'Reilly, S, McKelvey-Martin, Valerie, McNulty, Helene, Strain, JJ, McKerr, George, Mullan, F, Mahmud, N, Scott, J, Weir, DG and Downes, Stephen (2003) Detection of replicative integrity in small colonic biopsies using the BrdUrd comet assay. BRITISH JOURNAL OF CANCER, 88 (6). pp. 895-901.

Bonham, M, O'Connor, JM, McAnena, Liadhan, Walsh, PM, Downes, Stephen, Hannigan, BM and Strain, JJ (2003) Zinc supplementation has no effect on lipoprotein metabolism, hemostasis, and putative indices of copper status in healthy men. BIOLOGICAL TRACE ELEMENT RESEARCH, 93 (1-3). pp. 75-86.

Bonham, Maxine P, O'Connor, Jacqueline, McAnena, Liadhan, Walsh, PM, Downes, Stephen, Hannigan, BM and Strain, JJ (2003) Zinc supplementation has no effect on lipoprotein metabolism, hemostasis, and putative indices of copper status in healthy men. Biological Trace Element Research, 93 (1-3). pp. 75-86.

Deming, PB, Flores, KG, Downes, Stephen, Paules, RS and Kaufmann, WK (2002) ATR enforces the topoisomerase II-dependent G(2) checkpoint through inhibition of Plk1 kinase. JOURNAL OF BIOLOGICAL CHEMISTRY, 277 (39). pp. 36832-36838.

Kaufmann, WK, Campbell, CB, Simpson, DA, Deming, PB, Filatov, L, Galloway, DA, Zhao, XJ, Creighton, AM and Downes, Stephen (2002) Degradation of ATM-independent checkpoint function in human cells is secondary to inactivation of p53 and correlated with chromosome destabilization. Cell Cycle, 1 (3). pp. 210-219.

Morocz, M, Kalman, J, Juhasz, A, Sinko, I, McGlynn, AP, Downes, Stephen, Janka, Z and Rasko, I (2002) Elevated levels of oxidative DNA damage in lymphocytes from patients with Alzheimer's disease. NEUROBIOLOGY OF AGING, 23 (1). pp. 47-53.

Deming, PB, Cistulli, CA, Zhao, H, Graves, PR, Piwnica-Worms, H, Paules, RS, Downes, Stephen and Kaufmann, WK (2001) The human decatenation checkpoint. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98 (21). pp. 12044-12049.

Miyaji, EN, Johnson, RT, Downes, Stephen, Eveno, E, Mezzina, M, Sarasin, A and Menck, CFM (2000) Characterization of a mutant rat kangaroo cell line with alterations in the cell cycle and DNA repair. GENETICS AND MOLECULAR BIOLOGY, 23 (3). pp. 689-694.

Downes, Stephen, Bachrati, CZ, Devlin, SJ, Tommasino, M, Cutts, TJR, Watson, JV, Rasko, I and Johnson, RT (2000) Mammalian S-phase checkpoint integrity is dependent on transformation status and purine deoxyribonucleosides. JOURNAL OF CELL SCIENCE, 113 (6). pp. 1089-1096.

McGlynn, AP, Wasson, G, O'Connor, Jacqueline, McKerr, George, McKelvey-Martin, Valerie and Downes, Stephen (1999) The bromodeoxyuridine comet assay: Detection of maturation of recently replicated DNA in individual cells. CANCER RESEARCH, 59 (23). pp. 5912-5916.

Joyce, KM, Downes, Stephen and Hannigan, BM (1999) Radioadaptation in Indian muntjac fibroblast cells induced by low intensity laser irradiation. MUTATION RESEARCH-DNA REPAIR, 435 (1). pp. 35-42.

Joyce, KM, Downes, Stephen and Hannigan, BM (1999) Cell-cycle delay is induced in cells of a U937 promonocytic cell line by low-intensity light irradiation at 660 nm. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 52 (1-3). pp. 117-122.

Bachrati, CZ, Downes, Stephen and Rasko, I (1999) Chemical reverse transformation of CHO-K1 cells induces changes in expression of a candidate tumour suppressor and of a gene not previously characterised as transformation related. EUROPEAN JOURNAL OF CELL BIOLOGY, 78 (8). pp. 561-566.

Gimenez-Abian, JF, Clarke, DJ, de la Torre, C, Gimenez-Martin, G, Mullinger , AM, Downes, Stephen and Johnson, RT (1999) Competence for assembly of sister chromatid cores is progressively acquired during S phase in mammalian cells. EUROPEAN JOURNAL OF CELL BIOLOGY, 78 (8). pp. 601-603.

Clarke, DJ, Gimenez-Abian, JF, Tonnies, H, Neitzel, E, Sperling, K, Downes, Stephen and Johnson, RT (1998) Creation of monosomic derivatives of human cultured cell lines. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 95 (1). pp. 167-171.

McKelvey-Martin, Valerie, Ho, ETS, McKeown, Stephanie, Johnston, SR, McCarthy, PJ, Rajab, NF and Downes, Stephen (1998) Emerging applications of the single cell gel electrophoresis (Comet) assay. I. Management of invasive transitional cell human bladder carcinoma. II. Fluorescent in situ hybridization Comets for the identification of damaged and repaired DNA sequences in individual cells. MUTAGENESIS, 13 (1). pp. 1-8.

This list was generated on Thu Oct 23 04:01:04 2014 BST.