Introduction
The Group’s work focuses on classical and non-classical mechanisms of transcriptional control.
The group has an established profile in examining epigenetic changes in cell differentiation and de-differentiation.
There is also a strong interest in steroid hormone receptors, particularly Vitamin D and Androgen receptor, their target genes and modulation of their activities by coactivators and corepressors which modify chromatin structure or cause changes in DNA methylation.
We are also interested in prostate cancer, and the changes in gene activity and epigenetic marks which take place during tumorigenesis, particularly in the anoxic cell.
The non-canonical quadruplex DNA structure and its role in transcriptional control is also an active area of research.
