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Transcriptional Regulation and Epigenetics
Dr Mateus Webba da Silva
Lecturer in Pharmaceutical Chemistry
- Dr Mateus Webba da Silva
Academic and Professional Qualifications:
Career Summary:
Sr Research Associate: Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA (2001-2005)
Research Associate: Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA (1999-2001)
Postdoctoral Associate, Department of Chemistry, University of California, Davis, USA (1997-1999).
PhD in Chemistry, University of Exeter (UK)
Selected publications
Webba da Silva M. "NMR Methods for Studying Quadruplex Nucleic Acids"; Methods 43 (2007) 264-277.
J.-L. Mergny, A. De Cian, S. Amrane, M. Webba da Silva; “Kinetics of Double-Chain Reversals Bridging Contiguous Quartets in Tetramolecular Quadruplexes†; Nucl. Acids Res., 34 (2006) 2386-2397.
M. Webba da Silva. “Experimental Demonstration of T:(G:G:G):T Hexad and T:A:A:T Tetrad Alignments within a DNA Quadruplex Stem†, Biochemistry, 44 (2005) 3754-3764.
M. Webba da Silva. “Experimental Demonstration of T:(G:G:G):T Hexad and T:A:A:T Tetrad Alignments within a DNA Quadruplex Stem†, Biochemistry, 44 (2005) 3754-3764.
M. Webba da Silva. “Association of DNA Quadruplexes Through G:C:G:C Tetrads. Solution Structure of d(GCGGTGGAT)†, Biochemistry, 42 (2003) 14356-14365.
M. Webba da Silva, S. Sham, C. M. Gorst, L. Calzolai, P. S. Brereton, M. W. W. Adams and G. N. La Mar. “Solution NMR Characterization of the Thermodynamics of the Disulfide Bond Orientational Isomerism and Its Effect on Cluster Properties for the Hyperthermostable Three-Iron Cluster Ferredoxin from the Archaeon Pyrococcus Furiosus†, Biochemistry, 40 (2001) 12575-12583.
K. G. Orrell, A. G. Osborne, V. Sik, M. Webba da Silva, and N. Vassilev. “Stereochemically Non-Rigid Transition Metal Complexes of 2,6-bis[(1-phenylimino)-ethyl]pyridine (BIP). Part 3. Dynamic NMR Studies of [PtXMe3(BIP)] (X = Cl, Br, and I), and Crystal Structure of [PtIMe3(BIP)]†, J. Organomet. Chem., 555 (1998) 35-47.
K. G. Orrell, A. G. Osborne, V. Sik, M. Webba da Silva, M.B. Hursthouse, D.E. Hibbs, K.M. Abdul Malik, N.G. Vassilev. “Stereochemically Non-Rigid Transition Metal Complexes of 2,6-bis[(1-phenylimino)-ethyl]pyridine (BIP). Part 2. Dynamic NMR Studies of fac[ReX(CO)3(BIP)] (X = Cl, Br, or I). Crystal Structure of fac[ReI(CO)3(BIP)]†, J. Organomet. Chem., 538 (1997) 171-183.
K. G. Orrell, A. G. Osborne, V. Sik, M. Webba da Silva. “Stereochemically Non-Rigid Transition Metal Complexes of 2,6-bis[(1-phenylimino)-ethyl]pyridine (BIP). Part 1. Dynamic NMR Studies of [M(C6H6)2(BIP)] [M = Pd(II) or Pt(II)]†, J. Organomet. Chem., 530 (1997) 235-246.
A. G. Osborne, M. Webba da Silva, M.B. Hursthouse, K.M.A. Malik, G. Opromolla and P. Zanello. “Synthetic Structural and Electrochemical Studies on some Ferrocenylazines. Crystal Structures of [4](1)(1,4-dimethyl-2,3-diazabuta-1,3-dien)ferroce-nophane and [42](1,1’)bis(1,4-dimethyl-2,3-diazabuta-1,3-dien)ferrocenophane†, J. Organomet. Chem., 516 (1996) 167.
Research Themes
Structure of Nucleic Acid Quadruplexes