Transcriptional Regulation and Epigenetics

Karsisiotis, Ioannis, Ma’ani Hessari, N, Novellino, E, Spada, GP, Randazzo, A and Webba da Silva, Mateus (2011) Topological Characterization of G-Quadruplexes by UV Absorption and Circular Dichroism. Angewandte Chemie International Edition, 50. pp. 10645-10648.

Chang, Chin-Kuo, Mulholland, HG, Cantwell, MM, Anderson, LA, Johnston, BT, McKnight, AJ, Thompson, Paul, Watson, RM and Murray, LJ (2011) Vitamin D Receptor Gene Variants and Esophageal Adenocarcinoma Risk: A Population-Based Case-Control Study. Journal of Gastrointestinal Cancer , Epub ahead of print. PMID:21948293.

Sunnotel, Olaf, Walsh, Colum, Downes, Stephen, Hiripi, Laszlo, Robson, Tracy and Hirst, David (2010) Use of FKBPL gene to identify a cause of infertility.University of Ulster (2010) Use of FKBPL gene to identify a cause of infertility.

Haussler, MR, Haussler, CA, Whitfield, GK, Hsieh, JC, Thompson, Paul, Barthel, TK, Bartik, L, Egan, JB, Wu, J, Kubicek, JL, Lowmiller, CL, Moffet, EW, Forster, RE and Jurutka, PW (2010) The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the "Fountain of Youth" to mediate healthful aging. J Steroid Biochem Mol Biol, 121 (1-2). pp. 88-97.

Eritja, R, Mergny, J.L., Montesarchio, D, Spindler, L and Webba da Silva, Mateus (2010) G-Quadruplex Nucleic Acids. Journal of Nucleic Acids, 2010 (Article ID 147650).

Groves, P and Webba da Silva, Mateus (2010) Rapid Stoichiometric Analysis of G-Quadruplexes in Solution. Chem. Eur. J., 16. pp. 6451-6453.

Spindler, L, Rigler, R, Drevenˇsek-Olenik, I, Ma’ani Hessari, N and Webba da Silva, Mateus (2010) Effect of Base Sequence on G-Wire Formation in Solution. Journal of Nucleic Acids, 2010 (Article ID 431651,).

Sunnotel, Olaf, Walsh, Colum, Downes, Stephen and Lagan, Kevin (2010) Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study.. Reproductive Bioliogy and Endocrinology, 8 (22).

Devlin, Andrea, Thompson, Paul, Robson, Tracy and McKeown, SR (2010) Cytochrome P450 1B1 mRNA Untranslated Regions Interact to Inhibit Protein Translation. Molecular Carcinogenesis, 49 (2). pp. 190-199.

Watson, Jenny A, McKenna, Declan J, Maxwell, Perry, Diamond, James, Arthur, Ken, McKelvey-Martin, Valerie J and Hamilton, Peter W (2010) Hyperacetylation in prostate cancer induces cell cycle aberrations, chromatin reorganization and altered gene expression profiles. Journal of Cellular and Molecular Medicine, 14 (6b). pp. 1668-1682 .

Martin, P, Riley, R, Thompson, Paul, Williams, D, Back, D and Owen, A (2010) Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells. Acta Pharmacol Sin, 31 (1). pp. 51-65.

McKenna, DJ, McDade, SS, Patel, D and McCance, DJ (2010) MicroRNA 203 Expression in Keratinocytes Is Dependent on Regulation of p53 Levels by E6. Journal of Virology, 84 (20). pp. 10644.

Adams, Catherine, McCarthy, Helen O., Coulter, Jonathan A., Worthington, Jenny, Murphy, Claire, Robson, Tracy and Hirst, Davi G. (2009) Nitric oxide synthase gene therapy enhances the toxicity of cisplatin in cancer cells. JOURNAL OF GENE MEDICINE, 11 (2). pp. 160-168.

Webba da Silva, Mateus, Trajkovski, Marko, Sannohe, Yuta, Hessari, Nason, Sugiyama, Hiroshi and Plavec, Janez (2009) Design of a G-Quadruplex Topology through Glycosidic Bond Angles. Angewandte Chemie International Edition, 48.

Wilson, C, Scullin, P, Worthington, Jenny, Seaton, A, Maxwell, P, O'Rourke, D, Johnston, PG, McKeown, Stephanie, Wilson, RH, O'Sullivan, JM and Waugh, DJJ (2008) Dexamethasone potentiates the antiangiogenic activity of docetaxel in castration-resistant prostate cancer. BRITISH JOURNAL OF CANCER, 99 (12). pp. 2054-2064.

Marignol, L., Robson, T., McCarthy, H. O., Worthington, Jenny, Murray, M. M., Hollywood, D., Lawler, M. and Hirst, D. G. (2008) The tissue plasminogen activator gene promoter: a novel tool for radiogenic gene therapy of the prostate?. JOURNAL OF GENE MEDICINE, 10 (9). pp. 1032-1038.

Butterworth, Karl T, McCarthy, Helen O, Devlin, Andrea, Ming, Louise, Robson, Tracy, McKeown, Stephanie and Worthington, Jenny (2008) Hypoxia selects for androgen independent LNCaP cells with a more malignant geno- and phenotype. INTERNATIONAL JOURNAL OF CANCER, 123 (4). pp. 760-768.

Coulter, J. A., McCarthy, H. O., Worthington, Jenny, Robson, T., Scott, S. and Hirst, D. G. (2008) The radiation-inducible pE9 promoter driving inducible nitric oxide synthase radiosensitizes hypoxic tumour cells to radiation. GENE THERAPY, 15 (7). pp. 495-503.

O'Rourke, Martin, Ward, Claire, Worthington, Jenny, McKenna, Julie, Valentine, Andrea, Robson, Tracy, Hirst, David G and McKeown, Stephanie (2008) Evaluation of the antiangiogenic potential of AQ4N. CLINICAL CANCER RESEARCH, 14 (5). pp. 1502-1509.

Webba da Silva, Mateus (2007) Geometric Formalism for DNA Quadruplex F olding. Chem. Eur. J., 13.

McCarthy, Helen O., Coulter, Jonathan A., Worthington, Jenny, Robson, Tracy and Hirst, David G. (2007) Human osteocalcin: a strong promoter for nitric oxide synthase gene therapy, with specificity for hormone refractory prostate cancer. JOURNAL OF GENE MEDICINE, 9 (6). pp. 511-520.

Webba da Silva, Mateus (2007) NMR methods for studying quadruplex nucleic acids. Methods, 43.

McCarthy, HO, Worthington, Jenny, Barrett, E, Cosimo, E, Boyd, M, Mairs, RJ, Ward, C, McKeown, Stephanie, Hirst, DG and Robson, T (2007) p(21(WAF1))-mediated transcriptional targeting of inducible nitric oxide synthase gene therapy sensitizes tumours to fractionated radiotherapy. GENE THERAPY, 14 (3). pp. 246-255.

Green, CD, Thompson, Paul, Johnston, PG and El-Tanani, MK (2007) Interaction between transcription factor, basal transcription factor 3, and the NH2-terminal domain of human estrogen receptor alpha. Molecular Cancer Research, 5. pp. 1191-1200.

Mergny, J.L., De Cian, A, Amrane, S and Webba da Silva, Mateus (2006) Kinetics of double-chain reversals bridgingcontiguous quartets in tetramolecular quadruplexes. Nucleic Acids Research, 34.

Worthington, J, Robson, T, Scott, S and Hirst, D (2005) Evaluation of a synthetic CArG promoter for nitric oxide synthase gene therapy of cancer. GENE THERAPY, 12 (19). pp. 1417-1423.

Adams, DJ, Webba da Silva, Mateus, Kohlhagen, G, Pommier, Y, Colvin, OM, Manikumar, G and Wani, MC (2005) Camptothecin analogs with enhanced activity against human breastcancer cells. I. Correlation of potency with lipophilicity and persistence inthe cleavage complex. Cancer Chemother Pharmacol, 57.

Robson, T, Worthington, Jenny, McKeown, Stephanie and Hirst, DG (2005) Radiogenic therapy: Novel approaches for enhancing tumor radiosensitivity. TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 4 (4). pp. 343-361.

Webba da Silva, Mateus, Bierbryer, RG, Wilds, CJ, Noronha, AM, Miller, PS and Gamcsik, MP (2005) Intrastrand base-stacking buttresses widening of major groovein interstrand cross-linked B-DNA. Bioorganic & Medicinal Chemistry, 13.

Jurutka, PW, Thompson, Paul, Whitfield, GK, Eichhorst, KR, Hall, N, Dominguez, CE, Hsieh, JC, Haussler, CA and Haussler, MR (2005) Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4. J Cell Biochem, 94 (5). pp. 917-943.

Noll, DM, Webba da Silva, Mateus, Noronha, AM, Wilds, CJ, Colvin, OM, Gamcsik, MP and Miller, PS (2005) Structure, Flexibility, and Repair of Two Different Orientations of the Same AlkylInterstrand DNA Cross-Link†. Biochemistry, 44.

Webba da Silva, Mateus (2005) Experimental Demonstration of T:(G:G:G:G):T Hexad and T:A:A:T TetradAlignments within a DNA Quadruplex Stem. Biochemistry, 44.

Webba da Silva, Mateus, Wilds, CJ, Noronha, AM, Colvin, OM, Miller, PS and Gamcsik, MP (2004) Accommodation of Mispair Aligned N3T-Ethyl-N3T DNA Interstrand Cross Link. Biochemistry, 43.

Worthington, Jenny, McCarthy, HO, Barrett, E, Adams, C, Robson, T and Hirst, DG (2004) Use of the radiation-inducible WAF1 promoter to drive iNOS gene therapy as a novel anti-cancer treatment. JOURNAL OF GENE MEDICINE, 6 (6). pp. 673-680.

Heavey, Patricia M, McKenna, Declan J and Rowland, Ian R (2004) Colorectal cancer and the relationship between genes and the environment.. Nutrition and cancer, 48 (2). pp. 124-41.

Webba da Silva, Mateus (2003) Association of DNA Quadruplexes through G:C:G:C Tetrads. Solution Structure ofd(GCGGTGGAT). Biochemistry, 42.

Hsieh, JC, Whitfield, GK, Jurutka, PW, Haussler, CA, Thatcher, ML, Thompson, Paul, Dang, HT, Gilligan, MA, Oza, AK and Haussler, MR (2003) Two basic amino acids C-terminal of the proximal box specify functional binding of the vitamin D receptor to its rat osteocalcin deoxyribonucleic acid-responsive element. . Endocrinology, 144. pp. 5065-5080.

Otte, K, Kranz, H, Kober, I, Thompson, Paul, Hoefer, M, Haubold, B, Remmel, B, Voss, H, Kaiser, C, Albers, M, Cheruvallath, Z, Jackson , D, Casari, G, Koegl, M, Paabo , S, Mous, J, Kremoser, C and Deuschle, U (2003) Identification of FXR as a novel mammalian nuclear receptor sensing lanosterol . Biochemical and Biophysical Research Communications, 23 (3). pp. 864-872.

Webba da Silva, Mateus, Noronha, AM, Noll, DM, Miller, PS, Colvin, OM and Gamcsik, MP (2002) Solution Structure of a DNA Duplex Containing Mispair-AlignedN4C-Ethyl-N4C Interstrand Cross-Linked Cytosines†. Biochemistry, 41.

Worthington, Jenny, Robson, T, O'Keeffe, M and Hirst, DG (2002) Tumour cell radiosensitization using constitutive (CMV) and radiation inducible (WAF1) promoters to drive the iNOS gene: a novel suicide gene therapy. GENE THERAPY, 9 (4). pp. 263-269.

Thompson, Paul, Jurutka, PW, Whitfield, G, Myskowski, SM, Eichhorst, KR, Encinas Dominguez , C, Haussler, CA and Haussler, MR (2002) Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements . Biochemical and Biophysical Research Communications, 20 (299). pp. 730-738.

Webba da Silva, Mateus, Sham, S, Gorst, CM, Calzolai, L, Brereton, PS, Adams, MWW and La Mar, GN (2001) Solution NMR Characterization of the Thermodynamics of the Disulfide BondOrientational Isomerism and Its Effect of Cluster Electronic Properties for theHyperthermostable Three-Iron Cluster Ferredoxin from the Archaeon Pyrococcusfuriosus. Biochemistry, 40.

McKenna, Declan J, Nelson, J and Stitt, Alan (2001) Advanced glycation alters expression of the 67kDa laminin receptor in retinal microvascular endothelial cells. Life Sciences, 68 (24). pp. 2695.

McKenna, Declan J (2001) Expression of the 67kDa Laminin Receptor (67LR) during Retinal Development: Correlations with Angiogenesis. Experimental Eye Research, 73 (1). pp. 81.

Jurutka, PW, MacDonald, PN, Nakajima, S, Hsieh, JC, Thompson, Paul, Whitfield, GK, Galligan, MA, Haussler, CA and Haussler, MR (2001) Isolation of baculovirus-expressed human vitamin D receptor: DNA responsive element interactions and phosphorylation of the purified receptor. J. Cell Biochem, 85. pp. 435-57.

Thompson, Paul, Remus, LS, Hsieh, JC, Jurutka, PW, Whitfield, GK, Galligan, MA, Encinas Dominguez, C, Haussler, CA and Haussler, MR (2001) Distinct Activation Function-2 (AF-2) Residues in RXR Determine Transactivation in the Context of VDR-RXR Heterodimers versus RXR-RXR Homodimers. Journal of Molecular Endocrinology, 27. pp. 211-227.

Worthington, Jenny, Robson, T, Murray, M, O'Rourke, M, Keilty, G and Hirst, DG (2000) Modification of vascular tone using iNOS under the control of a radiation-inducible promoter. GENE THERAPY, 7 (13). pp. 1126-1131.

Jurutka, PW, Remus , LS, Whitfield, GK, Thompson, Paul, Hsieh, JC, Zitzer, H, Tavokkoli, P, Galligan, MA, Dang, HT, Haussler, CA and Haussler, MR (2000) The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. Mol Endocrinology, 14. pp. 401-420.

Thompson, Paul, Hsieh, JC, Haussler, CA, Whitfield, GK, JB , Tillman, Spindler, SR and Haussler, MR (1999) VDR Binds DNA and Transactivates as a Dimeric Complex with RXR, but not with Thyroid Hormone Receptor (TR). J. Cell. Biochem, 75. pp. 462-480.

Hsieh, JC, Whitfield, GK, Oza, AK, Dang, HT, Price, JN, Galligan, MA, Jurutka, PW, Thompson, Paul, Haussler, CA and Haussler, MR (1999) Characterization of unique DNA-binding and transcriptional-activation functions in the carboxyl-terminal extension of the zinc finger region in the human vitamin D receptor. Biochemistry, 38. pp. 16347-16358.

Stitt, A W, McKenna, Declan, Simpson, D A, Gardiner, T A, Harriott, P, Archer, D B and Nelson, J (1998) The 67-kd laminin receptor is preferentially expressed by proliferating retinal vessels in a murine model of ischemic retinopathy.. The American journal of pathology, 152 (5). pp. 1359-65.

Maliarik, M, Glaser, J, Toth, Imre, Webba da Silva, Mateus and Zekany, L (1998) A New Class of Oligonuclear Platinum-Thallium Compounds with a DirectMetal2Metal Bond3. Unusual Equilibria in Aqueous Solution. Eur. J. Inorg. Chem., 1998. pp. 565-570.

Orrell, KG, Osborne, AG, Sik, V, Webba da Silva, Mateus, Hursthouse, MB, Hibbs, DE, Abdul Malik, KM and Vassilev, NG (1998) Stereochemically non-rigid transition metal complexes of2,6-bis[1-(phenylimino)ethyl]pyridine (BIP). Part 3. Dynamic NMRstudies of fac-[PtXMe3(BIP)] (X C1, Br, or I). Crystal structure offac-[PtIMe3(BIP)]. Journal of Organometallic Chemistry, 555. pp. 35-47.

Thompson, Paul, Jurutka, PW, Haussler, CA, Whitfield , GK and Haussler, MR (1998) R Heterodimeric DNA binding by the vitamin D receptor and retinoid X receptors is enhanced by 1,25-dihydroxyvitamin D3 and inhibited by 9-cis retinoic acid: Evidence for allosteric receptor interactions. Journal of Biological Chemistry, 273. pp. 8483-8491.

Orrell, KG, Osborne, AG, Sik, V, Webba da Silva, Mateus, Hursthouse, MB, Hibbs, DE, Abdul Malik, KM and Vassilev, NG (1997) Stereochemically non-rigid transition metal complexes of2,6-bis[(1-phenylimino)ethyl]pyridine (BIP)Part 2. Dynamic NMR studies of fac-[ReX(CO)3(BIP)](X = C1, Br, or I).Crystal structure of fac-[ReBr(CO)3(BIP)]. Journal of Organometallic Chemistry, 538. pp. 171-183.

Orrell, KG, Osborne, AG, Sik, V and Webba da Silva, Mateus (1997) Stereochemically non-rigid transition metal complexes of2,6-bis[(1-phenylimino) ethyl]pyridine (BIP)Part 1. Dynamic NMR studies of[M( C6F 5) 2(BIP)] (M = Pd II or Pt II). Journal of Organometallic Chemistry, 530. pp. 235-246.

Orrell, KG, Osborne, AG, Webba da Silva, Mateus, Hursthouseb, MB and Coles, SJ (1997) Preparation and characterisation of rhenium(I)and platinum(IV) complexes of 2,6-bis(pyrazol-lylmethyl)pyridine and 2,6=bis(3,5-dimethylpyrazol-1-ylmethyl)pyridine. Crystalstructure of fac-[ReI(CO),(BMPz)]. Polyhedron, 16. pp. 3003-3017.

Osborne, AG, Webba da Silva, Mateus, Hursthouse, MB, Malik, KMA, Opromolla, G and Zanello, P (1996) Synthetic, structural and electrochemical studieson some ferrocenylazines: crystal structuresof [4]( 1)( 1,4-dimethyl-2,3-diazabuta- 1,3-dien) ferrocenophaneand [42 ](1,1') bis( 1,4-dimethyl-2,3-diazabuta- 1,3-dien) ferrocenophane. Journal of Organometallic Chemistry, 516. pp. 167-176.

Orrell, KG, Osborne, AG, Sik, V and Webba da Silva, Mateus (1995) NMR STUDIES OF FLUXIONAL RHENIUM CARBONYLCOMPLEXES OF 2,6-DIACETYLPYRIDINE (DAP),fac-[ReX ( CO )a(D AP)] . Polyhedron, 14. pp. 2797-2802,.